Search results for: George L. McLendon

Items from 1 to 19 out of 19 results

article

Biochemical Basis for Enhanced Binding of Peptide Dimers to X-Linked Inhibitor of Apoptosis Protein ^†

Kathryn E. Splan, John E. Allen, George L. McLendon

Biochemistry > 2007 > 46 > 42 > 11938 - 11944

article

Structure–activity based study of the Smac-binding pocket within the BIR3 domain of XIAP

Aislyn D. Wist, Lichuan Gu, Stefan J. Riedl, Yigong Shi, more

Bioorganic & Medicinal Chemistry > 2007 > 15 > 8 > 2935-2943

A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP...

article

Tryptophan and tyrosine to terbium fluorescence resonance energy transfer as a method to “map” aromatic residues and monitor docking

John E. Allen, George L. McLendon

Biochemical and Biophysical Research Communications > 2006 > 349 > 4 > 1264-1268

Fluorescent lanthanide ions, with large Stokes shifts and narrow emission bands, are excellent tools for the development of FRET-based assays. In this work, a terbium ion is tethered to a peptide which binds to the BIR3 domain of XIAP, an anti-apoptotic protein. Excitation of tryptophan and tyrosine residues in the BIR3 domain causes the peptide bound terbium ion to fluoresce relative to its distance...

article

Endonuclease-like activity of heme proteins

Willy B. Tan, Wunhuey Cheng, Andrew Webber, Akhilesh Bhambhani, more

JBIC Journal of Biological Inorganic Chemistry > 2005 > 10 > 7 > 790-799

Heme proteins, metmyoglobin, methemoglobin, and metcytochrome c showed unusual affinity for double-stranded DNA. Calorimetric studies show that binding of methemoglobin to calf thymus DNA (CTDNA) is weakly endothermic, and the binding constant is 4.9±0.7×10⁵ M⁻¹. The Soret absorption bands of the heme proteins remained unchanged, in the presence of excess CTDNA, but a new circular dichroic band appeared...

article

Design, Folding, and Activities of Metal-Assembled Coiled Coil Proteins

Allison J. Doerr, George L. McLendon

Inorganic Chemistry > 2004 > 43 > 25 > 7916 - 7925

article

Metal-Assembled Modular Proteins: Toward Functional Protein Design

Martin A. Case, George L. McLendon

Accounts of Chemical Research > 2004 > 37 > 10 > 754 - 762

article

Hemoglobin Site-mutants Reveal Dynamical Role of Interhelical H-bonds in the Allosteric Pathway: Time-resolved UV Resonance Raman Evidence for Intra-dimer Coupling

Gurusamy Balakrishnan, Ching-Hsuan Tsai, Qiang Wu, Martin A Case, more

Journal of Molecular Biology > 2004 > 340 > 4 > 857-868

The dynamical effect of eliminating specific tertiary H-bonds in the hemoglobin (Hb) tetramer has been investigated by site-directed mutagenesis and time-resolved absorption and ultraviolet resonance Raman (UVRR) spectroscopy. The Trpα14⋯Thrα67 and Trpβ15⋯Serβ72 H-bonds connect the A and E helices in the α and β chains, and are proposed to break in the earliest protein intermediate (R_deoxy) following...

article

Time-resolved Absorption and UV Resonance Raman Spectra Reveal Stepwise Formation of T Quaternary Contacts in the Allosteric Pathway of Hemoglobin

Gurusamy Balakrishnan, Martin A Case, Alex Pevsner, Xiaojie Zhao, more

Journal of Molecular Biology > 2004 > 340 > 4 > 843-856

Hemoglobin undergoes a series of molecular changes on the nanosecond and microsecond time-scale following photodissociation of CO ligands. We have monitored these processes with a combination of transient absorption and resonance Raman (RR) spectroscopy. The latter have been acquired at higher data rates than previously available, thanks to kilohertz Ti:sapphire laser technology, with frequency-quadrupling...

