Search results for: Matias Vested

Items from 1 to 11 out of 11 results

article

Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study

Helene Dalsten, Vera Crone, Jacob Steinmetz, Christine L. Rosager, more

Acta Anaesthesiologica Scandinavica > 68 > 6 > 737 - 744

Background Suxamethonium is hydrolysed by butyrylcholinesterase (BChE) and a low BChE activity can result in a prolonged duration of action of suxamethonium. The BChE activity is reduced during pregnancy and postpartum period by up to 33%. However, it can also be reduced by mutations in the BChE gene. In this study, we assessed BChE activity and mutations in the BChE gene in pregnant and postpartum...

article

Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents III: The 2023 Geneva revision

Thomas Fuchs‐Buder, Sorin J. Brull, Malin Jonsson Fagerlund, J. Ross Renew, more

Acta Anaesthesiologica Scandinavica > 67 > 8 > 994 - 1017

The set of guidelines for good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents was developed following an international consensus conference in Copenhagen in 1996 (Viby‐Mogensen et al., Acta Anaesthesiol Scand 1996, 40, 59–74); the guidelines were later revised and updated following the second consensus conference in Stockholm in 2005 (Fuchs‐Buder et al., Acta Anaesthesiol Scand...

article

Collaboration for Evidence‐based Practice and Research in Anaesthesia (CEPRA): A consortium initiative for perioperative research

Anders Kehlet Nørskov, Janus Christian Jakobsen, Arash Afshari, Jannie Bisgaard, more

Acta Anaesthesiologica Scandinavica > 67 > 6 > 804 - 810

Evidence in perioperative care is insufficient. There is an urgent need for large perioperative research programmes, including pragmatic randomised trials, testing daily clinical treatments and unanswered question, thereby providing solid evidence for effects of interventions given to a large and growing number of patients undergoing surgery and anaesthesia. This may be achieved through large collaborations...

article

Rocuronium 0.3 or 0.9 mg/kg comparing onset time, duration of action, and intubating conditions in patients 80 years and older: A randomized study

Matias Vested, Pernille Pape, Camilla M. Kristensen, Felicia Dinesen, more

Acta Anaesthesiologica Scandinavica > 66 > 7 > 811 - 817

Background Limited data exist about the optimal dose of rocuronium for intubation in elderly patients. We hypothesized that rocuronium 0.9 mg/kg would lead to a shorter onset time than 0.3 mg/kg in patients above 80 years. Methods Thirty‐four patients were randomized to either rocuronium 0.3 or 0.9 mg/kg. The primary outcome was onset time defined as time to train‐of‐four (TOF) count of 0. Other...

article

A blinded randomized study comparing intubating conditions after either rocuronium 0.6 mg·kg⁻¹ or remifentanil 2 µg·kg⁻¹ in elderly patients

Matias Vested, Anne Marie Sørensen, Cecilie Bjerring, Rasmus E. Christensen, more

Acta Anaesthesiologica Scandinavica > 65 > 10 > 1367 - 1373

Background To facilitate tracheal intubation, either a neuromuscular blocking agent or a bolus dose of remifentanil can be administered. We hypothesized that rocuronium 0.6 mg·kg⁻¹ provided a larger proportion of excellent intubating conditions compared to remifentanil 2 µg·kg⁻¹ in patients above 80 years. Methods A total of 78 patients were randomized to either rocuronium 0.6 mg·kg⁻¹ or remifentanil...

article

Onset time and duration of action of rocuronium 0.6 mg/kg in patients above 80 years of age: A comparison with young adults

Cecilie Bjerring, Matias Vested, Tobias Arleth, Kirsten Eriksen, more

Acta Anaesthesiologica Scandinavica > 64 > 8 > 1082 - 1088

Background The number of elderly is increasing, and a large proportion of these people will require surgery and anaesthesia. However, little data exist regarding rocuronium in patients above 80 years of age. The aim of this study was to determine the onset time and duration of action for rocuronium 0.6 mg/kg in patients above 80 years compared with young adults. Methods This prospective observational...

