Search results for: Bruno Bujoli

Items from 1 to 20 out of 38 results

article

Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties

Silvia Stella Ramirez Caballero, Daniel Ferri‐Angulo, Romain Debret, Fabien Granier, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 109 > 1 > 102 - 116

In the field of bone regenerative medicine, injectable calcium phosphate cements (CPCs) are used for decades in clinics, as bone void fillers. Most often preformed polymers (e.g., hyaluronic acid, collagen, chitosan, cellulose ethers…) are introduced in the CPC formulation to make it injectable and improve its cohesion. Once the cement has hardened, the polymer is simply trapped in the CPC structure...

article

In vivo resorption of injectable apatitic calcium phosphate cements: Critical role of the intergranular microstructure

Myriam Le Ferrec, Charlotte Mellier, Francois‐Xavier Lefèvre, Florian Boukhechba, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 2 > 367 - 376

The in vivo resorption rate of two injectable apatitic calcium phosphate cements used in clinics (Graftys® HBS and NORIAN®) was compared, using a good laboratory practice (GLP) study based on an animal model of critical‐sized bone defect. To rationalize the markedly different biological properties observed for both cements, key physical features were investigated, including permeability and water‐accessible...

article

Design and properties of a novel radiopaque injectable apatitic calcium phosphate cement, suitable for image‐guided implantation

Myriam Le Ferrec, Charlotte Mellier, Florian Boukhechba, Thomas Le Corroller, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 106 > 8 > 2786 - 2795

An injectable purely apatitic calcium phosphate cement (CPC) was successfully combined to a water‐soluble radiopaque agent (i.e., Xenetix^®), to result in an optimized composition that was found to be as satisfactory as poly(methyl methacrylate) (PMMA) formulations used for vertebroplasty, in terms of radiopacity, texture and injectability. For that purpose, the Xenetix dosage in the cement paste was...

article

Phosphonate‐Mediated Immobilization of Rhodium/Bipyridine Hydrogenation Catalysts

Florian Forato, Anouar Belhboub, Julien Monot, Marc Petit, more

Chemistry – A European Journal > 24 > 10 > 2457 - 2465

RhL₂ complexes of phosphonate‐derivatized 2,2′‐bipyridine (bpy) ligands L were immobilized on titanium oxide particles generated in situ. Depending on the structure of the bipy ligand—number of tethers (1 or 2) to which the phosphonate end groups are attached and their location on the 2,2′‐bipyridine backbone (4,4′‐, 5,5′‐, or 6,6′‐positions)—the resulting supported catalysts showed comparable chemoselectivity...

article

A straightforward approach to enhance the textural, mechanical and biological properties of injectable calcium phosphate apatitic cements (CPCs): CPC/blood composites, a comprehensive study

Charlotte Mellier, François-Xavier Lefèvre, Franck Fayon, Valérie Montouillout, more

Acta Biomaterialia > 2017 > 62 > C > 328-339

Two commercial formulations of apatitic calcium phosphate cements (CPCs), Graftys® Quickset (QS) and Graftys® HBS (HBS), similar in composition but with different initial setting time (7 and 15min, respectively), were combined to ovine whole blood. Surprisingly, although a very cohesive paste was obtained after a few minutes, the setting time of the HBS/blood composite dramatically delayed when compared...

article

Design and properties of novel gallium-doped injectable apatitic cements

Charlotte Mellier, Franck Fayon, Florian Boukhechba, Elise Verron, more

Acta Biomaterialia > 2015 > 24 > C > 322-332

Different possible options were investigated to combine an apatitic calcium phosphate cement with gallium ions, known as bone resorption inhibitors. Gallium can be either chemisorbed onto calcium-deficient apatite or inserted in the structure of β-tricalcium phosphate, and addition of these gallium-doped components into the cement formulation did not significantly affect the main properties of the...

article

Molybdocene dichloride intercalation into zirconium phosphate nanoparticles

Barbara Casañas-Montes, Agustín Díaz, Cindy Barbosa, Coralis Ramos, more

Journal of Organometallic Chemistry > 2015 > 791 > C > 34-40

Molybdocene dichloride (Cp₂MoCl₂), a metallocene dichloride currently being evaluated as potential anti-cancer drug, has been intercalated into zirconium phosphate, an inorganic layered nanomaterial. Hydrolysis of the chloride ligands appears to occur, leading to the formation of the monocation species ([Cp₂Mo(H₂O)(OH)]⁺), which intercalates into the ZrP layers by ion exchange. IR spectroscopy, X-ray...

