Search results for: Demetrios A. Spandidos

Items from 1 to 20 out of 121 results

article

Medical humility and greek mythology

Ioannis N Mammas, Demetrios A Spandidos

Journal of Paediatrics and Child Health > 55 > 8 > 999 - 999

article

Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer’s Disease Risk?

Polyxeni Stamati, Vasileios Siokas, Athina-Maria Aloizou, Emmanouil Karampinis, more

Journal of Molecular Neuroscience > 2019 > 69 > 2 > 343-350

Α number of genetic variants have been associated with Alzheimer’s disease (AD) susceptibility. Sec1 family domain-containing protein 1 (SCFD1) gene polymorphism rs10139154 has recently been implicated in the risk of developing amyotrophic lateral sclerosis (ALS). Similarities in the pathogenetic cascade of both diseases have also been described. The present study was designed to evaluate the possible...

article

Detection of carbapenemase producers by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)

Ioannis K. Neonakis, Demetrios A. Spandidos

European Journal of Clinical Microbiology & Infectious Diseases > 2019 > 38 > 10 > 1795-1801

Matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been recently applied in detection of carbapenemase-producing Gram-negative isolates. In the present study, we review the latest developments in this field.

article

Lack of Association of the rs11655081 ARSG Gene with Blepharospasm

Vasileios Siokas, Dimitrios Kardaras, Athina-Maria Aloizou, Ioannis Asproudis, more

Journal of Molecular Neuroscience > 2019 > 67 > 3 > 472-476

Blepharospasm (BSP) is a sub-phenotype of focal dystonia. A few genetic risk factors are considered to be implicated in the risk of developing BSP. There is recent evidence, based on results from GWAS and meta-analyses, to suggest that arylsulfatase G (ARSG), and more specifically rs11655081, is implicated in focal dystonia. The aim of the present study was to evaluate the effect of rs11655081 ARSG...

article

The 1918 Spanish flu outbreak that devastated a Greek island underlines past lessons that must never be forgotten

Ioannis N. Mammas, Maria Theodoridou, Demetrios A. Spandidos

Acta Paediatrica > 107 > 11 > 2034 - 2034

article

Contrast-induced nephropathy: Basic concepts, pathophysiological implications and prevention strategies

Charalampos Mamoulakis, Konstantinos Tsarouhas, Irini Fragkiadoulaki, Ioannis Heretis, more

Pharmacology & Therapeutics > 2017 > 180 > C > 99-112

Contrast-induced nephropathy (CIN) is reversible acute renal failure observed following administration of iodinated contrast media (CM) during angiographic or other medical procedures such as urography. There are various mechanisms through which CM develop their nephrotoxic effects, including oxidative stress and apoptosis. CIN is a real-life, albeit not very rare, entity. Exact pathophysiology remains...

article

Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells

Nicola E. Wilsher, Randolph R. Arroo, Minos–Timotheos Matsoukas, Aristidis M. Tsatsakis, more

Food and Chemical Toxicology > 2017 > 110 > C > 383-394

Natural flavonoids with methoxy substitutions are metabolized by CYP1 enzymes to yield the corresponding demethylated products. The present study aimed to characterize the metabolism and further antiproliferative activity of the hydroxylated flavonoids apigenin, luteolin, scutellarein, kaempferol and quercetin in CYP1 recombinant enzymes and in the CYP1 expressing cell lines MCF7 and MDA–MB–468, respectively...

article

Athens‐based meeting to discuss the paediatric virology crossroad in October 2017

Ioannis N. Mammas, Demetrios A. Spandidos

Acta Paediatrica > 106 > 9 > 1536 - 1536

article

Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

Stavros Sifakis, Vasilis P. Androutsopoulos, Aristeidis M. Tsatsakis, Demetrios A. Spandidos

Environmental Toxicology and Pharmacology > 2017 > 51 > C > 56-70

Endocrine disrupting chemicals (EDCs) comprise a group of chemical compounds that have been examined extensively due to the potential harmful effects in the health of human populations. During the past decades, particular focus has been given to the harmful effects of EDCs to the reproductive system. The estimation of human exposure to EDCs can be broadly categorized into occupational and environmental...

