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Metastasis to bone is a major complication of advanced cancer and occurs in more than 400,000 cancer patients each year. Bone metastasis can arise from many different tumor types, including breast, prostate, lung, renal cell, thyroid, and bladder cancer, and in patients with melanoma and myeloma. The development of bone metastasis in cancer patients contributes significantly to the morbidity and mortality...
A novel class of thymidine phosphorylase (TP) inhibitors has been designed based on analogy to the enzyme substrate as well as known inhibitors. Flexible docking studies, using a homology model of human TP, of the designed N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as well as their synthetic precursors provide insight into the observed experimental trends in binding affinity.
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.