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We have previously shown that immunization to homologous LDL reduces neointimal thickening after balloon injury in hypercholesterolemic rabbits. In this study we investigated the effects of the immune system on intimal thickening after arterial injury in RAG (recombination activating gene)-1 deficient (-/-) mice. The arterial injury was induced by placing of a plastic cuff around the carotid artery...
We used an atherogenic ApoE-deficient mouse (ApoE KO) model to determine whether treatment with recombinant (ApoM) would restore the impaired endothelium-dependent vasodilatation in these mice. Untreated ApoE KO mice, fed a high-cholesterol diet, were sacrificed at 25 (ApoE25, n = 5) or 30 weeks (ApoE30, n = 6). Treated mice received 20 (ApoM 20, n = 9) or 80 mg/kg/dose (ApoM 80, n = 10) of ApoM...
We previously demonstrated antiatherogenic effects of reconstituted high density lipoprotein (HDL) using the recombinant apolipoprotein (apo) A-I mutant, apoA-I Milano (ApoM), complexed with the phospholipid carrier DMPC. In this study, we examined whether ApoM has any effects on lysophosphatidylcholine (LPC)-induced impairment of endothelium-dependent vasodilatation...
We tested the hypothesis that recombinant apolipoprotein A-I Milano -phospholipid complex (A-I M -PC) would inhibit aortic atherosclerosis (AS) in apoE-deficient mice. Control apoE-deficient mice, fed a high-cholesterol diet, were sacrificed at 20 (n = 8) or 25 weeks (N = 7). Treated mice received 40 mg/kg/dose A-I M -PC (n = 15) or PC alone (n =...
Membrane-type matrix metalloproteinase (MT-MMP) is a novel membrane bound member of the MMP family that was identified in tumor cells in 1994. MT-MMP activates pro-MMP-2 thus facilitating tumor cell invasion and metastasis. Various MMP's are expressed in human atherosclerotic plaques where they may play a role in matrix remodeling and plaque disruption, but expression of MT-MMP in human atherosclerotic...
Elevated plasma apolipoprotein (apo)-B level is a known risk for atherosclerotic CAD, however its relationship to arterial thrombosis is unknown. We prospectively assessed apo-B and platelet-dependent thrombosis (PDT) in 42 stable CAD patients on aspirin and lipid-lowering therapy, by exposing porcine aortic media to their flowing nonanticuagulated venous blood for 5 minutes at a shear rate of 800...
The comparison of fluorescein polarization spectra in living cells and in isolated subcellular structures identified the mitochondria as the cytoplasmic domain in which on excitation at 470 nm the sharp fluorescein emission polarization peak at 510 nm is formed. Changes in the emission polarization peak during the cell cycle or those induced by growth stimulators and inhibitors reflect structural...
Changes in the fluorescein fluorescence emission and excitation polarization spectra in synchronized cultured S3 fibroblasts at G1, mid-S, and mitosis, as well as in human lymphocytes before and after stimulation with mitogens, were studied. In contrast to those measured in aqueous solutions the emission and excitation polarization spectra in living cells exhibit a wavelength dependence characteristic...
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