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Macrophage inducible nitric oxide synthase is able to generate massive amounts of nitric oxide (NO) which contributes to the host immune defense against viruses and bacteria. Monocyte-macrophages stimulated with the bacterial wall component lipopolysaccharide (LPS) and cytokines such as interferon-γ (IFN-γ) express the inducible form of nitric oxide synthase (iNOS). Furthermore, tumor necrosis factor-α...
Flavonoids are potent antioxidants and have been associated with lowering the risk of cardiovascular diseases. In this study, the effect of flavonoids (monomers, dimers and a trimer) as well as French maritime pine bark extract, Pycnogenol, on NO production, tumor necrosis factor-α (TNF-α) secretion and nuclear factor (NF)-κB activity was compared. Monomers and dimers repressed NO production, TNF-α...
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