Search results for: Ben de Kruijff

Items from 1 to 20 out of 113 results

article

Reproduction of Vesicles upon Fatty Acid Addition

Nicole A. Pfleger, Albert J. Markvoort, Ben de Kruijff, Rutger A. van Santen, more

Biophysical Journal > 2011 > 100 > 3 Supplement 1 > 330a

article

Self-Reproduction of Fatty Acid Vesicles: A Combined Experimental and Simulation Study

Albert J. Markvoort, Nicole Pfleger, Rutger Staffhorst, Peter A.J. Hilbers, more

Biophysical Journal > 2010 > 99 > 5 > 1520-1528

Dilution of a fatty acid micellar solution at basic pH toward neutrality results in spontaneous formation of vesicles with a broad size distribution. However, when vesicles of a defined size are present before dilution, the size distribution of the newly formed vesicles is strongly biased toward that of the seed vesicles. This so-called matrix effect is believed to be a key feature of early life....

article

Reproduction of Fatty Acid Vesicles

Nicole Pfleger, Albert J. Markvoort, Rutger Staffhorst, Rutger A. van Santen, more

Biophysical Journal > 2010 > 98 > 3 Supplement 1 > 272a

article

A Systematic Approach Towards Elucidation of the Mode of Action of a Bacterial Thermosensor

Larisa E. Cybulski, Joost Ballering, Jacques P.F. Doux, Martijn C. Koorengevel, more

Biophysical Journal > 2010 > 98 > 3 Supplement 1 > 88a

article

Impaired Processing of Human Pro-Islet Amyloid Polypeptide Is Not a Causative Factor for Fibril Formation or Membrane Damage in Vitro

Lucie Khemtémourian, Gemma Lahoz Casarramona, Dennis P. L. Suylen, Tilman M. Hackeng, more

Biochemistry > 2009 > 48 > 46 > 10918 - 10925

article

Potential scorpionate antibiotics: Targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

H. Bauke Albada, Christopher J. Arnusch, Hilbert M. Branderhorst, Anne-Marie Verel, more

Bioorganic & Medicinal Chemistry Letters > 2009 > 19 > 14 > 3721-3724

The antibiotic vancomycin—that binds lipid II in the bacterial cell membrane—was conjugated to a mono- and tetravalent mimic of the tris-histidine catalytic triad of metalloenzymes. Targeted hydrolysis by the conjugate was observed using model membranes containing lipid II, and in vitro MIC-values of the targeted mimic constructs could be modulated by Zn-ions.

article

Photocrosslinking and Click Chemistry Enable the Specific Detection of Proteins Interacting with Phospholipids at the Membrane Interface

Jacob Gubbens, Eelco Ruijter, Laurence E.V. de Fays, J. Mirjam A. Damen, more

Chemistry & Biology > 2009 > 16 > 1 > 3-14

New lipid analogs mimicking the abundant membrane phospholipid phosphatidylcholine were developed to photocrosslink proteins interacting with phospholipid headgroups at the membrane interface. In addition to either a phenylazide or benzophenone photoactivatable moiety attached to the headgroup, the lipid analogs contained azides attached as baits to the acyl chains. After photocrosslinking in situ...

article

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci ^†

Christopher J. Arnusch, Alexandre M. J. J. Bonvin, Anne Marie Verel, Wouter T. M. Jansen, more

Biochemistry > 2008 > 47 > 48 > 12661 - 12663

article

Protein complexes in bacterial and yeast mitochondrial membranes differ in their sensitivity towards dissociation by SDS

Jacob Gubbens, Monique Slijper, Ben de Kruijff, Anton I.P.M. de Kroon

BBA - Proteins and Proteomics > 2008 > 1784 > 12 > 2012-2018

Previously, a 2D gel electrophoresis approach was developed for the Escherichia coli inner membrane, which detects membrane protein complexes that are stable in sodium dodecyl sulfate (SDS) at room temperature, and dissociate under the influence of trifluoroethanol [R. E. Spelbrink et al., J. Biol. Chem. 280 (2005), 28742-8]. Here, the method was applied to the evolutionarily related mitochondrial...

