Search results for: Aljoscha Thomschewski

Items from 1 to 14 out of 14 results

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Sample sizes and statistical methods in interventional studies on individuals with spinal cord injury: A systematic review

Georg Zimmermann, Lisa‐Maria Bolter, Ronny Sluka, Yvonne Höller, more

Journal of Evidence‐Based Medicine > 12 > 3 > 200 - 208

Aim Prevalence and incidence of spinal cord injury (SCI) are low. However, sample sizes have not been systematically examined yet, although this might represent useful information for study planning and power considerations. Therefore, our objective was to determine the median sample size in clinical trials on SCI individuals. Moreover, within small‐sample size studies, statistical methods and awareness...

article

Diagnostic accuracy of functional magnetic resonance imaging, Wada test, magnetoencephalography, and functional transcranial Doppler sonography for memory and language outcome after epilepsy surgery: A systematic review

Elisabeth Schmid, Aljoscha Thomschewski, Alexandra Taylor, Georg Zimmermann, more

Epilepsia > 59 > 12 > 2305 - 2317

Objective The European Union–funded E‐PILEPSY project was launched to develop guidelines and recommendations for epilepsy surgery. In this systematic review, we aimed to assess the diagnostic accuracy of functional magnetic resonance imaging (fMRI), Wada test, magnetoencephalography (MEG), and functional transcranial Doppler sonography (fTCD) for memory and language decline after surgery. Methods...

article

Perampanel in patients with refractory and super‐refractory status epilepticus in a neurological intensive care unit: A single‐center audit of 30 patients

Alexandra Rohracher, Gudrun Kalss, Caroline Neuray, Julia Höfler, more

Epilepsia > 59 > S2 > 234 - 242

In refractory status epilepticus (SE), γ‐aminobutyric acidergic drugs become less effective and glutamate plays a major role in seizure perpetuation. Data on the efficacy of perampanel (PER) in treatment of refractory SE in humans are limited. Here, we present a single‐center case series of patients with refractory SE who received PER orally in an intensive care unit. We retrospectively analyzed treatment...

article

Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes

Thibault Verhoeven, Ana Coito, Gijs Plomp, Aljoscha Thomschewski, more

NeuroImage: Clinical > 2018 > 17 > C > 10-15

To diagnose and lateralise temporal lobe epilepsy (TLE) by building a classification system that uses directed functional connectivity patterns estimated during EEG periods without visible pathological activity.Resting-state high-density EEG recording data from 20 left TLE patients, 20 right TLE patients and 35 healthy controls was used. Epochs without interictal spikes were selected. The cortical...

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P362 Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes

Ana Coito, Thibault Verhoeven, Gijs Plomp, Aljoscha Thomschewski, more

Clinical Neurophysiology > 2017 > 128 > 9 > e295

To diagnose and lateralise Temporal Lobe Epilepsy (TLE) by building a classification system that uses directed functional connectivity patterns estimated during EEG periods without visible pathological activity.Resting-state high-density EEG recording data from 20 left TLE patients, 20 right TLE patients and 35 healthy controls was used. Epochs without interictal spikes were selected. The cortical...

article

Status epilepticus in the elderly—A retrospective study on 120 patients

Alexandra Rohracher, Doris P. Reiter, Francesco Brigo, Gudrun Kalss, more

Epilepsy Research > 2016 > 127 > C > 317-323

Status epilepticus (SE) is one of the most common neurological emergencies with a high incidence in the elderly. Major determinants of prognosis are patients’ age, duration of SE and underlying etiology. We aimed identifying differences in clinical presentation of SE, etiologies and outcome between patients (pts.) sixty years or older (≥60) and younger than sixty (<60) years (yrs).We retrospectively...

article

Altered directed functional connectivity in temporal lobe epilepsy in the absence of interictal spikes: A high density EEG study

Ana Coito, Melanie Genetti, Francesca Pittau, Giannina R. Iannotti, more

Epilepsia > 57 > 3 > 402 - 411

ObjectiveIn patients with epilepsy, seizure relapse and behavioral impairments can be observed despite the absence of interictal epileptiform discharges (IEDs). Therefore, the characterization of pathologic networks when IEDs are not present could have an important clinical value. Using Granger‐causal modeling, we investigated whether directed functional connectivity was altered in electroencephalography...

