Search results for: Glenn L. Millhauser

Items from 1 to 20 out of 46 results

article

Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin‐4 receptor

Erica J. P. Anderson, Masoud Ghamari‐Langroudi, Isin Cakir, Michael J. Litt, more

Journal of Neuroendocrinology > 31 > 1 > n/a - n/a

Energy stores in fat tissue are determined in part by the activity of hypothalamic neurones expressing the melanocortin‐4 receptor (MC4R). Even a partial reduction in MC4R expression levels in mice, rats or humans produces hyperphagia and morbid obesity. Thus, it is of great interest to understand the molecular basis of neuromodulation by the MC4R. The MC4R is a G protein‐coupled receptor that signals...

article

Impacts of oxygen vacancies on the electrocatalytic activity of AuTiO2 nanocomposites towards oxygen reduction

Samantha W. Sweeney, Graham Roseman, Christopher P. Deming, Nan Wang, more

International Journal of Hydrogen Energy > 2016 > 41 > 40 > 18005- 18014

Nanocomposites based on metal nanoparticles supported on oxide surfaces have been used extensively as effective catalysts for fuel cell electrochemistry. In this study, functional nanocomposites based on gold nanoparticles deposited onto TiO₂ colloids were prepared by a simple wet chemistry method, and subject to hydrothermal treatment at a controlled temperature in the presence of ascorbic acid....

article

Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation

Eric G.B. Evans, M. Jake Pushie, Kate A. Markham, Hsiau-Wei Lee, more

Structure > 2016 > 24 > 7 > 1057-1067

Copper plays a critical role in prion protein (PrP) physiology. Cu²⁺ binds with high affinity to the PrP N-terminal octarepeat (OR) domain, and intracellular copper promotes PrP expression. The molecular details of copper coordination within the OR are now well characterized. Here we examine how Cu²⁺ influences the interaction between the PrP N-terminal domain and the C-terminal globular domain. Using...

article

Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System

Matthew A. Nix, Christopher B. Kaelin, Rafael Palomino, Jillian L. Miller, more

Biophysical Journal > 2015 > 109 > 9 > 1946-1958

The β-defensins are a class of small cationic proteins that serve as components of numerous systems in vertebrate biology, including the immune and melanocortin systems. Human β-defensin 3 (HBD3), which is produced in the skin, has been found to bind to melanocortin receptors 1 and 4 through complementary electrostatics, a unique mechanism of ligand-receptor interaction. This finding indicates that...

article

n‐Dopants Based on Dimers of Benzimidazoline Radicals: Structures and Mechanism of Redox Reactions

Siyuan Zhang, Benjamin D. Naab, Evgheni V. Jucov, Sean Parkin, more

Chemistry – A European Journal > 21 > 30 > 10878 - 10885

Dimers of 2‐substituted N,N′‐dimethylbenzimidazoline radicals, (2‐Y‐DMBI)₂ (Y=cyclohexyl (Cyc), ferrocenyl (Fc), ruthenocenyl (Rc)), have recently been reported as n‐dopants for organic semiconductors. Here their structural and energetic characteristics are reported, along with the mechanisms by which they react with acceptors, A (PCBM, TIPS‐pentacene), in solution. X‐ray data and DFT calculations...

article

Tyrosine nitration in peptides by peroxynitrite generated in situ in a light-controlled platform: Effects of pH and thiols

Tara R. deBoer, Rafael I. Palomino, Sharon O. Idiga, Glenn L. Millhauser, more

Journal of Inorganic Biochemistry > 2014 > 138 > C > 24-30

Peroxynitrite has been shown to play a critical role in inflammation and affords 3-nitrotyrosine as the hallmark product. The reported methods of generating this reactive nitrogen species in situ often fails to provide a high and steady flux of peroxynitrite resulting in poor yields of 3-nitrotyrosine. Herein we report a two-component peroxynitrite-generating platform in which this anion is produced...

article

Combined EXAFS and DFT Structure Calculations Provide Structural Insights into the 1:1 Multi‐Histidine Complexes of Cu^II, Cu^I, and Zn^II with the Tandem Octarepeats of the Mammalian Prion Protein

M. Jake Pushie, Kurt H. Nienaber, Alex McDonald, Glenn L. Millhauser, more

Chemistry – A European Journal > 20 > 31 > 9770 - 9783

The metal‐coordinating properties of the prion protein (PrP) have been the subject of intense focus and debate since the first reports of its interaction with copper just before the turn of the century. The picture of metal coordination to PrP has been improved and refined over the past decade, but structural details of the various metal coordination modes have not been fully elucidated in some cases...

