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The coupling of surface plasmon resonance imaging (SPRi) and matrixassisted laser desorption ionization mass spectrometry (MALDI-MS) is an innovative approach for biomarker discovery in biological fluids. Multiplexed SPRi analysis allows the direct visualization and thermodynamic analysis of molecular avidity, and is advantageously used for ligand fishing on a SPRi-Biochip surface. MALDI-MS is a powerful...
Abstract: Basal cell carcinoma (BCC) can sometimes lead, through a possible invasion of the dermis and the subcutaneous tissue, to serious local damage to the patient. Several histological types of BCC are reported, among them, the superficial, nodular and infiltrative forms. This study reports the use of polarized Raman microspectroscopy on the nodular and superficial types to discriminate between...
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