Search results for: Maria A. Pronzato

Items from 1 to 20 out of 24 results

article

HO‐1 downregulation favors BRAF^V600 melanoma cell death induced by Vemurafenib/PLX4032 and increases NK recognition

Anna L. Furfaro, Selene Ottonello, Giulia Loi, Irene Cossu, more

International Journal of Cancer > 146 > 7 > 1950 - 1962

Heme oxygenase 1 (HO‐1) plays a pivotal role in preventing cell damage. Indeed, through the antioxidant, antiapoptotic and anti‐inflammatory properties of its metabolic products, it favors cell adaptation against different stressors. However, HO‐1 induction has also been related to the gain of resistance to therapy in different types of cancers and its involvement in cancer immune‐escape has been...

article

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells

Elisa Calcagno, Francesca Caudano, Mario Passalacqua, Maria A. Pronzato, more

Mechanisms of Ageing and Development > 2017 > 166 > C > 1-5

Long-term potentiation (LTP) and the process of memory formation require activation of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) pathways. Notably, recent evidence indicated that both cyclic nucleotides boost the production of amyloid-beta (Aβ) peptides. In particular, cAMP was shown to favor hippocampal LTP by stimulating the synthesis of the amyloid precursor...

article

HO-1 down-regulation increases the efficacy of BRAFV600E inhibition-based therapy in primary melanoma cells

Anna Lisa Furfaro, Gabriella Pietra, Irene Cossu, Umberto M. Marinari, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S64

Heme oxygenase 1 (HO-1) plays a key role in maintaining cell redox balance. Under stress conditions, HO-1 is up-regulated and generates bilirubin, ferritin and carbon monoxide, with antioxidant, antiapoptotic and anti-inflammatory properties [Jozkowicz et al., 2007]. HO-1 induction favors cancer progression [Furfaro et al., 2016] and its involvement in tumor resistance to therapy [Was et al., 2006]...

article

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

Sabrina Piras, Lorenzo Brondolo, Anna Lisa Furfaro, Mario Passalacqua, more

Free Radical Biology and Medicine > 2017 > 108 > S1 > S80

Neuronal adaptation to oxidative stress is crucial to prevent degenerative diseases. The role of the Nrf2/HO-1 system in cell response to hydrogen peroxide (H₂O₂) has been investigated using SH-SY5Y neuroblastoma cells as undifferentiated or after differentiation with all-trans retinoic acid (ATRA). We showed that undifferentiated cells resisted to oxidative stimulus and up-regulated HO-1 which was...

article

ATRA-induced neuronal differentiation reduces cell ability to adapt to oxidative stress: role of Nrf2 and HO-1

Sabrina Piras, Anna Lisa Furfaro, Cinzia Domenicotti, Nicola Traverso, more

Free Radical Biology and Medicine > 2016 > 96 > S1 > S49

article

Amyloid β: Walking on the dark side of the moon

Ernesto Fedele, Daniela Rivera, Barbara Marengo, Maria A. Pronzato, more

Mechanisms of Ageing and Development > 2015 > 152 > C > 1-4

For some decades, amyloid β (Aβ) has only been considered as a cytotoxic peptide, putative cause and marker of Alzheimer’s disease (AD). Today, however, a considerable amount of evidence goes against the classical amyloid hypothesis and illustrates a new picture in which the Aβ loss of function, rather than its accumulation, has a pathogenic role in AD. In this concise review, we summarize some highlights...

article

Monomeric Aβ1–42 and RAGE: key players in neuronal differentiation

Sabrina Piras, Anna L. Furfaro, Alessandra Piccini, Mario Passalacqua, more

Neurobiology of Aging > 2014 > 35 > 6 > 1301-1308

The aggregation of amyloid-β (Aβ) peptides plays a crucial role in the onset and progression of Alzheimer's disease. Monomeric form of Aβ, indeed, could exert a physiological role. Considering the anti-oligomerization property of all-trans retinoic acid (ATRA), the involvement of monomeric Aβ1–42 in ATRA-induced neuronal differentiation has been investigated. Four-day ATRA treatment increases β-secretase...

article

Processing of the amyloid precursor protein: Role of protein kinase C and myosin IIB

Francesca Argellati, Cinzia Domenicotti, Maria A. Pronzato, Umberto M. Marinari, more

