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We prepared, by solution‐phase methods, and fully characterized three analogs of the membrane‐active peptaibiotic alamethicin F50/5, bearing a single trifluoroacetyl (Tfa) label at the N‐terminus, at position 9 (central region) or at position 19 (C‐terminus), and with the three Gln at positions 7, 18, and 19 replaced by Glu(OMe) residues. To add the Tfa label at position 9 or 19, a γ‐trifluoroacetylated...
Integramide A is a 16‐amino acid peptide inhibitor of the enzyme HIV‐1 integrase. We have recently reported that the absolute stereochemistries of the dipeptide sequence near the C terminus are L‐Iva14‐D‐Iva15. Herein, we describe the syntheses of the natural compound and its D‐Iva14‐L‐Iva15 diastereomer, and the results of their chromatographic/mass spectrometric analyses. We present the conformational...
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