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Prostaglandin (PG) E 2 , a major product of activated macrophages, has been implicated in atherosclerosis and plaque rupture. The PGE 2 receptors, EP2 and EP4, are expressed in atherosclerotic lesions and are known to inhibit apoptosis in cancer cells. To examine the roles of macrophage EP4 and EP2 in apoptosis and early atherosclerosis, fetal liver cell transplantation was used to...
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