chapter

Fine‐Tuning the Functionality of Inorganic Surfaces Using Phosphonate Chemistry

Bruno Bujoli, ClÉmence Queffelec

Tailored Organic‐Inorganic Materials > 299 - 318

A recent review has highlighted the current state of the art related to the modification of inorganic surfaces using phosphonic acids and their esters. This chapter gives evidence of the richness of applications, which can be considered using the resulting functional materials. These include protective layers, dye‐sensitized solar cells, photocatalytic systems, supported catalysts, and devices for...

article

High-frequency impedance measurement as a relevant tool for monitoring the apatitic cement setting reaction

Christelle Despas, Verena Schnitzler, Pascal Janvier, Franck Fayon, more

Acta Biomaterialia > 2014 > 10 > 2 > 940-950

This work reports the development of a relevant and general method, based on high-frequency impedance measurements, for the in situ monitoring of the alpha-tricalcium phosphate to calcium-deficient hydroxyapatite transformation that is the driving force of the hardening processes of some calcium phosphate cements (CPCs) used as bone substitutes. The three main steps of the setting reaction are identified...

article

Engineering of a phosphorylatable tag for specific protein binding on zirconium phosphonate based microarrays

Mathieu Cinier, Marc Petit, Frédéric Pecorari, Daniel R. Talham, more

JBIC Journal of Biological Inorganic Chemistry > 2012 > 17 > 3 > 399-407

A phosphorylatable tag was designed and fused at the C-terminal end of proteins, which allowed efficient and oriented immobilization of capture proteins on glass substrates coated with a zirconium phosphonate monolayer. The concept is demonstrated using Nanofitin directed against lysozyme. This peptide tag (DSDSSSEDE) contains four serines in an acidic environment, which favored its in vitro phosphorylation...

article

Characterization and Properties of Novel Gallium-Doped Calcium Phosphate Ceramics

Charlotte Mellier, Franck Fayon, Verena Schnitzler, Philippe Deniard, more

Inorganic Chemistry > 2011 > 50 > 17 > 8252 - 8260

article

Investigation of alendronate-doped apatitic cements as a potential technology for the prevention of osteoporotic hip fractures: Critical influence of the drug introduction mode on the in vitro cement properties

Verena Schnitzler, Franck Fayon, Christelle Despas, Ibrahim Khairoun, more

Acta Biomaterialia > 2011 > 7 > 2 > 759-770

Combination of a bisphosphonate (BP) anti-osteoporotic drug, alendronate, with an apatitic calcium phosphate cement does not significantly affect the main properties of the biomaterial, in terms of injectability and setting time, provided that the BP is introduced chemisorbed onto calcium-deficient apatite, one of the components of the cement. In contrast to other modes of introducing the BP into...

article

Na-doped β-tricalcium phosphate: physico-chemical and in vitro biological properties

Laëtitia Obadia, Marion Julien, Sophie Quillard, Thierry Rouillon, more

Journal of Materials Science: Materials in Medicine > 2011 > 22 > 3 > 593-600

Synthetic calcium phosphate ceramics as β-tricalcium phosphate (Ca₃(PO₄)₂; β-TCP) are currently successfully used in human bone surgery. The aim of this work was to evaluate the influence of the presence of sodium ion in β-TCP on its mechanical and biological properties. Five Na-doped-β-TCP [Ca_10.5−x/2Na_x(PO₄)₇, 0 ≤ x ≤ 1] microporous pellets were prepared via solid phase synthesis, and their physico-chemical...

article

In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite

Elise Verron, Olivier Gauthier, Pascal Janvier, Paul Pilet, more

Biomaterials > 2010 > 31 > 30 > 7776-7784

Resorbable calcium phosphate (CaP) biomaterials have demonstrated considerable efficacy in bone reconstructive surgery. Furthermore, bisphosphonates (BPs) are well known anti-resorptive agents largely used in clinical treatments for osteoporosis. An injectable BP-combined CaP matrix has been developed in order to biologically reinforce osteoporotic bone by increasing the bone fraction and improving...

article

Bisphosphonate Adaptors for Specific Protein Binding on Zirconium Phosphonate-based Microarrays

