Search results for: Charles A. Marsden

Items from 1 to 20 out of 51 results

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Sensory gating, Cannabinoids and Schizophrenia

Dilshani W.N. Dissanayake, Robert Mason, Charles A. Marsden

Neuropharmacology > 2013 > 67 > Complete > 66-77

Sensory gating, a mandatory process in early information processing, has been found to be defective in neuropsychiatric diseases such as schizophrenia. Understanding the neurobiology of sensory gating may provide insight into unravelling the neurobiology of information processing and to yet unanswered queries on the pathophysiology of disabling neuropsychiatric diseases. The endocannabinoid system...

article

The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat

Neda Assareh, Maha M. ElBatsh, Charles A. Marsden, David A. Kendall

Pharmacology, Biochemistry and Behavior > 2012 > 100 > 3 > 506-512

Recent findings indicate that CB1 receptor blockade might be relevant to the action of antidepressant drugs as inhibition of endocannabinoid function can increase synaptic availability of neurotransmitters; an effect also seen with chronic antidepressant drug treatment. Chronic treatments with established antidepressants also lead to raised brain BDNF levels. The aim of this study was to compare the...

article

Reply to the comment on: ‘Anxiogenic-like effects of chronic cannabidiol administration in rats’ (Elbatsh MM, Assareh N, Marsden CA and Kendall DA; Psychopharmacology 2012)

Maha Mohamed Elbatsh, Neda Assareh, Charles A. Marsden, David A. Kendall

Psychopharmacology > 2012 > 222 > 4 > 727-727

article

Serotonin: The New Wave

Charles A. Marsden, Sheryl G. Beck

Neuropharmacology > 2011 > 61 > 3 > 347

article

Influence of social isolation in the rat on serotonergic function and memory – Relevance to models of schizophrenia and the role of 5-HT6 receptors

Charles A. Marsden, Madeleine V. King, Kevin C.F. Fone

Neuropharmacology > 2011 > 61 > 3 > 400-407

There is increasing awareness of the importance that early environmental factors have on brain development and their role in the neurobiology of neurodevelopmental disorders including schizophrenia. The isolation reared rat attempts to model adverse effects that human social isolation (absence of social contact) can have on normal brain development. The isolation reared rat also models aspects of...

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Acute effects of bergamot oil on anxiety‐related behaviour and corticosterone level in rats

Somrudee Saiyudthong, Charles A. Marsden

Phytotherapy Research > 25 > 6 > 858 - 862

Bergamot essential oil (BEO), Citrus aurantium subsp. bergamia (Risso) Wright & Arn. (Rutaceae), is used widely in aromatherapy to reduce stress and anxiety despite limited scientific evidence. A previous study showed that BEO significantly increased gamma‐aminobutyric acid levels in rat hippocampus, suggesting potential anxiolytic properties. The aim of this study was to investigate the effect...

article

Depolarizing and calcium‐mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices

Sarir Sarmad, Stephen P. H. Alexander, David A. Barrett, Charles A. Marsden, more

Journal of Neurochemistry > 117 > 4 > 665 - 677

J. Neurochem. (2011) 117, 665–677. AbstractThe concentrations of the endocannabinoids 2‐arachidonoylglycerol (2‐AG) and N‐arachidonylethanolamine (anandamide) were examined in rat brain cerebral cortex slices and surrounding medium. Basal concentrations of endocannabinoids were similar to those identified previously in rat brain, with anandamide content being much lower (19 pmol/g) than that of 2‐AG...

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Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats

Ratchanee Rodsiri, Clare Spicer, A. Richard Green, Charles A. Marsden, more

Psychopharmacology > 2011 > 213 > 2-3 > 365-376

Rationale 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia. Objective This study examined whether the acute functional changes of locomotor activity and body temperature are related to enhanced 5-HT release induced by MDMA. Methods We concomitantly measured changes in extraneuronal 5-HT by in vivo...

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Early life programming of fear conditioning and extinction in adult male rats

Carl W. Stevenson, Clare H. Spicer, Rob Mason, Charles A. Marsden

Behavioural Brain Research > 2009 > 205 > 2 > 505-510

The early rearing environment programs corticolimbic function and neuroendocrine stress reactivity in adulthood. Although early environmental programming of innate fear has been previously examined, its impact on fear learning and memory later in life remains poorly understood. Here we examined the role of the early rearing environment in programming fear conditioning and extinction in adult male...

article

Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: Further evaluation of a potential model of ADHD

Katherine N. Hewitt, Charles A. Marsden, Chris P. Hollis, Kevin C.F. Fone

Neuropharmacology > 2009 > 57 > 7-8 > 678-686

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder characterised by excessive levels of hyperactivity, inattentiveness and impulsivity. Stimulant drugs which increase dopamine neurotransmission are treatments for ADHD. Hypodopaminergic fronto-striatal function with associated overactivity of the dopamine transporter (DAT) represents one possible neurobiological mechanism...

article

Attention deficit hyperactivity disorder (ADHD): Improved understanding and novel drug treatment

Charles A. Marsden

Neuropharmacology > 2009 > 57 > 7-8 > 577-578

article

Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast

Neil Easton, Fiona H. Marshall, Charles A. Marsden, Kevin C.F. Fone

Neuropharmacology > 2009 > 57 > 7-8 > 653-664

Methylphenidate (Ritalin ^® ) is a selective dopamine reuptake inhibitor and an effective treatment for attention deficit hyperactivity disorder (ADHD) however the anatomical foci and neuronal circuits involved in these therapeutic benefits are unclear. This study determines the temporal pattern of brain regional activity change produced by systemic administration of a therapeutically relevant...

