Search results for: Barry M. Goldstein

Items from 1 to 7 out of 7 results

article

Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus : Insight into Thermostability and Cofactor Binding ^† ^, ^‡

Christopher Ceccarelli, Zhao-Xun Liang, Michael Strickler, Gerd Prehna, more

Biochemistry > 2004 > 43 > 18 > 5266 - 5277

article

Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101) ^†

Michael Strickler, Barry M. Goldstein, Kathleen Maxfield, Laura Shireman, more

Biochemistry > 2003 > 42 > 41 > 11943 - 11950

article

Active Site Mutations of Cytochrome P450cam Alter the Binding, Coupling, and Oxidation of the Foreign Substrates (R)- and (S)-2-Ethylhexanol

Kevin J. French, Dan A. Rock, Denise A. Rock, John I. Manchester, more

Archives of Biochemistry and Biophysics > 2002 > 398 > 2 > 188-197

Three factors are of primary importance with respect to designing efficient P450 biocatalysts. (1) The substrate must be oxidized at a significant rate. (2) The regioselectivity must heavily favor the desired product. (3) The enzyme must use the majority of the reducing equivalents from NADH or NADPH to produce product. The reaction we chose to study was oxidation of 2-ethylhexanol to 2-ethylhexanoic...

article

Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia ¹

Krzysztof W. Pankiewicz, Krystyna B. Lesiak-Watanabe, Kyoichi A. Watanabe, Steven E. Patterson, more

Journal of Medicinal Chemistry > 2002 > 45 > 3 > 703 - 712

article

Benign Synthesis of 2-Ethylhexanoic Acid by Cytochrome P450cam: Enzymatic, Crystallographic, and Theoretical Studies ^†

Kevin J. French, Michael D. Strickler, Dan A. Rock, Denise A. Rock, more

Biochemistry > 2001 > 40 > 32 > 9532 - 9538

article

A new C-nucleoside analogue of tiazofurin - synthesis and biological evaluation of 2-β-d-ribofuranosylimidazole-4-carboxamide (imidazofurin)

Palmarisa Franchetti, Stefano Marchetti, Loredana Cappellacci, Joel A. Yalowitz, more

Bioorganic & Medicinal Chemistry Letters > 2001 > 11 > 1 > 67-69

2-β-d-Ribofuranosylimidazole-4-carboxamide, an imidazole analogue of the antitumor agent tiazofurin, was synthesized and evaluated for the growth inhibitory activity of human myelogenous leukemia K562 cells.

article

Conformational constraints in NAD analogs: implications for dehydrogenase binding and specificity

Barry M. Goldstein, Thomas D. Colby

Advances in Enzyme Regulation > 2000 > 40 > 1 > 405-426

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Search results for: Barry M. Goldstein

Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus : Insight into Thermostability and Cofactor Binding † , ‡

Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101) †

Active Site Mutations of Cytochrome P450cam Alter the Binding, Coupling, and Oxidation of the Foreign Substrates (R)- and (S)-2-Ethylhexanol

Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia 1

Benign Synthesis of 2-Ethylhexanoic Acid by Cytochrome P450cam: Enzymatic, Crystallographic, and Theoretical Studies †

A new C-nucleoside analogue of tiazofurin - synthesis and biological evaluation of 2-β-d-ribofuranosylimidazole-4-carboxamide (imidazofurin)

Conformational constraints in NAD analogs: implications for dehydrogenase binding and specificity

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Crystal Structure and Amide H/D Exchange of Binary Complexes of Alcohol Dehydrogenase from Bacillus stearothermophilus : Insight into Thermostability and Cofactor Binding ^† ^, ^‡

Crystallographic Studies on the Complex Behavior of Nicotine Binding to P450cam (CYP101) ^†

Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia ¹

Benign Synthesis of 2-Ethylhexanoic Acid by Cytochrome P450cam: Enzymatic, Crystallographic, and Theoretical Studies ^†