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Background
Erectile dysfunction (ED) is a common complication in patients with diabetes mellitus (DM) that severely affects the patients' quality of life. However, the effectiveness of oral phosphodiesterase type 5 inhibitors in these patients is poor. Sphingosine‐1‐phosphate (S1P) and S1P receptor 2 (S1PR2) are important factors regulating the Rho‑kinase pathway, and understanding these factors...
Background
Seminal plasma is a promising diagnostic fluid for male infertility. In assisted reproduction, the seminal plasma‐based characteristics of normozoospermic men achieving successful clinical pregnancy through rescue intracytoplasmic sperm injection after in vitro fertilization failure remain unclear.
Objective
To identify potential seminal plasma proteins to contribute to a new understanding...
Background
The clinical value of perineural invasion (PNI) in patients with localized prostate cancer (PCa) is widely explored. However, its role in metastatic PCa (mPCa) remains unknown.
Objectives
We aim to investigate the clinical significance of PNI in patients with mPCa.
Materials and methods
Data of 515 mPCa patients between 2012 and 2018 were retrospectively studied. PNI and its intensity...
Previously, we have demonstrated that human tissue kallikrein 1 (hKLK1) improves age‐related erectile dysfunction (ED). Autophagy has been implicated in age‐related diseases, including ED. However, the molecular mechanisms underlying hKLK1‐mediated amelioration of age‐related ED via regulation of autophagy remains unknown. To explore the potential mechanism, male wild‐type Sprague‐Dawley rats (WTR)...
Approximately 40% of middle‐aged men exhibit symptoms of late‐onset hypogonadism (LOH). However, the mechanism of androgen deficiency is still currently unclear. As shown in our previous studies, the SET protein is expressed in testicular Leydig cells and ovarian granule cells. This study was designed to investigate the effect of the SET protein on androgen production in Leydig cells. The AdCMV/SET...
Adipose‐derived stem cells (ADSCs) have recently been considered as a promising therapy for erectile dysfunction (ED). However, the mechanism of ADSC‐based therapy is unclear. Insulin‐like growth factor‐1 (IGF‐1), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) secreted by ADSCs were assessed in vitro. Sixteen 24‐month‐old male Sprague–Dawley rats were used for...
Sickle cell disease (SCD)‐associated priapism is characterized by decreased nitric oxide (NO) signaling and downregulated phosphodiesterase (PDE)5 protein expression and activity in the penis. Priapism is also associated with testosterone deficiency, but molecular mechanisms underlying testosterone effects in the penis in SCD are not known. Given the critical role of androgens in erection physiology...
The aim of this study was to develop nomograms for predicting prostate cancer and its zonal location using prostate‐specific antigen density, prostate volume, and their zone‐adjusted derivatives. A total of 928 consecutive patients with prostate‐specific antigen (PSA) less than 20.0 ng/mL, who underwent transrectal ultrasound‐guided transperineal 12‐core prostate biopsy at West China Hospital between...
Varicocoele is a common cause of male infertility. We undertook a population‐based cross‐sectional study to evaluate the prevalence of varicocoele among rural men in eastern China and its association with body mass index. A total of 39,559 rural men in six counties in Beijing, Guangdong and Shandong provinces were recruited from 2011 to 2012. The presence and severity of varicocoele were measured...
Possible hazardous health effects of radiofrequency electromagnetic radiations emitted from mobile phone on the reproductive system have raised public concern in recent years. This systemic review and meta‐analysis was prepared following standard procedures of the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement and checklist. Relevant studies...
Brain dysfunction in erectile dysfunction (ED) has been identified by multiple neuroimaging studies. A recent MRI study indicated grey matter alterations in ED patients. This study aims to investigate the microstructural changes of cerebral white matter (WM) in psychological ED patients and their possible correlations with clinical variables. Twenty‐seven psychological ED patients and 27 healthy subjects...
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