article

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

Massimiliano Bianchi, Kevin C.F. Fone, Ajit J. Shah, Alan R. Atkins, more

European Neuropsychopharmacology > 2009 > 19 > 11 > 778-790

Social isolation from weaning in rats produces behavioural and hippocampal structural changes at adulthood. Here, rats were group or isolation reared for eight-weeks. Following the initial four-week period of rearing, fluoxetine (10mg/kg i.p.) was administered for 28days. Changes in recognition memory, hippocampal monoamines, and cytoskeletal microtubules were investigated. Isolation-rearing for four-...

article

Effects of phencyclidine on auditory gating in the rat hippocampus and the medial prefrontal cortex

Dilshani W.N. Dissanayake, Margarita Zachariou, Charles A. Marsden, Robert Mason

Brain Research > 2009 > 1298 > Complete > 153-160

Sensory gating can be assessed using an auditory conditioning (C)-test (T) paradigm which measures the reduction in the auditory-evoked response produced by a test stimulus following a conditioning stimulus. Schizophrenic patients demonstrate absence of gating while dysfunction in glutamatergic neurotransmission is implicated in the pathophysiology of schizophrenia. This study examined the effect...

article

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels

Marie-Christine Pardon, Sarir Sarmad, Ivan Rattray, Timothy E. Bates, more

Neurobiology of Aging > 2009 > 30 > 7 > 1099-1113

Environmental factors (e.g. stress, exercise, enrichment) are thought to play a role in the development of Alzheimer's disease later in life. We investigated the influence of repeated novel cage exposure on the development of early Alzheimer's-like pathology in adult (4 months old) double transgenic mice over-expressing the amyloid precursor protein and presenilin-1 genes (TASTPM mouse line). The...

article

Neonatal maternal separation alters reward-related ultrasonic vocalizations in rat dams

Carl W. Stevenson, Paul E. Goodwin, Beth Tunstall, Clare H. Spicer, more

Behavioural Brain Research > 2009 > 200 > 1 > 232-236

We examined the effects of brief or long durations of repeated maternal separation (MS) on ultrasonic vocalizations (USVs) in rat dams. 50-kHz USVs putatively identified as maternal in origin were emitted only immediately after pups were returned following MS. Maternal USV emission also depended on separation duration and pup age. Given that 50-kHz USVs are emitted in response to rewarding stimuli,...

article

Early life programming of innate fear and fear learning in adult female rats

Carl W. Stevenson, John P. Meredith, Clare H. Spicer, Rob Mason, more

Behavioural Brain Research > 2009 > 198 > 1 > 51-57

The early rearing environment can impact on emotional reactivity and learning later in life. In this study the effects of neonatal maternal separation (MS) on innate fear and fear learning were assessed in the adult female rat. Pups were subjected to MS (360min), brief handling (H; 15min), or animal facility rearing (AFR) on post-natal days 2–14. In the first experiment, innate fear was tested in...

article

MDMA: On the translation from rodent to human dosing

A. Richard Green, Johan Gabrielsson, Charles A. Marsden, Kevin C. F. Fone

Psychopharmacology > 2009 > 204 > 2 > 375-378

article

Auditory gating in rat hippocampus and medial prefrontal cortex: Effect of the cannabinoid agonist WIN55,212-2

Dilshani W.N. Dissanayake, Margarita Zachariou, Charles A. Marsden, Robert Mason

Neuropharmacology > 2008 > 55 > 8 > 1397-1404

Sensory gating can be assessed in rodents and humans using an auditory conditioning (C)–test (T) paradigm, with schizophrenic patients exhibiting a loss of gating. Dysregulation of the endocannabinoid system has been proposed to be involved in the pathogenesis of schizophrenia. We studied auditory gating and the effects of the cannabinoid agonist WIN55,212-22 on gating in CA3 and dentate gyrus (DG)...

article

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

Madeleine V. King, Charles A. Marsden, Kevin C.F. Fone

Trends in Pharmacological Sciences > 2008 > 29 > 9 > 482-492

The serotonergic system is implicated in the neurobiological control of learning and memory, both in healthy individuals and pathological disorders, although the underlying mechanisms remain elusive. After the cloning and characterization of serotonin, or 5-hydroxytryptamine (5-HT), receptors and the resultant development of selective agonist and antagonist compounds and transgenic receptor-knockout...

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Search results for: Charles A. Marsden

Sensory gating, Cannabinoids and Schizophrenia

The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat

Reply to the comment on: ‘Anxiogenic-like effects of chronic cannabidiol administration in rats’ (Elbatsh MM, Assareh N, Marsden CA and Kendall DA; Psychopharmacology 2012)

Serotonin: The New Wave

Influence of social isolation in the rat on serotonergic function and memory – Relevance to models of schizophrenia and the role of 5-HT6 receptors

Acute effects of bergamot oil on anxiety‐related behaviour and corticosterone level in rats

Depolarizing and calcium‐mobilizing stimuli fail to enhance synthesis and release of endocannabinoids from rat brain cerebral cortex slices

Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats

Early life programming of fear conditioning and extinction in adult male rats

Behavioural characterisation of the effects of acute and repeated administration of GBR 12909 in rats: Further evaluation of a potential model of ADHD

Attention deficit hyperactivity disorder (ADHD): Improved understanding and novel drug treatment

Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast

Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats

Effects of phencyclidine on auditory gating in the rat hippocampus and the medial prefrontal cortex

Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels

Neonatal maternal separation alters reward-related ultrasonic vocalizations in rat dams

Early life programming of innate fear and fear learning in adult female rats

MDMA: On the translation from rodent to human dosing

Auditory gating in rat hippocampus and medial prefrontal cortex: Effect of the cannabinoid agonist WIN55,212-2

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

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