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The skeleton serves as an internal structural support system for vertebrates. It has mechanisms to grow and change in shape and size to suit varying stressors including the ability to resist the mechanical forces. In addition, bone is a major source of inorganic ions, and actively participates in the body’s calcium/phosphate balance. Bone tissue is continuously formed and remodeled throughout...
Osteoactivin (OA) is a novel glycoprotein that is highly expressed during osteoblast differentiation. Using Western blot analysis, our data show that OA protein has two isoforms, one is transmembranous and the other is secreted into the conditioned medium of primary osteoblasts cultures. Fractionation of osteoblast cell compartments showed that the mature, glycosylated OA isoform of 115 kDa is found...
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