Alzheimer's & Dementia > 2009 > 5 > 4(S) > P493

article

Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma

Barbara Marengo, Chiara De Ciucis, Daniela Verzola, Vito Pistoia, more

Free Radical Biology and Medicine > 2008 > 44 > 3 > 474-482

Glutathione (GSH) depletion is widely used to sensitize cells to anticancer treatment inducing the progression of programmed cell death and overcoming chemoresistance. It has been reported that neuroblastoma cells with MYCN amplification are unable to start TRAIL-dependent death and MYCN, in concert with cytotoxic drugs, efficiently induces the mitochondrial pathway of apoptosis through oxidative...

article

PKC signaling in oxidative hepatic damage

Mariapaola Nitti, Maria A. Pronzato, Umberto M. Marinari, Cinzia Domenicotti

Molecular Aspects of Medicine > 2008 > 29 > 1-2 > 36-42

Protein kinase C (PKC) is a family of isoenzymes differently involved in cell response to injury and many studies describe their role as “stress sensors”. Oxidative stress is strictly involved in the pathogenesis of chronic liver diseases including alcohol- or drug-induced hepatotoxicity, iron overload, hepatitis and hepatocarcinoma development, but molecular mechanisms are not really defined. A crucial...

article

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-β deposition in N2a cells

Sara Massone, Francesca Argellati, Mario Passalacqua, Andrea Armirotti, more

Biochemical and Biophysical Research Communications > 2007 > 362 > 3 > 633-638

The Alzheimer’s disease (AD) brain pathology is characterized by extracellular deposits of amyloid-β (Aβ) peptides and intraneuronal fibrillar structures. These pathological features may be functionally linked, but the mechanism by which Aβ accumulation relates to neuronal degeneration is still poorly understood. Aβ peptides are fragments cleaved from the amyloid precursor protein (APP), a transmembrane...

article

In vitro effect of PPAR-γ2 Pro12Ala polymorphism on the deposition of Alzheimer's amyloid-β peptides

Cristina d'Abramo, Jean-Marc Zingg, Antonio Pizzuti, Francesca Argellati, more

Brain Research > 2007 > 1173 > Complete > 1-5

Mounting evidence suggests that peroxisome proliferator-activated receptor-γ (PPAR-γ) is involved in the modulation of pathogenic events related to Alzheimer's disease (AD). Such events would include the cerebral deposition of amyloid-β (Aβ) and the consequent local inflammatory response. PPAR-γ has been shown to act on both fronts, reducing either the secretion of Aβ or the expression of pro-inflammatory...

article

Vitamin E and neurodegenerative diseases

Roberta Ricciarelli, Francesca Argellati, Maria A. Pronzato, Cinzia Domenicotti

Molecular Aspects of Medicine > 2007 > 28 > 5-6 > 591-606

Vitamin E is essential for neurological function. This fact, together with a growing body of evidence indicating that neurodegenerative processes are associated with oxidative stress, lead to the convincing idea that several neurological disorders may be prevented and/or cured by the antioxidant properties of vitamin E.In this review, some aspects related to the role of vitamin E against Alzheimer’s...

article

PKC delta and NADPH oxidase in AGE-induced neuronal death

Mariapaola Nitti, Anna L. Furfaro, Nicola Traverso, Patrizio Odetti, more

Neuroscience Letters > 2007 > 416 > 3 > 261-265

Advanced glycation end product (AGE) accumulation in brain is believed to contribute to neuronal death in several neurodegenerative diseases. Neurons exposed to AGEs undergo oxidative stress, but the molecular mechanisms able to induce ROS generation and cell death are not yet clear. In this work, we exposed SH-SY5Y neuroblastoma cells to glycated albumin, as a model of AGE-modified protein, and we...

article

Amyloid precursor protein processing: Role of peroxisome proliferator-activated receptor-gamma

Roberta Ricciarelli, Sara Massone, Cristina d’Abramo, Umberto M. Marinari, more

Alzheimer's & Dementia: The Journal of the Alzheimer's Association > 2006 > 2 > 3 Supplement > S539

article

Central role of PKCδ in glycoxidation-dependent apoptosis of human neurons

Mariapaola Nitti, Cristina d'Abramo, Nicola Traverso, Daniela Verzola, more

Free Radical Biology and Medicine > 2005 > 38 > 7 > 846-856

Accumulation of advanced glycation end products (AGEs) induces alterations in the intracellular redox balance, leading cells to functional injury. Current literature reports that intracellular signaling triggered by the interaction of AGEs with their specific receptors RAGEs depends on the cell type and the state of activation/stress. In this work, NT2 human neurons were exposed for 48 h to glycated...