article

Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study

Matias Vested, Mona Tarpgaard, Kirsten Eriksen, Lars S. Rasmussen

Acta Anaesthesiologica Scandinavica > 64 > 2 > 168 - 172

Background The aim of this quality assurance study was to determine the proportion of patients with residual block (train‐of‐four (TOF) ratio <0.9) upon conclusion of surgery after a bolus of cisatracurium 0.1 mg/kg. It was considered good quality if less than 10% of the study population had residual block upon conclusion of surgery. Methods A total of 40 patients ≤3 years of age scheduled for...

article

Reversal of mivacurium‐induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review

Joakim Holger Waage Brinch, Carl Martin Söderström, Mona Ring Gätke, Matias Vested Madsen

Acta Anaesthesiologica Scandinavica > 63 > 5 > 564 - 575

Background Mivacurium is a short‐acting non‐depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase. The neuromuscular block (NMB) can be antagonized with cholinesterase inhibitors (CHEI), but the short duration of action of mivacurium questions the need. This systematic review evaluated if the use of CHEIs (neostigmine, pyridostigmine or edrophonium) facilitates reversal of mivacurium‐induced...

article

Influence of intense neuromuscular blockade on surgical conditions during laparotomy: a pig model

Matias Vested Madsen, Anders Meller Donatsky, Bente Rona Jensen, Jacob Rosenberg, more

Journal of Anesthesia > 2015 > 29 > 1 > 15-20

Purpose Intense neuromuscular block may improve surgical conditions in ileus laparotomies; however, it is difficult to evaluate. The aim of this study was to investigate if neuromuscular block improved surgical conditions in pigs with artificial ileus laparotomy. Methods Six pigs were endotracheally intubated, mechanically ventilated, anesthetized with propofol and fentanyl, and randomized into...

article

Acupuncture Treatment for Pain: Systematic Review of Randomised Clinical Trials with Acupuncture, Placebo Acupuncture, and no Acupuncture Groups

K. Linde, Matias Vested Madsen, Peter C. Gøtzsche, Asbjørn Hrobjartsson

Deutsche Zeitschrift fuer Akupunktur > 2010 > 53 > 2 > 40-41

To study the analgesic effect of acupuncture and placebo acupuncture and to explore whether the type of the placebo acupuncture is associated with the estimated effect of acupuncture.Cochrane Library, Medline, Embase, Biological Abstracts, and PsycLIT.Three armed randomised clinical trials (including both a placebo or sham acupuncture group and a group receiving no acupuncture)Standardised mean differences...

article

Acupuncture Treatment for Pain: Systematic Review of Randomised Clinical Trials with Acupuncture, Placebo Acupuncture, and no Acupuncture Groups

Matias Vested Madsen, Peter C. Gøtzsche, Asbjørn Hrobjartsson, K. Linde

Deutsche Zeitschrift für Akupunktur > 2010 > 53 > 2 > 40-41

Aim To study the analgesic effect of acupuncture and placebo acupuncture and to explore whether the type of the placebo acupuncture is associated with the estimated effect of acupuncture. Data sources Cochrane Library, Medline, Embase, Biological Abstracts, and PsycLIT. Study selection Three armed randomised clinical trials (including both a placebo or sham acupuncture group and a group receiving...

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Keywords

NEUROMUSCULAR BLOCKADE (2)
NEUROMUSCULAR BLOCKING AGENTS (2)
ANAESTHESIOLOGY (1)
BUTYRYLCHOLINESTERASE (1)
COLLABORATION (1)
CONSORTIUM (1)
DEPTH OF NEUROMUSCULAR BLOCKADE (1)
ELDERLY (1)
ELDERLY PATIENTS (1)
LAPAROTOMY (1)
METHODOLOGY (1)
NEUROMUSCULAR MONITORING (1)
NEUROMUSCULAR RESEARCH (1)
PERIOPERATIVE MEDICINE (1)
PHARMACODYNAMICS (1)
PIG MODEL (1)
POSTOPERATIVE PULMONARY COMPLICATIONS (1)
POSTPARTUM (1)
PREGNANCY (1)
PSEUDOCHOLINESTERASE (1)
ROCURONIUM (1)
SURGICAL CONDITIONS (1)
SUXAMETHONIUM (1)
TIME COURSE OF NEUROMUSCULAR BLOCKADE (1)
TRACHEAL INTUBATING CONDITIONS (1)
YOUNG ADULTS (1)
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