article

K-Ras, H-Ras, N-Ras and B-Raf mutation and expression analysis in Wilms tumors: association with tumor growth

Efterpi Dalpa, Victor Gourvas, Nikolaos Soulitzis, Demetrios A. Spandidos

Medical Oncology > 2017 > 34 > 1 > 1-10

Nephroblastoma (Wilms tumor) is a kidney neoplasia, predominately occurring at very young age, resulting from the malignant transformation of renal stem cells. The Ras proto-oncogenes and B-Raf are members of an intracellular cascade pathway, which regulates cell growth and differentiation, and ultimately cancer development. Our objective was to determine the mutation rate and to measure the mRNA...

article

Aberrant expression of miR-21, miR-376c miR-145 and their target host genes in Merkel cell polyomavirus-positive non-small cell lung cancer

Ismini Lasithiotaki, Eliza Tsitoura, Anastasios Koutsopoulos, Eleni Lagoudaki, more

Journal of Clinical Virology > 2016 > 82 > S > S138

article

Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma

Cristina A. Dehelean, Codruta Soica, Iulia Pinzaru, Dorina Coricovac, more

Food and Chemical Toxicology > 2016 > 95 > C > 149-158

The increased susceptibility of men as compared to women to develop different types of cancer, including skin cancer, is well known; however, the mechanisms involved in this process are still a matter of debate. This study aimed to obtain animal models of photo-chemically-induced skin carcinogenesis by exposure to ultraviolet radiation B (UVB) coupled with topical applications of a tumor initiator...

article

Vaccination against Human Papillomavirus in relation to Financial Crisis: The “Evaluation and Education of Greek Female Adolescents on Human Papillomaviruses’ Prevention Strategies” ELEFTHERIA Study

Ioannis N. Mammas, Maria Theodoridou, Chryssie Koutsaftiki, George Bertsias, more

Journal of Pediatric and Adolescent Gynecology > 2016 > 29 > 4 > 362-366

In this study we aimed to explore financial and other sociodemographic factors that affect nonvaccination against the human papillomavirus (HPV) in Greece, one of the first European Union countries to introduce the vaccination against HPV into its National Immunization Programme in 2008.Six hundred thirty-two female adolescents (aged 11-16 years) from Greece completed a pilot cross-sectional questionnaire-based...

article

An instructive viewpoint from the Greek mythology

Ioannis N Mammas, Demetrios A Spandidos

Journal of Paediatrics and Child Health > 51 > 2 > 172 - 173

article

Merkel cell polyomavirus infection in childhood: current advances and perspectives

George Sourvinos, Ioannis N. Mammas, Demetrios A. Spandidos

Archives of Virology > 2015 > 160 > 4 > 887-892

Merkel cell polyomavirus (MCPyV) is a newly discovered human small, non-enveloped, double-stranded DNA virus, which was classified into the Polyomaviridae family. MCPyV is acquired in early childhood through close contact involving respiratory tract secretions and causes a widespread, previously unrecognised, asymptomatic infection in both immunocompetent children and adults. To...

article

Epithelial–mesenchymal transition-associated miRNAs in ovarian carcinoma, with highlight on the miR-200 family: Prognostic value and prospective role in ovarian cancer therapeutics

Maria Koutsaki, Demetrios A. Spandidos, Apostolos Zaravinos

Cancer Letters > 2014 > 351 > 2 > 173-181

MicroRNAs (miRNAs) are a family of short ribonucleic acids found to play a pivotal role in cancer pathogenesis. MiRNAs are crucial in cellular differentiation, growth, stress response, cell death and other fundamental cellular processes, and their involvement in ovarian cancer has been recently shown. They can repress the expression of important cancer-related genes and they can also function both...

article

Reduced ANXA5 mRNA and protein expression in pregnancies complicated by preeclampsia

Victor Gourvas, Nikolaos Soulitzis, Anastasia Konstantinidou, Efterpi Dalpa, more

