Search results for: Amit Chakrabarty

Items from 1 to 11 out of 11 results

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PD45-01 A PROSPECTIVE EVALUATION OF FACTORS AFFECTING SERUM TESTOSTERONE LEVELS AFTER TESTOPEL® THERAPY IN PATIENTS WITH LATE ONSET HYPOGONADISM (LOH): A SINGLE CENTRE EXPERIENCE.

Amit Chakrabarty, Anup Gupta

The Journal of Urology > 2015 > 193 > 4 Supplement > e902

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Anatomy and morphology of giant aneurysms—angiographic study of 125 consecutive cases

Ville Nurminen, Martin Lehecka, Amit Chakrabarty, Riku Kivisaari, more

Acta Neurochirurgica > 2014 > 156 > 1 > 1-10

Background Giant intracranial aneurysms are rare and heterogeneous lesions with complex vascular anatomy. The aim of this retrospective study was to provide a comprehensive description of the anatomical features of giant aneurysms. Methods We identified 125 patients with 129 giant aneurysms (≥25 mm) who were treated between 1987 and 2007 at the Department of Neurosurgery of Helsinki University Central...

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Does pelvic mesh treated with phosphorylcholine improve outcomes? An early experience

Amit Chakrabarty, Kumaresan Ganabathi, J. Steven Alexander, Philip Hoekstra, more

European Journal of Obstetrics and Gynecology > 2013 > 167 > 2 > 230-234

Implantable devices treated with phosphorylcholine (PC) have been successfully used in cardiac, ophthalmic, and other applications. This surface modification has resulted in a reduction in the host inflammatory responses. This pilot study tested the safety and efficacy of PC treated polypropylene mesh grafts implanted for the treatment of pelvic organ prolapse.Surgeons from five U.S. sites collected...

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Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA: Effects of aminophospholipids and cholesterol

Poppy Datta, Sudipa Chakrabarty, Amit Chakrabarty, Abhijit Chakrabarti

BBA - Biomembranes > 2008 > 1778 > 1 > 1-9

The interaction of hemoglobin with phospholipid bilayer vesicles (liposomes) has been analyzed in several studies to better understand membrane–protein interactions. However, not much is known on hemoglobin interactions with the aminophospholipids, predominantly localized in the inner leaflet of erythrocytes, e.g., phosphatidylserine (PS), phosphatidylethanolamine (PE) in membranes containing phosphatidylcholine...

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Spectrin interactions with globin chains in the presence of phosphate metabolites and hydrogen peroxide: implications for thalassaemia

Poppy Datta, Sudipa Chakrabarty, Amit Chakrabarty, Abhijit Chakrabarti

Journal of Biosciences > 2007 > 32 > 2 > 1147-1151

We have shown the differential interactions of the erythroid skeletal protein spectrin with the globin subunits of adult haemoglobin (HbA); these indicate a preference for α-globin over that for β-globin and intact HbA in an adenosine 5′-triphosphate (ATP)-dependent manner. The presence of Mg/ATP led to an appreciable decrease in the binding affinity of the α-globin chain to spectrin and the overall...

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Crystal Structures of HbA ₂ and HbE and Modeling of Hemoglobin δ ₄ : Interpretation of the Thermal Stability and the Antisickling Effect of HbA ₂ and Identification of the Ferrocyanide Binding Site in Hb ^‡

Udayaditya Sen, Jhimli Dasgupta, Debi Choudhury, Poppy Datta, more

Biochemistry > 2004 > 43 > 39 > 12477 - 12488

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Interaction of erythroid spectrin with hemoglobin variants: implications in β-thalassemia

Poppy Datta, Sudipa Basu Chakrabarty, Amit Chakrabarty, Abhijit Chakrabarti

Blood Cells, Molecules and Diseases > 2003 > 30 > 3 > 248-253

Among the few studies, producing contradictory results, done on the interaction of erythroid membrane skeletal spectrin with hemoglobin (Hb), none has been able to provide a quantitative estimate of the association of spectrin with Hb. In this work, studies on the interactions of erythroid spectrin with Hb have been elaborated upon using a novel fluorescence technique. The concentration-dependent...

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Crystallization and preliminary X-ray structural studies of hemoglobin A ₂ and hemoglobin E, isolated from the blood samples of β-thalassemic patients

Jhimli Dasgupta, Udayaditya Sen, Debi Choudhury, Poppy Datta, more

Biochemical and Biophysical Research Communications > 2003 > 303 > 2 > 619-623

Hemoglobin A ₂ (α ₂ δ ₂ ), a minor (2-3%) component of circulating red blood cells, acts as an anti-sickling agent and its elevated concentration in β-thalassemia is a useful clinical diagnostic. In β-thalassemia major, where there is a failure of β-chain production, HbA ₂ acts as the predominant oxygen deliverer. Hemoglobin E, is another common abnormal hemoglobin,...

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Priapism Associated with Sickle Cell Hemoglobinopathy in Children: Long-Term Effects on Potency

Amit Chakrabarty, J. Upadhyay, C.B. Dhabuwala, S. Sarnaik, more

The Journal of Urology > 1996 > 155 > 4 > 1419-1423

Children with sickle cell priapism have traditionally been treated conservatively with surgery done as a last resort. Only sparse subjective data are available on the long-term assessment of potency in these patients. We retrospectively reviewed the charts of all pediatric patients with sickle cell priapism who presented to Children's Hospital of Michigan between 1972 and 1992, and subsequently...

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Interobserver Consistency of Digital Rectal Examination in Clinical Staging of Localized Prostatic Carcinoma

Javier C. Angulo, James E. Montie, Timothy Bukowsky, Amit Chakrabarty, more

Urologic Oncology: Seminars and Original Investigations > 1995 > 1 > 5 > 199-205

A prospective study was undertaken to determine the reproducibility of clinical staging based on digital rectal examination (DRE) in prostate carcinoma. We evaluated 48 consecutive patients diagnosed with localized prostatic cancer. Four urologists performed DRE and sorted the patients according to the 1992 American Joint Committee on Cancer Classification for prostate cancer. Both the percentage...