article

Lipid II: A central component in bacterial cell wall synthesis and a target for antibiotics

Ben de Kruijff, Vincent van Dam, Eefjan Breukink

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) > 2008 > 79 > 3-5 > 117-121

The bacterial cell wall is mainly composed of peptidoglycan, which is a three-dimensional network of long aminosugar strands located on the exterior of the cytoplasmic membrane. These strands consist of alternating MurNAc and GlcNAc units and are interlinked to each other via peptide moieties that are attached to the MurNAc residues. Peptidoglycan subunits are assembled on the cytoplasmic side of...

article

Membrane Organization and Ionization Behavior of the Minor but Crucial Lipid Ceramide-1-Phosphate

Edgar E. Kooijman, Jesús Sot, L.-Ruth Montes, Alicia Alonso, more

Biophysical Journal > 2008 > 94 > 11 > 4320-4330

Ceramide-1-phosphate (Cer-1-P), one of the simplest of all sphingophospholipids, occurs in minor amounts in biological membranes. Yet recent evidence suggests important roles of this lipid as a novel second messenger with crucial tasks in cell survival and inflammatory responses. We present a detailed description of the physical chemistry of this hitherto little explored membrane lipid. At full hydration...

article

Protein Self-Assembly and Lipid Binding in the Folding of the Potassium Channel KcsA ^†

Francisco N. Barrera, M. Lourdes Renart, José A. Poveda, Ben de Kruijff, more

Biochemistry > 2008 > 47 > 7 > 2123 - 2133

article

Phosphatidic acid plays a special role in stabilizing and folding of the tetrameric potassium channel KcsA

Mobeen Raja, Robin E.J. Spelbrink, Ben de Kruijff, J. Antoinette Killian

FEBS Letters > 2007 > 581 > 29 > 5715-5722

In this study, we investigated how the presence of anionic lipids influenced the stability and folding properties of the potassium channel KcsA. By using a combination of gel electrophoresis, tryptophan fluorescence and acrylamide quenching experiments, we found that the presence of the anionic lipid phosphatidylglycerol (PG) in a phosphatidylcholine (PC) bilayer slightly stabilized the tetramer and...

article

Enhanced Membrane Pore Formation by Multimeric/Oligomeric Antimicrobial Peptides ^†

Christopher J. Arnusch, Hilbert Branderhorst, Ben de Kruijff, Rob M. J. Liskamp, more

Biochemistry > 2007 > 46 > 46 > 13437 - 13442

article

Probing the Membrane Interface-Interacting Proteome Using Photoactivatable Lipid Cross-Linkers

Jacob Gubbens, Pieter Vader, J. Mirjam A. Damen, Martina C. O'Flaherty, more

Journal of Proteome Research > 2007 > 6 > 5 > 1951 - 1962

article

2,2,2-Trifluoroethanol Changes the Transition Kinetics and Subunit Interactions in the Small Bacterial Mechanosensitive Channel MscS

Bradley Akitake, Robin E.J. Spelbrink, Andriy Anishkin, J. Antoinette Killian, more

Biophysical Journal > 2007 > 92 > 8 > 2771-2784

2,2,2-Trifluoroethanol (TFE), a low-dielectric solvent, has recently been used as a promising tool to probe the strength of intersubunit interactions in membrane proteins. An analysis of inner membrane proteins of Escherichia coli has identified several SDS-resistant protein complexes that separate into subunits upon exposure to TFE. One of these was the homo-heptameric stretch-activated mechanosensitive...

article

Islet Amyloid Polypeptide Inserts into Phospholipid Monolayers as Monomer

Maarten F.M. Engel, HaciAli Yigittop, Ronald C. Elgersma, Dirk T.S. Rijkers, more

Journal of Molecular Biology > 2006 > 356 > 3 > 783-789

Amyloid deposits in the pancreatic islets of Langerhans are thought to be a main factor responsible for death of the insulin-producing islet β-cells in type 2 diabetes. It is hypothesized that β-cell death is related to interaction of the 37 amino acid residue human islet amyloid polypeptide (hIAPP), the major constituent of islet amyloid, with cellular membranes. However, the mechanism of hIAPP–membrane...

