Search results for: David L. Thomas

Items from 1 to 20 out of 156 results

article

Update on state‐of‐the‐art for arterial spin labeling (ASL) human perfusion imaging outside of the brain

Manuel Taso, Veronica Aramendía‐Vidaurreta, Erin K. Englund, Susan Francis, more

Magnetic Resonance in Medicine > 89 > 5 > 1754 - 1776

This review article provides an overview of developments for arterial spin labeling (ASL) perfusion imaging in the body (i.e., outside of the brain). It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group. In this review, we focus on specific challenges and developments tailored for ASL in a variety of...

article

Recent Technical Developments in ASL: A Review of the State of the Art

Luis Hernandez‐Garcia, Verónica Aramendía‐Vidaurreta, Divya S. Bolar, Weiying Dai, more

Magnetic Resonance in Medicine > 88 > 5 > 2021 - 2042

This review article provides an overview of a range of recent technical developments in advanced arterial spin labeling (ASL) methods that have been developed or adopted by the community since the publication of a previous ASL consensus paper by Alsop et al. It is part of a series of review/recommendation papers from the International Society for Magnetic Resonance in Medicine Perfusion Study Group...

article

Multi‐echo quantitative susceptibility mapping: how to combine echoes for accuracy and precision at 3 Tesla

Emma Biondetti, Anita Karsa, Francesco Grussu, Marco Battiston, more

Magnetic Resonance in Medicine > 88 > 5 > 2101 - 2116

Purpose To compare different multi‐echo combination methods for MRI QSM. Given the current lack of consensus, we aimed to elucidate how to optimally combine multi‐echo gradient‐recalled echo signal phase information, either before or after applying Laplacian‐base methods (LBMs) for phase unwrapping or background field removal. Methods Multi‐echo gradient‐recalled echo data were simulated in a numerical...

article

Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease

Samuel Shribman, Maggie Burrows, Rhian Convery, Martina Bocchetta, more

Movement Disorders > 37 > 8 > 1728 - 1738

Background Cognitive impairment is common in neurological presentations of Wilson's disease (WD). Various domains can be affected, and subclinical deficits have been reported in patients with hepatic presentations. Associations with imaging abnormalities have not been systematically tested. Objective The aim was to determine the neuroanatomical basis for cognitive deficits in WD. Methods We performed...

article

High‐resolution quantitative MRI of multiple sclerosis spinal cord lesions

Amy R. McDowell, Natalia Petrova, Daniele Carassiti, Marc E. Miquel, more

Magnetic Resonance in Medicine > 87 > 6 > 2914 - 2921

Purpose Validation of quantitative MR measures for myelin imaging in the postmortem multiple sclerosis spinal cord. Methods Four fixed spinal cord samples were imaged first with a 3T clinical MR scanner to identify areas of interest for scanning, and then with a 7T small bore scanner using a multicomponent‐driven equilibrium single‐pulse observation of T₁ and T₂ protocol to produce apparent proton...

article

Data‐driven staging of genetic frontotemporal dementia using multi‐modal MRI

Jillian McCarthy, Barbara Borroni, Raquel Sanchez‐Valle, Fermin Moreno, more

Human Brain Mapping > 43 > 6 > 1821 - 1835

Frontotemporal dementia in genetic forms is highly heterogeneous and begins many years to prior symptom onset, complicating disease understanding and treatment development. Unifying methods to stage the disease during both the presymptomatic and symptomatic phases are needed for the development of clinical trials outcomes. Here we used the contrastive trajectory inference (cTI), an unsupervised machine...

article

Post‐sequelae symptoms and comorbidities after COVID‐19

Priya Duggal, Tristan Penson, Hannah N. Manley, Candelaria Vergara, more

Journal of Medical Virology > 94 > 5 > 2060 - 2066

The frequency, severity, and forms of symptoms months after coronavirus 2019 (COVID‐19) are poorly understood, especially in community settings. To better understand and characterize symptoms months after community‐based COVID‐19, a retrospective cohort analysis was conducted. Three hundred and twenty‐eight consecutive persons with a positive test for SARS‐CoV‐2 in the Johns Hopkins Health System,...

article

Mortality among people who inject drugs: a prospective cohort followed over three decades in Baltimore, MD, USA

Jing Sun, Shruti H. Mehta, Jacquie Astemborski, Damani A. Piggott, more

Addiction > 117 > 3 > 646 - 655

Background and Aims During the past decades, people who inject drugs (PWID) have been impacted by the development of combination antiretroviral therapy (cART) to combat HIV/AIDS, the prescription opioid crisis and increased use of lethal synthetic opioids. We measured how these dynamics have impacted mortality among PWID in an urban US city. Design Prospective cohort study using data from the AIDS...

