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Extensive internalization into endothelial cells has been found for a water soluble amphipathic 26-mer β-sheet peptide (FLUOS-DPKGDPKGVTVTVTVTVTGKGDPKPD-NH 2 ; VT5). With the d-Val 13 ,d-Thr 14 di-d-amino acid analog of VT5 (DD-VT5), exhibiting an identical primary structure but no propensity to adopt a β-sheet conformation, only about 5% of the cellular uptake of VT5 was found...
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