article

Noninvasive Spinal Cord Stimulation: Technical Aspects and Therapeutic Applications

Raffaele Nardone, Yvonne Höller, Alexandra Taylor, Aljoscha Thomschewski, more

Neuromodulation: Technology at the Neural Interface > 18 > 7 > 580 - 591

BackgroundElectrical and magnetic trans‐spinal stimulation can be used to increase the motor output of multiple spinal segments and modulate cortico‐spinal excitability. The application of direct current through the scalp as well as repetitive transcranial magnetic stimulation are known to influence brain excitability, and hence can also modulate other central nervous system structures, including...

article

The ILAE definition of drug resistant epilepsy and its clinical applicability compared with “older” established definitions

Alexandra Rohracher, Judith Dobesberger, Claudia A. Granbichler, Julia Höfler, more

Journal of Epileptology > 2015 > 23 > 1 > 39-44

<bold>Background.</bold> Early identification of potential epilepsy surgery candidates is essential to the treatment process.<bold>Aim.</bold> To evaluate the clinical applicability of the ILAE definition of drug resistant epilepsy and its potential in identifying surgical candidates earlier compared to three established “older” definitions of drug resistant epilepsy.<bold>Material...

article

Serotonergic transmission after spinal cord injury

Raffaele Nardone, Yvonne Höller, Aljoscha Thomschewski, Peter Höller, more

Journal of Neural Transmission > 2015 > 122 > 2 > 279-295

Changes in descending serotonergic innervation of spinal neural activity have been implicated in symptoms of paralysis, spasticity, sensory disturbances and pain following spinal cord injury (SCI). Serotonergic neurons possess an enhanced ability to regenerate or sprout after many types of injury, including SCI. Current research suggests that serotonine (5-HT) release within the ventral horn of the...

article

Connectivity biomarkers can differentiate patients with different levels of consciousness

Yvonne Höller, Aljoscha Thomschewski, Jürgen Bergmann, Martin Kronbichler, more

Clinical Neurophysiology > 2014 > 125 > 8 > 1545-1555

In the present study, we searched for resting-EEG biomarkers that distinguish different levels of consciousness on a single subject level with an accuracy that is significantly above chance.We assessed 44 biomarkers extracted from the resting EEG with respect to their discriminative value between groups of minimally conscious (MCS, N=22) patients, vegetative state patients (VS, N=27), and – for a...

article

The role of the ipsilateral primary motor cortex in movement control after spinal cord injury: A TMS study

Raffaele Nardone, Yvonne Höller, Peter Höller, Natasha Thon, more

Neuroscience Letters > 2013 > 552 > Complete > 21-24

Previous neuroimaging studies raised the hypothesis that enhanced activity in the ipsilateral motor cortex (M1) plays a contributing role in the compensation for the motor deficits resulting from a spinal cord injury (SCI). However, it is still unknown whether the activity in the ipsilateral M1 directly contributes to movement performance after SCI. To address this question, we evaluated in five subjects...

article

Real movement vs. motor imagery in healthy subjects

Yvonne Höller, Jürgen Bergmann, Martin Kronbichler, Julia Sophia Crone, more

International Journal of Psychophysiology > 2013 > 87 > 1 > 35-41

Motor imagery tasks are well established procedures in brain computer interfaces, but are also used in the assessment of patients with disorders of consciousness. For testing awareness in unresponsive patients it is necessary to know the natural variance of brain responses to motor imagery in healthy subjects.We examined 22 healthy subjects using EEG in three conditions: movement of both hands, imagery...

article

Individual brain-frequency responses to self-selected music

Yvonne Höller, Aljoscha Thomschewski, Elisabeth Verena Schmid, Peter Höller, more

International Journal of Psychophysiology > 2012 > 86 > 3 > 206-213

Music is a stimulus which may give rise to a wide range of emotional and cognitive responses. Therefore, brain reactivity to music has become a focus of interest in cognitive neuroscience. It is possible that individual preference moderates the effectof music on the brain.In the present study we examined whether there are common effects of listening to music even if each subject in a sample chooses...

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