article

Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study

Carlo Wilke, Selina Reich, John C. Swieten, Barbara Borroni, more

Annals of Neurology > 91 > 1 > 33 - 47

Objective Although the presymptomatic stages of frontotemporal dementia (FTD) provide a unique chance to delay or even prevent neurodegeneration by early intervention, they remain poorly defined. Leveraging a large multicenter cohort of genetic FTD mutation carriers, we provide a biomarker‐based stratification and biomarker cascade of the likely most treatment‐relevant stage within the presymptomatic...

article

Sharing the cure: Building primary care and public health infrastructure to improve the hepatitis C care continuum in Maryland

Risha Irvin, Boatemaa Ntiri‐Reid, Mary Kleinman, Tracy Agee, more

Journal of Viral Hepatitis > 27 > 12 > 1388 - 1395

In 2014, trained healthcare provider capacity was insufficient to deliver care to an estimated 70 000 persons in Maryland with chronic hepatitis C virus (HCV) infection. The goal of Maryland Community Based Programs to Test and Cure Hepatitis C, a public health implementation project, was to improve HCV treatment access by expanding the workforce. Sharing the Cure (STC) was a package of services deployed...

article

Increased blood–brain barrier permeability to water in the aging brain detected using noninvasive multi‐TE ASL MRI

Yolanda Ohene, Ian F. Harrison, Phoebe G. Evans, David L. Thomas, more

Magnetic Resonance in Medicine > 85 > 1 > 326 - 333

Purpose A fundamental goal in the drive to understand and find better treatments for dementia is the identification of the factors that render the aging brain vulnerable to neurodegenerative disease. Recent evidence indicates the integrity of the blood–brain barrier (BBB) to be an important component of functional failure underlying age‐related cognitive decline. Practical and sensitive measurement...

article

Hepatitis C treatment uptake among people who inject drugs in the oral direct‐acting antiviral era

Oluwaseun Falade‐Nwulia, Rachel E. Gicquelais, Jacquie Astemborski, Sean D. McCormick, more

Liver International > 40 > 10 > 2407 - 2416

Background Increased uptake of hepatitis C virus (HCV) treatment among people who inject drugs (PWID) will be critical to achieve HCV elimination goals. There are limited data on HCV treatment uptake among PWID recruited from community‐based settings in the HCV direct‐acting antiviral (DAA) era. Methods We analysed data from PWID with HCV newly recruited into the Baltimore, Maryland‐based AIDS...

article

Investigating the accuracy and precision of TE‐dependent versus multi‐echo QSM using Laplacian‐based methods at 3 T

Emma Biondetti, Anita Karsa, David L. Thomas, Karin Shmueli

Magnetic Resonance in Medicine > 84 > 6 > 3040 - 3053

Purpose Multi‐echo gradient‐recalled echo acquisitions for QSM enable optimizing the SNR for several tissue types through multi‐echo (TE) combination or investigating temporal variations in the susceptibility (potentially reflecting tissue microstructure) by calculating one QSM image at each TE (TE‐dependent QSM). In contrast with multi‐echo QSM, applying Laplacian‐based methods (LBMs) for phase...

article

Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers

Gabriella Le Blanc, Vincent Jetté Pomerleau, Jillian McCarthy, Barbara Borroni, more

Annals of Neurology > 88 > 1 > 113 - 122

Objective C9orf72 expansion is the most common genetic cause of frontotemporal dementia (FTD). We examined aging trajectories of cortical thickness (CTh) and surface area in C9orf72 expansion adult carriers compared to healthy controls to characterize preclinical cerebral changes leading to symptoms. Methods Data were obtained from the Genetic Frontotemporal Dementia Initiative. T1‐weighted magnetic...

article

Network‐based recruitment of people who inject drugs for hepatitis C testing and linkage to care

Oluwaseun Falade‐Nwulia, Kathleen M. Ward, Sean McCormick, Shruti H. Mehta, more

Journal of Viral Hepatitis > 27 > 7 > 663 - 670

Although oral direct‐acting agent (DAA) therapies have the potential to reduce the burden of hepatitis C virus (HCV) infection, treatment uptake remains low, particularly among people who inject drugs (PWID). This study examined the feasibility of an innovative peer‐based recruitment strategy to engage PWID in HCV testing and treatment. We interviewed an initial set of HCV antibody‐positive PWID as...

article

Unreported alcohol use was common but did not impact hepatitis C cure in HIV‐infected persons who use drugs