Thrombosis Research > 2014 > 133 > 3 > 495-500

The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. The aim of this study was to investigate the expression of ANXA5 in pregnancies complicated by preeclampsia (PE).Placental tissue samples were...

article

Genetic diversity of the KCNE1 gene and susceptibility to postoperative atrial fibrillation

Konstantinos V. Voudris, Stavros Apostolakis, Panagiotis Karyofillis, Konstantinos Doukas, more

American Heart Journal > 2014 > 167 > 2 > 274-280.e1

The human KCNE1 protein forms the β-subunit of the IKs potassium channel and is important in the regulation of the atrial action potential duration. The purpose of this study was to investigate the association between the nonsynonymous 112G>A mutation of the KCNE1 gene and postcardiac surgery atrial fibrillation (AF).A cohort of patients scheduled for cardiac surgery was prospectively recruited...

article

Gene set enrichment analysis of the NF-κB/Snail/YY1/RKIP circuitry in multiple myeloma

Apostolos Zaravinos, Peggy Kanellou, George Ι. Lambrou, Demetrios A. Spandidos

Tumor Biology > 2014 > 35 > 5 > 4987-5005

The presence of a dysregulated NF-κB/Snail/YY1/RKIP loop was recently established in metastatic prostate cancer cells and non-Hodgkin’s lymphoma; however, its involvement in multiple myeloma (MM) has yet to be investigated. Aim of the study was to investigate the role of the NF-κB/Snail/YY1/RKIP circuitry in MM and how each gene is correlated with the remaining genes of the loop. Using gene set enrichment...

article

Detection of human papillomavirus (HPV) DNA prevalence and p53 codon 72 (Arg72Pro) polymorphism in prostate cancer in a Greek group of patients

Vasiliki Michopoulou, Stavros P. Derdas, Emmanouil Symvoulakis, Nikolaos Mourmouras, more

Tumor Biology > 2014 > 35 > 12 > 12765- 12773

Prostate cancer is the most common neoplasm found in males and the second most frequent cause of cancer-related mortality in males in Greece. Among other pathogens, the detection frequency of human papillomavirus (HPV) has been found to be significantly increased in tumor tissues among patients with sexually transmitted diseases (STDs), depending on the geographical distribution of each population...

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INFONA - science communication portal

Search results for: Demetrios A. Spandidos

Medical humility and greek mythology

Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer’s Disease Risk?

Detection of carbapenemase producers by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS)

Lack of Association of the rs11655081 ARSG Gene with Blepharospasm

The 1918 Spanish flu outbreak that devastated a Greek island underlines past lessons that must never be forgotten

Contrast-induced nephropathy: Basic concepts, pathophysiological implications and prevention strategies

Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells

Athens‐based meeting to discuss the paediatric virology crossroad in October 2017

Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems

K-Ras, H-Ras, N-Ras and B-Raf mutation and expression analysis in Wilms tumors: association with tumor growth

Aberrant expression of miR-21, miR-376c miR-145 and their target host genes in Merkel cell polyomavirus-positive non-small cell lung cancer

Sex differences and pathology status correlated to the toxicity of some common carcinogens in experimental skin carcinoma

Vaccination against Human Papillomavirus in relation to Financial Crisis: The “Evaluation and Education of Greek Female Adolescents on Human Papillomaviruses’ Prevention Strategies” ELEFTHERIA Study

An instructive viewpoint from the Greek mythology

Merkel cell polyomavirus infection in childhood: current advances and perspectives

Epithelial–mesenchymal transition-associated miRNAs in ovarian carcinoma, with highlight on the miR-200 family: Prognostic value and prospective role in ovarian cancer therapeutics

Reduced ANXA5 mRNA and protein expression in pregnancies complicated by preeclampsia

Genetic diversity of the KCNE1 gene and susceptibility to postoperative atrial fibrillation

Gene set enrichment analysis of the NF-κB/Snail/YY1/RKIP circuitry in multiple myeloma

Detection of human papillomavirus (HPV) DNA prevalence and p53 codon 72 (Arg72Pro) polymorphism in prostate cancer in a Greek group of patients

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