article

What Makes the Bioactive Lipids Phosphatidic Acid and Lysophosphatidic Acid So Special? ^†

Edgar E. Kooijman, Karen M. Carter, Emma G. van Laar, Vladimir Chupin, more

Biochemistry > 2005 > 44 > 51 > 17007 - 17015

article

A Synergistic Effect between Cholesterol and Tryptophan-Flanked Transmembrane Helices Modulates Membrane Curvature ^†

Bianca Y. van Duyl, Hans Meeldijk, Arie J. Verkleij, Dirk T. S. Rijkers, more

Biochemistry > 2005 > 44 > 11 > 4526 - 4532

article

Spontaneous Curvature of Phosphatidic Acid and Lysophosphatidic Acid ^†

Edgar E. Kooijman, Vladimir Chupin, Nola L. Fuller, Michael M. Kozlov, more

Biochemistry > 2005 > 44 > 6 > 2097 - 2102

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CHLOROPLAST PROTEIN IMPORT (5)
MODEL MEMBRANE (5)
PHOSPHATIDYLETHANOLAMINE (5)
PHOSPHOLIPID (5)
TRANSIT PEPTIDE (5)
ANIONIC PHOSPHOLIPID (4)
CARDIOLIPIN (4)
PROTEIN TRANSLOCATION (4)
PROTEIN-LIPID INTERACTION (4)
ANTIBIOTIC (3)
BACTERIAL MEMBRANE (3)
CHOLESTEROL (3)
CISPLATIN (3)
DOXORUBICIN (3)
ESCHERICHIA COLI (3)
LEADER PEPTIDASE (3)
LIPID BILAYER (3)
LIPID-PROTEIN INTERACTION (3)
MEMBRANE (3)
MEMBRANE POTENTIAL (3)
MEMBRANE PROTEIN (3)
OLIGOMERIZATION (3)
RAFT (3)
SECA (3)
SPHINGOLIPID (3)
AMYLIN (2)
AMYLOID (2)
BILAYER PERMEABILITY (2)
CHAPERONE (2)
CHLOROPLAST (2)
CONFORMATIONAL FLEXIBILITY (2)
DRUG-MEMBRANE INTERACTION (2)
ELECTROSPRAY IONIZATION MASS SPECTROMETRY (2)
ENDOPLASMIC RETICULUM (2)
GLYCOALKALOID (2)
LARGE UNILAMELLAR VESICLE (2)
LIPID II (2)
LIPID POLYMORPHISM (2)
LIPID TRANSPORT (2)
MEMBRANE INSERTION (2)
MICROSOME (2)
MITOCHONDRIAL PRESEQUENCE (2)
MITOCHONDRION (2)
PEPTIDE (2)
PHASE SEPARATION (2)
PHOSPHATIDYLCHOLINE (2)
PHOSPHATIDYLSERINE (2)
PORE SIZE (2)
POTASSIUM CHANNEL (2)
PROTEIN SECRETION (2)
SECB (2)
STABILITY (2)
VESICLE (2)
YEAST (2)
3 1 P NMR (1)
3 1 P-NMR (1)
ETHYLENE GLYCOL MEMBRANE DISORDERING DEHYDRATION 2 H NMR DIOLEOYLPHOSPHATIDYLCHOLINE DIOLEOYLPHOSPHATIDIC ACID (1)
HEXAGONAL H I I PHASE (1)
PHOSPHOLIPASE A 2 (1)
(E. COLI) (1)
(RAT LIVER) (1)
2D GEL ELECTROPHORESIS (1)
2D NMR (1)
2H NMR (1)
2H NUCLEAR MAGNETIC RESONANCE (1)
ACETYLATION (1)
ACTIVATION ENERGY (1)
AMPHIPHILIC Α HELIX (1)
ANIONIC LIPID (1)
ANTI-CANCER DRUG (1)
APOCYTOCHROME C (1)
ASSEMBLY (1)
ATOMIC FORCE MICROSCOPY (1)
BACTOPRENYL-PHOSPHATE (1)
BILAYER (1)
BIOMEMBRANE (1)
C6-NBD-PHOSPHOLIPID (1)
CACO-2 (1)
CANCER (1)
CHEMBIO (1)
CIRCULAR DICHROISM (1)
CIS-DIAMMINEDICHLOROPLATINUM(II) (1)
CLICK CHEMISTRY (1)
CROSSLINKING (1)
CRYSTAL STRUCTURE (1)
CRYSTALLIZATION (1)
CURVATURE (1)
CYTOSOLIC LEAFLET (1)
DENDRIMER (1)
DEUTERIUM NUCLEAR MAGNETIC RESONANCE (1)
DIACYLGLYCEROL (1)
DIELAIDOYLPHOSPHATIDYLETHANOLAMINE (1)
DIFFUSION (1)
DIMYRISTOYLPHOSPHATIDYLCHOLINE (1)
DIOLEOYLPHOSPHATIDYLCHOLINE (1)
DITHIONITE (1)
DROUGHT TOLERANCE (1)
DRUG DELIVERY (1)
DRUG STACKING (1)
ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY (1)
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Elsevier (83)
ACS (30)