Risha Irvin, Geetanjali Chander, Kathleen M. Ward, Sean Manogue, more

Journal of Viral Hepatitis > 27 > 5 > 476 - 483

We investigated the prevalence and impact of heavy alcohol use on the hepatitis C virus (HCV) care continuum amongst HIV/HCV co‐infected persons who use drugs. In the CHAMPS study, 144 HIV/HCV co‐infected persons were randomized to contingent cash incentives, peer mentors and usual care to evaluate the impact on HCV care. Alcohol use was ascertained using the 10‐item AUDIT (hazardous: male ≥8, female...

article

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI

Moss Y. Zhao, Lena Václavů, Esben T. Petersen, Bart J. Biemond, more

Magnetic Resonance in Medicine > 83 > 2 > 731 - 748

Purpose To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo‐QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post‐labeling delay pseudo‐continuous ASL (PCASL). Methods A model‐based method was developed to quantify CBF and arterial transit time (ATT) from Turbo‐QUASAR,...

article

Tractography-based parcellation does not provide strong evidence of anatomical organisation within the thalamus

Jonathan D. Clayden, David L. Thomas, Alexander Kraskov

NeuroImage > 2019 > 199 > C > 418-426

Connectivity-based parcellation of subcortical structures using diffusion tractography is now a common paradigm in neuroscience. These analyses often imply voxel-level specificity of connectivity, and the formation of compact, spatially coherent clusters is often taken as strong imaging-based evidence for anatomically distinct subnuclei in an individual. In this study, we demonstrate that internal...

article

Investigating the oxygenation of brain arteriovenous malformations using quantitative susceptibility mapping

Emma Biondetti, Alvaro Rojas-Villabona, Magdalena Sokolska, Francesca B. Pizzini, more

NeuroImage > 2019 > 199 > C > 440-453

Brain arteriovenous malformations (AVMs) are congenital vascular anomalies characterized by arteriovenous shunting through a network of coiled and tortuous vessels. Because of this anatomy, the venous drainage of an AVM is hypothesized to contain more oxygenated, arterialized blood than healthy veins. By exploiting the paramagnetic properties of deoxygenated hemoglobin in venous blood using magnetic...

article

In vivo demonstration of microscopic anisotropy in the human kidney using multidimensional diffusion MRI

Fabio Nery, Filip Szczepankiewicz, Leevi Kerkelä, Matt G. Hall, more

Magnetic Resonance in Medicine > 82 > 6 > 2160 - 2168

Purpose To demonstrate the feasibility of multidimensional diffusion MRI to probe and quantify microscopic fractional anisotropy (µFA) in human kidneys in vivo. Methods Linear tensor encoded (LTE) and spherical tensor encoded (STE) renal diffusion MRI scans were performed in 10 healthy volunteers. Respiratory triggering and image registration were used to minimize motion artefacts during the acquisition...

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INFONA - science communication portal

Search results for: David L. Thomas

Update on state‐of‐the‐art for arterial spin labeling (ASL) human perfusion imaging outside of the brain

Recent Technical Developments in ASL: A Review of the State of the Art

Multi‐echo quantitative susceptibility mapping: how to combine echoes for accuracy and precision at 3 Tesla

Neuroimaging Correlates of Cognitive Deficits in Wilson's Disease

High‐resolution quantitative MRI of multiple sclerosis spinal cord lesions

Data‐driven staging of genetic frontotemporal dementia using multi‐modal MRI

Post‐sequelae symptoms and comorbidities after COVID‐19

Mortality among people who inject drugs: a prospective cohort followed over three decades in Baltimore, MD, USA

Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study

Sharing the cure: Building primary care and public health infrastructure to improve the hepatitis C care continuum in Maryland

Increased blood–brain barrier permeability to water in the aging brain detected using noninvasive multi‐TE ASL MRI

Hepatitis C treatment uptake among people who inject drugs in the oral direct‐acting antiviral era

Investigating the accuracy and precision of TE‐dependent versus multi‐echo QSM using Laplacian‐based methods at 3 T

Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers

Network‐based recruitment of people who inject drugs for hepatitis C testing and linkage to care

Unreported alcohol use was common but did not impact hepatitis C cure in HIV‐infected persons who use drugs

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo‐QUASAR arterial spin labeling MRI

Tractography-based parcellation does not provide strong evidence of anatomical organisation within the thalamus

Investigating the oxygenation of brain arteriovenous malformations using quantitative susceptibility mapping

In vivo demonstration of microscopic anisotropy in the human kidney using multidimensional diffusion MRI

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