Search results for: Margaret E. Gnegy

Items from 1 to 20 out of 28 results

article

Correction to: The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats

Rachel D. Altshuler, Colleen A. Carpenter, Timothy J. Franke, Margaret E. Gnegy, more

Psychopharmacology > 2019 > 236 > 11 > 3243-3243

The middle initial of the author should be “A” instead of “C”. The correct presentation of the author name is Colleen A. Carpenter.

article

The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats

Rachel D. Altshuler, Colleen A. Carpenter, Timothy J. Franke, Margaret E. Gnegy, more

Psychopharmacology > 2019 > 236 > 11 > 3231-3242

Rationale Pathological amphetamine (AMPH) use is a serious public health concern with no pharmacological treatment options. Protein kinase Cβ (PKCβ) has been implicated in the mechanism of action of AMPH, such that inhibition of PKCβ attenuates AMPH-stimulated dopamine efflux in vivo. With this in mind, inhibition of PKCβ may be a viable therapeutic target for AMPH use disorder. Objective The purpose...

article

Tamoxifen and amphetamine abuse: Are there therapeutic possibilities?

Sarah Mikelman, Natalie Mardirossian, Margaret E. Gnegy

Journal of Chemical Neuroanatomy > 2017 > 83-84 > C > 50-58

Although best known as a selective estrogen receptor modulator (SERM), tamoxifen is a drug with a wide range of activities. Tamoxifen has demonstrated some efficacy has a therapeutic for bipolar mania and is believed to exert these effects through inhibition of protein kinase C (PKC). As the symptoms of amphetamine treatment in rodents are believed to mimic the symptoms of a manic episode, many of...

article

Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors

Sarah R. Mikelman, Bipasha Guptaroy, Margaret E. Gnegy

Journal of Neurochemistry > 141 > 1 > 31 - 36

As one of the primary mechanisms by which dopamine signaling is regulated, the dopamine transporter (DAT) is an attractive pharmacological target for the treatment of diseases based in dopaminergic dysfunction. In this work we demonstrate for the first time that the commonly prescribed breast cancer therapeutic tamoxifen and its major metabolites, 4‐hydroxytamoxifen and endoxifen, inhibit DAT function...

article

Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function

Bryan F. Singer, Bipasha Guptaroy, Curtis J. Austin, Isabella Wohl, more

European Journal of Neuroscience > 43 > 5 > 662 - 670

Cues (conditioned stimuli; CSs) associated with rewards can come to motivate behavior, but there is considerable individual variation in their ability to do so. For example, a lever‐CS that predicts food reward becomes attractive and wanted, and elicits reward‐seeking behavior, to a greater extent in some rats (‘sign‐trackers’; STs) than others (‘goal‐trackers’; GTs). Variation in dopamine (DA) neurotransmission...

article

Protein kinase C beta regulates the D2-Like dopamine autoreceptor

Kathryn D. Luderman, Rong Chen, Mark J. Ferris, Sara R. Jones, more

Neuropharmacology > 2015 > 89 > Complete > 335-341

The focus of this study was the regulation of the D ₂ -like dopamine autoreceptor (D ₂ autoreceptor) by protein kinase Cβ, a member of the protein kinase C (PKC) family. Together with the dopamine transporter, the D ₂ autoreceptor regulates the level of extracellular dopamine and thus dopaminergic signaling. PKC regulates neuronal signaling via several mechanisms, including...

article

Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism

Kelly E. Bosse, Emily M. Jutkiewicz, Kristin N. Schultz-Kuszak, Omar S. Mabrouk, more

Neuropharmacology > 2014 > 77 > Complete > 19-27

Glutamate is known to cause the release of dopamine through a Ca ²⁺ -sensitive mechanism that involves activation of NMDA ionotropic glutamate receptors. In the current study, we tested the hypothesis that the delta opioid agonist SNC80 acts indirectly, via the glutamatergic system, to enhance both amphetamine-stimulated dopamine efflux from striatal preparations and amphetamine-stimulated...

article

Amphetamine stimulates movement through thalamocortical glutamate release

Omar S. Mabrouk, Daniel Z. Semaan, Sarah Mikelman, Margaret E. Gnegy, more

Journal of Neurochemistry > 128 > 1 > 152 - 161

The ventrolateral thalamus (VL) is a primary relay point between the basal ganglia and the primary motor cortex (M1). Using dual probe microdialysis and locomotor behavior monitoring, we investigated the contribution of VL input into M1 during amphetamine (AMPH)‐stimulated monoamine release and hyperlocomotion in rats. Tetrodotoxin (10 μM) perfusion into the VL significantly lowered hyperactivity...

