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Activated astrocytes have been implicated in the deleterious cascade of events immediately following traumatic brain injury (TBI). In this study, primary astrocytes were activated by a well-characterized stretch injury model of TBI. Nitrite production, an outcome measure for activation in astrocytes, increased significantly after injury. Using the cell-penetrating peptide (CPP) TAT, delivery of a...
Therapeutic delivery into the brain parenchyma is difficult due to the presence of the blood-brain barrier (BBB). One potential solution is to use cell-penetrating peptides (CPPs). CPPs are short peptides made up of primarily positively charged amino acids that have the ability to transduce cell membranes and deliver cargoes to cells. It is unclear, however, whether CPPs can penetrate cell barriers,...
The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain for treatment of CNS disorders. To search for more convenient models in studying the transport across the BBB, we compared four in vitro models: endothelial monoculture (bEnd3 cell line), coculture of bEnd3 and astrocytes (coculture), coculture with collagen type I and IV mixture, and coculture with Matrigel. We also...
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