Journal

FEBS Letters (37)
Biochemistry (28)
BBA - Biomembranes (15)
Biophysical Journal (13)
Journal of Structural Biology (2)
Progress in Biophysics and Molecular Biology (2)
Analytical Biochemistry (1)
BBA - Molecular Cell Research (1)
BBA - Molecular and Cell Biology of Lipids (1)
BBA - Proteins and Proteomics (1)
Biochimica et Biophysica Acta (BBA)/Reviews on Biomembranes (1)
Biochimica et Biophysica Acta (BBA) - Biomembranes (1)
Bioorganic & Medicinal Chemistry Letters (1)
Chemistry & Biology (1)
Current Opinion in Chemical Biology (1)
FEMS Microbiology Letters (1)
Journal of Molecular Biology (1)
Journal of Proteome Research (1)
Journal of the American Chemical Society (1)
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) (1)
Protein Expression and Purification (1)
Seminars in Cell and Developmental Biology (1)
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INFONA - science communication portal

Search results for: Ben de Kruijff

Reproduction of Vesicles upon Fatty Acid Addition

Self-Reproduction of Fatty Acid Vesicles: A Combined Experimental and Simulation Study

Reproduction of Fatty Acid Vesicles

A Systematic Approach Towards Elucidation of the Mode of Action of a Bacterial Thermosensor

Impaired Processing of Human Pro-Islet Amyloid Polypeptide Is Not a Causative Factor for Fibril Formation or Membrane Damage in Vitro

Potential scorpionate antibiotics: Targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions

Photocrosslinking and Click Chemistry Enable the Specific Detection of Proteins Interacting with Phospholipids at the Membrane Interface

The Vancomycin−Nisin(1−12) Hybrid Restores Activity against Vancomycin Resistant Enterococci ^†

Protein complexes in bacterial and yeast mitochondrial membranes differ in their sensitivity towards dissociation by SDS

Lipid II: A central component in bacterial cell wall synthesis and a target for antibiotics

Membrane Organization and Ionization Behavior of the Minor but Crucial Lipid Ceramide-1-Phosphate

Protein Self-Assembly and Lipid Binding in the Folding of the Potassium Channel KcsA ^†

Phosphatidic acid plays a special role in stabilizing and folding of the tetrameric potassium channel KcsA

Enhanced Membrane Pore Formation by Multimeric/Oligomeric Antimicrobial Peptides ^†

Probing the Membrane Interface-Interacting Proteome Using Photoactivatable Lipid Cross-Linkers

2,2,2-Trifluoroethanol Changes the Transition Kinetics and Subunit Interactions in the Small Bacterial Mechanosensitive Channel MscS

Islet Amyloid Polypeptide Inserts into Phospholipid Monolayers as Monomer

What Makes the Bioactive Lipids Phosphatidic Acid and Lysophosphatidic Acid So Special? ^†

A Synergistic Effect between Cholesterol and Tryptophan-Flanked Transmembrane Helices Modulates Membrane Curvature ^†

Spontaneous Curvature of Phosphatidic Acid and Lysophosphatidic Acid ^†

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