article

Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor‐activated trafficking of the dopamine transporter

Rong Chen, Conor P. Daining, Haiguo Sun, Rheaclare Fraser, more

Journal of Neurochemistry > 125 > 5 > 663 - 672

The strength and duration of extracellular dopamine concentrations are regulated by the presynaptic dopamine transporter (DAT) and dopamine D2 autoreceptors (D2autoRs). There is a functional interaction between these two proteins. Activation of D2autoRs increases DAT trafficking to the surface whereas disruption of this interaction compromises activities of both proteins and alters dopaminergic transmission...

article

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

Gina M. Leinninger, Darren M. Opland, Young-Hwan Jo, Miro Faouzi, more

Cell Metabolism > 2011 > 14 > 3 > 313-323

Leptin acts on leptin receptor (LepRb)-expressing neurons throughout the brain, but the roles for many populations of LepRb neurons in modulating energy balance and behavior remain unclear. We found that the majority of LepRb neurons in the lateral hypothalamic area (LHA) contain neurotensin (Nts). To investigate the physiologic role for leptin action via these LepRb ^Nts neurons, we generated...

article

The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of β2 subunit-containing nicotinic acetylcholine receptors and glutamate N-methyl-d-aspartate receptors

Myung N. Kim, Emily M. Jutkiewicz, Minjia Zhang, Margaret E. Gnegy

Neuropharmacology > 2011 > 60 > 7-8 > 1126-1134

Nicotine has been demonstrated to enhance the subsequent use of illicit drugs in animals and humans. We previously demonstrated in female, Holtzman rats that one low dose of nicotine will potentiate locomotor activity and dopamine (DA) efflux in response to a subsequent low dose of d-amphetamine (AMPH) given 1–4 h later. In the present study, we show this also occurs in male rats and characterize...

article

PKCβ co-localizes with the dopamine transporter in mesencephalic neurons

Heather A. O’Malley, Yanghae Park, Lori L. Isom, Margaret E. Gnegy

Neuroscience Letters > 2010 > 480 > 1 > 40-43

The dopamine transporter (DAT) is a critical regulator of dopaminergic neurotransmission. Research in both rat striatum and heterologous cells suggests that protein kinase C beta (PKCβ) is important for proper trafficking of DAT. However, a critical gap that is missing from the literature is the localization of PKCβ to mesencephalic dopaminergic neurons. In this study we examined the co-localization...

article

Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague‐Dawley rats

Maura L. Perry, Gina M. Leinninger, Rong Chen, Kathryn D. Luderman, more

Journal of Neurochemistry > 114 > 3 > 666 - 674

J. Neurochem. (2010) 114, 666–674. AbstractAdipocytes produce the hormone, leptin, in proportion to fat mass to signal the status of body energy stores to the central nervous system, thereby modulating food intake and energy homeostasis. In addition to controlling satiety, leptin suppresses the reward value of food, which is controlled by the mesolimbic dopamine (DA) system. Previous results from...

article

Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells

Cheryse A. Furman, Charles B. Lo, Stephanie Stokes, Jose A. Esteban, more

Neuroscience Letters > 2009 > 463 > 1 > 78-81

The dopamine transporter (DAT) is a crucial regulator of dopaminergic neurotransmission which undergoes constitutive and substrate-mediated trafficking to and from the membrane. Although, considerable research has been done to elucidate the regulation of substrate-stimulated DAT trafficking, less is known about which trafficking proteins are involved in constitutive DAT trafficking. Rab proteins are...

article

The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum

Kelly E. Bosse, Emily M. Jutkiewicz, Margaret E. Gnegy, John R. Traynor

Neuropharmacology > 2008 > 55 > 5 > 755-762

The highly selective delta opioid agonist, SNC80, elicits dopamine-related behaviors including locomotor stimulation and conditioned place-preference. In contrast, it has been reported that SNC80 fails to promote dopamine efflux from the striatum of freely moving rats. However, SNC80 does enhance behavioral responses to the stimulants, amphetamine and cocaine, suggesting an interaction between delta...

