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The rewiring of synaptic circuitry pertinent to memory formation in the brain has often been associated with morphological changes in dendritic spines and extracellular matrix (ECM) remodeling. Here, we linked these processes by uncovering the signaling pathway involving the serotonin 5-HT7 receptors (5 HT7R) the matrix metalloproteinase-9 (MMP-9), the hyaluronan receptor CD44, and the small GTPase...
Spółki Wodne są organizacjami na których spoczywa utrzymanie i eksploatacje szczegółowych systemów melioracyjnych. Działania te są prowadzone w imieniu i na koszt rolników, właścicieli zazwyczaj drobnej sieci rowów odwadniających. Spółki przeżywają obecnie trudny okres z uwagi na brak środków finansowych, wynikających m.in. z braku zainteresowania rolników prawidłowym utrzymaniem urządzeń wodnych...
Tissue plasminogen activator tPA is used for treatment of ischemic stroke patient. This thrombolytic agent resurrect blood supply to brain tissue, that is sensitive to oxygen and glucose deprivation. Administration of tPA is the only approved treatment and might be conducted up to 3 or 4.5 hours after ischemic stroke symptom onset. The benefits of it are time dependent and there is need for an improvement...
Spółki wodne obejmują swoim działaniem 575 460 ha obszaru, tj. około 74% powierzchni zmeliorowanej województwa mazowieckiego. W artykule przedstawiono sytuację spółek na tle obecnych warunków gospodarczych oraz przepisów zawartych w Prawie wodnym i innych aktach prawnych. Na zakończenie artykułu Autorzy przedstawiają problemy, które powinny być rozwiązane, aby umożliwić spółkom realizacje ich zadań...
CPPG is a highly potent group III metabotropic glutamate receptor (mGluR4/6/7/8) antagonist with selective affi nity to mGluR4. The aim of the present study was to determine the effects of CPPG on spatial memory in the water maze, and on the activity of MMP-2 and MMP9 metalloproteases in the hippocampus of rats without and after hypoxia. Short-term hypoxia (2% O2 and 98% N2) enhances excitatory synaptic...
Elucidation of protease substrates (“proteodegradomes”) is essential for understanding the proteolytic pathways and their networks and thus their role in the regulation of cell function. Matrix metalloproteinase-9 (MMP-9) is expressed by the adult brain and released in response to enhanced neuronal activity. It is well established that MMP-9 is involved in neuronal plasticity, including long-term...
Matrix metalloproteinase-9 (MMP-9) has emerged as a physiological regulator of NMDA receptor (NMDAR)-dependent synaptic plasticity and memory. The pathways by which MMP-9 affects NMDAR signaling remain, however, not well understood. Using single Quantum Dot tracking we demonstrate that MMP-9 enzymatic activity increases NR1-NMDAR surface traffi cking but has no infl uence on AMPA receptor (AMPAR)...
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