Search results for: L. Bognar

Items from 1 to 11 out of 11 results

chapter

Reference database driven statistical analysis of automated frameless CT-MRI registration developed for radiosurgical investigations

G. Opposits, S.A. Kis, T. Spisak, E. Berenyi, more

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC) > 2780 - 2782

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference (2012 NSS/MIC)

The aims of this study were (1) to describe statistically the fluctuation of the goodness of automated CT-MRI registration method (2) to evaluate a numerical parameter, scaled to [0,1] interval (lambda), for characterizing the population level accuracy of any automated CT-MRI registration algorithm on voxel similarity basis. The population level distribution of cross-correlation values between the...

article

Fusionless posterior hemivertebra resection in a 2-year-old child with 16 years follow-up

D. Jeszenszky, T. F. Fekete, F. S. Kleinstueck, D. Haschtmann, more

European Spine Journal > 2012 > 21 > 8 > 1471-1476

Purpose We present the case of a 2-year-old patient with congenital scoliosis due to a lumbar hemivertebra. The current gold standard treatment of such an abnormality would be hemivertebra resection and short level posterior spinal fusion. However, due to the young age of the patient, we considered that application of a fusionless solution might offer advantages in terms of retaining normal segmental...

article

Binding of ATP as Well as Tetrahydrofolate Induces Conformational Changes in Lactobacillus casei Folylpolyglutamate Synthetase in Solution ^†

Yi Sheng, Hermia Ip, Jun Liu, Alan Davidson, more

Biochemistry > 2003 > 42 > 6 > 1537 - 1543

article

Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding

Yi Sheng, Jennifer A. Cross, Yang Shen, Clyde A. Smith, more

Archives of Biochemistry and Biophysics > 2002 > 402 > 1 > 94-103

Site-directed mutagenesis was performed on Glu143, an essential amino acid in Lactobacillus casei folylpolyglutamate synthetase (FPGS) and the structurally equivalent residue, Glu146, in Escherichia coli FPGS. Glu143 is positioned near the P-loop and interacts with the Mg ² ⁺ of Mg NTP-binding proteins. We have solved the structure of the E143A mutant of L. casei FPGS in the presence of...

article

Folate-binding triggers the activation of folylpolyglutamate synthetase11Edited by I. Wilson

Xiaolin Sun, Jennifer A Cross, Andrew L Bognar, Edward N Baker, more

Journal of Molecular Biology > 2001 > 310 > 5 > 1067-1078

Folic acid is an essential vitamin for normal cell growth, primarily through its central role in one-carbon metabolism. Folate analogs (antifolates) are targeted at the same reactions and are widely used as therapeutic drugs for cancer and bacterial infections. Effective retention of folates in cells and the efficacy of antifolate drugs both depend upon the addition of a polyglutamate tail to the...

article

Structural and functional similarities in the ADP-forming amide bond ligase superfamily: implications for a substrate-induced conformational change in folylpolyglutamate synthetase11Edited by I. A. Wilson

Yi Sheng, Xiaolin Sun, Yang Shen, Andrew L Bognar, more

Journal of Molecular Biology > 2000 > 302 > 2 > 425-438

Comparison of the three-dimensional structures of folylpolyglutamate synthetase (FPGS) and the bacterial cell wall ligase UDP-N-acetylmuramoyl-l-alanine:d-glutamate ligase (MurD) reveals that these two enzymes have a remarkable structural similarity despite a low level of sequence identity. Both enzymes have a modular, multi-domain structure and catalyse a similar ATP-dependent reaction involving...

article

Disruption of Cytoplasmic and Mitochondrial Folylpolyglutamate Synthetase Activity in Saccharomyces cerevisiae

Leroi DeSouza, Yang Shen, Andrew L. Bognar

Archives of Biochemistry and Biophysics > 2000 > 376 > 2 > 299-312

Similar to other eukaryotes, yeasts have parallel pathways of one-carbon metabolism in the cytoplasm and mitochondria and have folylpolyglutamate synthetase activity in both compartments. The gene encoding folylpolyglutamate synthetase is MET7 (also referred to as MET23) on chromosome XV and appears to encode both the cytoplasmic and mitochondrial forms of the enzyme. In order to determine the metabolic...

article

The role of HPG axis and the limbic system in modulation of emotion and motivation (animal model)

H. Lukács, P. Tóth, L. Bognár, A. Gachaly, more

Biological Psychiatry > 1997 > 42 > 1 Supplement 1 > 39S-40S

article

Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis

Nicole Monschau, K.-Peter Stahmann, Hermann Sahm, J. Bryan McNeil, more

FEMS Microbiology Letters > 1997 > 150 > 1 > 55-60

Determination of enzyme-specific activities revealed that GLY1 encodes a threonine aldolase (TA) in Saccharomyces cerevisiae. A knock-out mutant auxotrophic for glycine lacked detectable activity. After transformation with YEp24GLY1 glycine prototrophy was restored and TA-specific activity was 16-fold higher than in the wild type. Growth experiments using glucose as the sole carbon source showed that...

article

Potentiels evoques auditifs precoces et de latence moyenne dans les lesions des voies auditives centrales.

C Fischer, L Bognar, D Muguet, G Fischer, more

Neurophysiologie Clinique / Clinical Neurophysiology > 1997 > 27 > 2 > 151

Les potentiels auditifs precoces (PEAP) et de latence moyenne (PEALM) permettent d'evaluer l'etat fonctionnel de la voie auditive centrale. Ils ont ete enregistres chez 40 patients ayant une lesion vasculaire ou postchirurgicale de la voie auditive centrale, documentee par l'IRM dans tous les cas.Les lesions du cortex auditif temporal et des radiations auditives comportent toutes une reduction significative...

article

Cloning, and molecular characterization of the GCV1 gene encoding the glycine cleavage T-protein from Saccharomyces cerevisiae

J.Bryan McNeil, Fang-rong Zhang, Brian V. Taylor, David A. Sinclair, more

Gene > 1997 > 186 > 1 > 13-20

We have isolated the gene encoding the glycine cleavage T-protein (GCV1) of the yeast Saccharomyces cerevisiae and shown through gene disruption and enzyme assays that inactivation of GCV1 destroys glycine cleavage function. A DNA fragment encoding the GCV1 gene was cloned by PCR amplification using degenerate oligodeoxyribonucleotides, and the cloned fragment was used as a probe to isolate the complete...

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