article

CD36 overexpression in human brain correlates with β-amyloid deposition but not with Alzheimer's disease

Roberta Ricciarelli, Cristina d'Abramo, Jean-Marc Zingg, Luca Giliberto, more

Free Radical Biology and Medicine > 2004 > 36 > 8 > 1018-1024

Scavenger receptors recently have been related to Alzheimer's disease, although it is still unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory response to the deposition of amyloid β-protein (Aβ). In this study we demonstrate that CD36, a class B scavenger receptor, is highly expressed in the cerebral cortex of Alzheimer's disease patients and cognitively...

article

A novel role of protein kinase C-δ in cell signaling triggered by glutathione depletion

Cinzia Domenicotti, Barbara Marengo, Mariapaola Nitti, Daniela Verzola, more

Biochemical Pharmacology > 2003 > 66 > 8 > 1521-1526

Current evidence demonstrates that protein kinase C (PKC) belongs to a group of cell-signaling molecules that are sensitive targets for redox modifications and functional alterations that mediate oxidant-induced cellular responses. Our studies have demonstrated that diminished intracellular GSH was associated to inactivation of classic isoforms and increased activity of novel PKCs, and triggered molecular...

article

Oxidative Stress Increases Expression and Activity of BACE in NT ₂ Neurons

Elena Tamagno, Paola Bardini, Alessandra Obbili, Antonella Vitali, more

Neurobiology of Disease > 2002 > 10 > 3 > 279-288

Recently an aspartyl protease with β-secretase activity called BACE was identified. In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE). Exposure of NT ₂ neurons to the two classical pro-oxidant stimuli ascorbate/FeSO ₄ and H ₂ O ₂ /FeSO ₄ resulted in a significant generation of HNE, which is temporally...

article

Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding

Cinzia Domenicotti, Dimitri Paola, Antonella Vitali, Mariapaola Nitti, more

Free Radical Biology and Medicine > 2000 > 29 > 12 > 1280-1290

Treatment of isolated rat hepatocytes with the glutathione depleting agents L-buthionine-S,R-sulfoximine or diethylmaleate reproduced various cellular conditions of glutathione depletion, from moderate to severe, similar to those occurring in a wide spectrum of human liver diseases. To evaluate molecular changes and possible cellular dysfunction and damage consequent to a pathophysiologic level of...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Maria A. Pronzato

HO‐1 downregulation favors BRAF^V600 melanoma cell death induced by Vemurafenib/PLX4032 and increases NK recognition

Investigating the amyloid-beta enhancing effect of cGMP in neuro2a cells

HO-1 down-regulation increases the efficacy of BRAFV600E inhibition-based therapy in primary melanoma cells

Differentiation modifies Bach1 dependent regulation of HO-1 expression and increases sensitivity to oxidative stress in neuroblastoma cells

ATRA-induced neuronal differentiation reduces cell ability to adapt to oxidative stress: role of Nrf2 and HO-1

Amyloid β: Walking on the dark side of the moon

Monomeric Aβ1–42 and RAGE: key players in neuronal differentiation

Processing of the amyloid precursor protein: Role of protein kinase C and myosin IIB

Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma

PKC signaling in oxidative hepatic damage

Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-β deposition in N2a cells

In vitro effect of PPAR-γ2 Pro12Ala polymorphism on the deposition of Alzheimer's amyloid-β peptides

Vitamin E and neurodegenerative diseases

PKC delta and NADPH oxidase in AGE-induced neuronal death

Amyloid precursor protein processing: Role of peroxisome proliferator-activated receptor-gamma

Central role of PKCδ in glycoxidation-dependent apoptosis of human neurons

CD36 overexpression in human brain correlates with β-amyloid deposition but not with Alzheimer's disease

A novel role of protein kinase C-δ in cell signaling triggered by glutathione depletion

Oxidative Stress Increases Expression and Activity of BACE in NT ₂ Neurons

Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Maria A. Pronzato

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options