article

Nicotine and amphetamine acutely cross-potentiate their behavioral and neurochemical responses in female Holtzman rats

Emily M. Jutkiewicz, Danielle M. Nicolazzo, Myung N. Kim, Margaret E. Gnegy

Psychopharmacology > 2008 > 200 > 1 > 93-103

Rationale Psychostimulants are often used in close temporal proximity to nicotine and have been reported to enhance acutely nicotine’s desirability in humans. Objective To investigate the acute associations between amphetamine and nicotine, we examined the potentiative interactions between clinically relevant, low doses of these drugs on locomotor activity, and dopamine overflow in the rat. Materials...

article

C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SvHsd mice

Rong Chen, Minjia Zhang, Soo Park, Margaret E. Gnegy

Pharmacology, Biochemistry and Behavior > 2007 > 87 > 1 > 158-163

Inbred strains of mice have served as valuable models for studying genetic susceptibility to drug addiction, an alternative to genetically modified mouse models. This is the first study comparing amphetamine (AMPH) effects on locomotor stimulation and dopamine efflux between two inbred strains of mice C57BL/6J and 129S2/SvHsd, frequently used as background strains for production of genetically engineered...

article

Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation

L'Aurelle A. Johnson, Cheryse A. Furman, Minjia Zhang, Bipasha Guptaroy, more

Neuropharmacology > 2005 > 49 > 6 > 750-758

The dopamine transporter, DAT, is a primary regulator of dopamine (DA) signaling at the synapse. Persistent stimulation with the substrate amphetamine (AMPH) promotes DAT internalization. AMPH rapidly elicits DA efflux, yet its effect on DAT trafficking at short times is unknown. We examined the rapid effect of AMPH on DAT trafficking in rat striatal synaptosomes using biotinylation to label surface...

article

The effect of phosphorylation on amphetamine-mediated outward transport

Margaret E. Gnegy

European Journal of Pharmacology > 2003 > 479 > 1-3 > 83-91

Amphetamine elicits its locomotor-activating and drug-reinforcing effects by releasing the catecholamines dopamine and norepinephrine into the synapse. Amphetamine is a substrate of the plasmalemmal transporters for both dopamine and norepinephrine. As such, it binds to the transporters in conjunction with Na ⁺ and Cl ^- , facilitating a conformational change leading the transporter...

article

Cytochrome c translocation does not lead to caspase activation in maitotoxin-treated SH-SY5Y neuroblastoma cells

Kim M. McGinnis, Margaret E. Gnegy, Nicole Falk, Rathna Nath, more

Neurochemistry International > 2003 > 42 > 6 > 517-523

Cytosolic cytochrome c elevation has been associated with activation of caspase-3-like proteases. In this study, we demonstrate that treatment with the neurotoxin and potent calcium channel opener maitotoxin (MTX) induces cytochrome c release from the mitochondria that is not accompanied by caspase activation. Cytochrome c translocation in MTX-treated SH-SY5Y cells was readily apparent after 30min...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Margaret E. Gnegy

Correction to: The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats

The protein kinase Cβ-selective inhibitor, enzastaurin, attenuates amphetamine-stimulated locomotor activity and self-administration behaviors in rats

Tamoxifen and amphetamine abuse: Are there therapeutic possibilities?

Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors

Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function

Protein kinase C beta regulates the D2-Like dopamine autoreceptor

Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism

Amphetamine stimulates movement through thalamocortical glutamate release

Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor‐activated trafficking of the dopamine transporter

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance

The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of β2 subunit-containing nicotinic acetylcholine receptors and glutamate N-methyl-d-aspartate receptors

PKCβ co-localizes with the dopamine transporter in mesencephalic neurons

Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague‐Dawley rats

Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells

The selective delta opioid agonist SNC80 enhances amphetamine-mediated efflux of dopamine from rat striatum

Nicotine and amphetamine acutely cross-potentiate their behavioral and neurochemical responses in female Holtzman rats

C57BL/6J mice show greater amphetamine-induced locomotor activation and dopamine efflux in the striatum than 129S2/SvHsd mice

Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation

The effect of phosphorylation on amphetamine-mediated outward transport

Cytochrome c translocation does not lead to caspase activation in maitotoxin-treated SH-SY5Y neuroblastoma cells

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Margaret E. Gnegy

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options