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In recent years there has been growing interest in the spatial properties of osteocytes (including density and morphology) and how these potentially relate to adaptation, disease and aging. This interest has, in part, arisen from the availability of increasingly high-resolution 3D imaging modalities such as synchrotron radiation (SR) micro-CT. As resolution increases, field of view generally decreases...
As computational modeling becomes an increasingly common tool for probing the regulation of bone remodeling, the need for experimental data to refine and validate such models also grows. For example, van Oers et al. (R.F. van Oers, R. Ruimerman, B. van Rietbergen, P.A. Hilbers, R. Huiskes, Relating osteon diameter to strain. Bone 2008;43: 476–482.) recently described a mechanism by which osteon size...
Microstructural change associated with cortical bone remodeling has been extensively explored with 2D techniques. However, relatively little is known regarding the 3D dynamic microstructure of cortical bone. Therefore, we employed micro-CT imaging to investigate 3D remodeling-related change in the structure of cortical bone porosity across the human lifespan. Anterior femoral midshaft specimens (n=51...
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