article

Design of a Functional Protein for Molecular Recognition: Specificity of Ligand Binding in a Metal-Assembled Protein Cavity Probed by ¹⁹ F NMR

Allison J. Doerr, Martin A. Case, István Pelczer, George L. McLendon

Journal of the American Chemical Society > 2004 > 126 > 13 > 4192 - 4198

article

A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay

Constance J. Glover, Karen Hite, Renee DeLosh, Dominic A. Scudiero, more

Analytical Biochemistry > 2003 > 320 > 2 > 157-169

Resistance to apoptosis is afforded by inhibitor of apoptosis proteins (IAPs) which bind to and inhibit the caspases responsible for cleavage of substrates leading to apoptotic cell death. Smac (or DIABLO), a proapoptotic protein released from the mitochondrial intermembrane space into the cytosol, promotes apoptosis by binding to IAPs, thus reversing their inhibitory effects on caspases. We have...

article

Effect of redox potential of the heme on the peroxidase activity of cytochrome b562

Shyamalava Mazumdar, Stacy L. Springs, George L. McLendon

Biophysical Chemistry > 2003 > 105 > 2-3 > 263-268

Measurements of peroxidase activities of two site-specific mutants and wild type cytochrome b562 suggest that the enzymatic activity correlates with the redox potential of the metal center. A lower value of the Fe ³ ⁺ /Fe ² ⁺ redox potential seems to be important for promoting peroxidase activity of the hemeprotein possibly by stabilization of the high-valent redox intermediate...

article

Cytochrome c and the suicide hotline

George L. McLendon

Journal of Inorganic Biochemistry > 2003 > 96 > 1 > 32

article

Do Main Chain Hydrogen Bonds Create Dominant Electron Transfer Pathways? An Investigation in Designed Proteins ^†

Yongjian Zheng, Martin A. Case, James F. Wishart, George L. McLendon

The Journal of Physical Chemistry B > 2003 > 107 > 30 > 7288 - 7292

article

Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometric Analysis of Metal-Ion Selected Dynamic Protein Libraries

Helen J. Cooper, Martin A. Case, George L. McLendon, Alan G. Marshall

Journal of the American Chemical Society > 2003 > 125 > 18 > 5331 - 5339

article

Using Nanografting to Achieve Directed Assembly of de novo Designed Metalloproteins on Gold

Martin A. Case, George L. McLendon, Ying Hu, T. Kyle Vanderlick, more

Nano Letters > 2003 > 3 > 4 > 425 - 429

article

Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners ^†

Rachael A. Kipp, Martin A. Case, Aislyn D. Wist, Catherine M. Cresson, more

Biochemistry > 2002 > 41 > 23 > 7344 - 7349

article

A Multigeneration Analysis of Cytochrome b ₅₆₂ Redox Variants: Evolutionary Strategies for Modulating Redox Potential Revealed Using a Library Approach ^†

Stacy L. Springs, Susanna E. Bass, Greg Bowman, Ilana Nodelman, more

Biochemistry > 2002 > 41 > 13 > 4321 - 4328

article

Carbon Monoxide Binding by de Novo Heme Proteins Derived from Designed Combinatorial Libraries

David A. Moffet, Martin A. Case, John C. House, Kathleen Vogel, more

Journal of the American Chemical Society > 2001 > 123 > 10 > 2109 - 2115

article

Optical properties of nanocrystalline silver halides

Michal Ilana Freedhoff, Alfred P. Marchetti, George L. McLendon

Journal of Luminescence > 1996 > 70 > 1-6 > 400-413

A review of quantum confinement effects in nanocrystals of silver bromide (AgBr) and silver iodide (AgI) is presented. AgBr is an indirect gap semiconductor while AgI has a direct band-to-band lowest energy transition. An examination of the low-temperature optical properties of quantum confined AgBr grown using a variety of synthetic techniques will be made. The dynamics of some of the involved excitonic...

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