Mathieu Cinier, Marc Petit, Monique N. Williams, Roxane M. Fabre, more

Bioconjugate Chemistry > 2009 > 20 > 12 > 2270 - 2277

article

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

Samia Laïb, Borhane H. Fellah, Ahmed Fatimi, Sophie Quillard, more

Biomaterials > 2009 > 30 > 8 > 1568-1577

In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into rabbit bone defects in order to investigate its in vivo degradation. 1, 2, 3 and...

article

Nitrogen-Based Chirality Effects in Novel Mixed Phosphorus/Nitrogen Ligands Applied to Palladium-Catalyzed Allylic Substitutions

Verena Schnitzler, Guillaume Nonglaton, Hélène Roussière, Céline Maillet, more

Organometallics > 2008 > 27 > 22 > 5997 - 6004

article

Poly(dG) Spacers Lead to Increased Surface Coverage of DNA Probes: An XPS Study of Oligonucleotide Binding to Zirconium Phosphonate Modified Surfaces

Sarah M. Lane, Julien Monot, Marc Petit, Charles Tellier, more

Langmuir > 2008 > 24 > 14 > 7394 - 7399

article

Labeling of a self-hardening bone substitute using ruthenium tris-bipyridine complexes, for the analysis of its in vivo metabolism

Samia Laïb, Marc Petit, Ewen Bodio, Ahmed Fatimi, more

Comptes rendus - Chimie > 2008 > 11 > 6-7 > 641-649

A self-setting cellulose scaffold, used as a component of an injectable bone substitute, was labeled with ruthenium tris-bipyridine complexes functionalized by triethoxysilane groups. The labeling yield was found to vary according to the number and location of Si(OR) ₃ groups present on the ruthenium complex backbone. For label loadings, less than ∼0.1wt%, no significant modification of the...

article

Towards Zirconium Phosphonate-Based Microarrays for Probing DNA−Protein Interactions: Critical Influence of the Location of the Probe Anchoring Groups

Julien Monot, Marc Petit, Sarah M. Lane, Isabelle Guisle, more

Journal of the American Chemical Society > 2008 > 130 > 19 > 6243 - 6251

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INFONA - science communication portal

Search results for: Bruno Bujoli

Combination of biocompatible hydrogel precursors to apatitic calcium phosphate cements (CPCs): Influence of the in situ hydrogel reticulation on the CPC properties

In vivo resorption of injectable apatitic calcium phosphate cements: Critical role of the intergranular microstructure

Design and properties of a novel radiopaque injectable apatitic calcium phosphate cement, suitable for image‐guided implantation

Phosphonate‐Mediated Immobilization of Rhodium/Bipyridine Hydrogenation Catalysts

A straightforward approach to enhance the textural, mechanical and biological properties of injectable calcium phosphate apatitic cements (CPCs): CPC/blood composites, a comprehensive study

Design and properties of novel gallium-doped injectable apatitic cements

Molybdocene dichloride intercalation into zirconium phosphate nanoparticles

Fine‐Tuning the Functionality of Inorganic Surfaces Using Phosphonate Chemistry

High-frequency impedance measurement as a relevant tool for monitoring the apatitic cement setting reaction

Engineering of a phosphorylatable tag for specific protein binding on zirconium phosphonate based microarrays

Characterization and Properties of Novel Gallium-Doped Calcium Phosphate Ceramics

Investigation of alendronate-doped apatitic cements as a potential technology for the prevention of osteoporotic hip fractures: Critical influence of the drug introduction mode on the in vitro cement properties

Na-doped β-tricalcium phosphate: physico-chemical and in vitro biological properties

In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite

Bisphosphonate Adaptors for Specific Protein Binding on Zirconium Phosphonate-based Microarrays

The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering

Nitrogen-Based Chirality Effects in Novel Mixed Phosphorus/Nitrogen Ligands Applied to Palladium-Catalyzed Allylic Substitutions

Poly(dG) Spacers Lead to Increased Surface Coverage of DNA Probes: An XPS Study of Oligonucleotide Binding to Zirconium Phosphonate Modified Surfaces

Labeling of a self-hardening bone substitute using ruthenium tris-bipyridine complexes, for the analysis of its in vivo metabolism

Towards Zirconium Phosphonate-Based Microarrays for Probing DNA−Protein Interactions: Critical Influence of the Location of the Probe Anchoring Groups

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