article

Adapter reagents for protein site specific dye labeling

Darren A. Thompson, Eric G. B. Evans, Tomas Kasza, Glenn L. Millhauser, more

Biopolymers > 102 > 3 > 273 - 279

Chemoselective protein labeling remains a significant challenge in chemical biology. Although many selective labeling chemistries have been reported, the practicalities of matching the reaction with appropriately functionalized proteins and labeling reagents is often a challenge. For example, we encountered the challenge of site specifically labeling the cellular form of the murine Prion protein with...

article

Copper–zinc cross-modulation in prion protein binding

Francesco Stellato, Velia Minicozzi, Glenn L. Millhauser, Marco Pascucci, more

European Biophysics Journal > 2014 > 43 > 12 > 631-642

In this paper we report a systematic XAS study of a set of samples in which Cu(II) was progressively added to complexes in which Zn(II) was bound to the tetra-octarepeat portion of the prion protein. This work extends previous EPR and XAS analysis in which, in contrast, the effect of adding Zn(II) to Cu(II)–tetra-octarepeat complexes was investigated. Detailed structural analysis of the XAS spectra...

article

Molecular and Functional Analysis of Human β-Defensin 3 Action at Melanocortin Receptors

Matthew A. Nix, Christopher B. Kaelin, Tina Ta, Allison Weis, more

Chemistry & Biology > 2013 > 20 > 6 > 784-795

The β-defensins are a class of small, cationic proteins first recognized as antimicrobial components of the innate and adaptive immune system. More recently, one of the major β-defensins produced in skin, β-defensin 3, has been discovered to function as a melanocortin receptor ligand in vivo and in vitro, but its biophysical and pharmacological basis of action has been enigmatic. Here, we report functional...

article

Zinc Drives a Tertiary Fold in the Prion Protein with Familial Disease Mutation Sites at the Interface

Ann R. Spevacek, Eric G.B. Evans, Jillian L. Miller, Heidi C. Meyer, more

Structure > 2013 > 21 > 2 > 236-246

The cellular prion protein PrP ^C consists of two domains—a flexible N-terminal domain, which participates in copper and zinc regulation, and a largely helical C-terminal domain that converts to β sheet in the course of prion disease. These two domains are thought to be fully independent and noninteracting. Compelling cellular and biophysical studies, however, suggest a higher order structure...

article

The rich electrochemistry and redox reactions of the copper sites in the cellular prion protein

Feimeng Zhou, Glenn L. Millhauser

Coordination Chemistry Reviews > 2012 > 256 > 19-20 > 2285-2296

This paper reviews recent electrochemical studies of the copper complexes of prion protein (PrP) and its related peptides, and correlates their redox behavior to chemical and biologically relevant reactions. Particular emphasis is placed on the difference in redox properties between copper in the octarepeat (OR) and the non-OR domains of PrP, as well as differences between the high and low copper...

article

Melanocortin‐1 receptor‐mediated signalling pathways activated by NDP‐MSH and HBD3 ligands

Kimberley A. Beaumont, Darren J. Smit, Yan Yan Liu, Eric Chai, more

Pigment Cell & Melanoma Research > 25 > 3 > 370 - 374

Binding of melanocortin peptide agonists to the melanocortin‐1 receptor of melanocytes results in eumelanin production, whereas binding of the agouti signalling protein inverse agonist results in pheomelanin synthesis. Recently, a novel melanocortin‐1 receptor ligand was reported. A β‐defensin gene mutation was found to be responsible for black coat colour in domestic dogs. Notably, the human equivalent,...

article

Human β‐defensin 3 affects the activity of pro‐inflammatory pathways associated with MyD88 and TRIF

Fiona Semple, Heather MacPherson, Sheila Webb, Sarah L. Cox, more

European Journal of Immunology > 41 > 11 > 3291 - 3300

β‐Defensins are cationic host defense peptides that form an amphipathic structure stabilized by three intramolecular disulfide bonds. They are key players in innate and adaptive immunity and have recently been shown to limit the production of pro‐inflammatory cytokines in TLR4‐stimulated macrophages. In the present study, we investigate the mechanism underlying the anti‐inflammatory effect of human...

article

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

Katerina Levitan, David Chereau, Samuel I.A. Cohen, Tuomas P.J. Knowles, more

Journal of Molecular Biology > 2011 > 411 > 2 > 329-333

α-Synuclein (α-syn) is the major component of filamentous Lewy bodies found in the brains of patients diagnosed with Parkinson's disease (PD). Recent studies demonstrate that, in addition to the wild-type sequence, α-syn is found in several modified forms, including truncated and phosphorylated species. Although the mechanism by which the neuronal loss in PD occurs is unknown, aggregation and fibril...

article

Copper Redox Cycling in the Prion Protein Depends Critically on Binding Mode

Lin Liu, Dianlu Jiang, Alex McDonald, Yuanqiang Hao, more

Journal of the American Chemical Society > 2011 > 133 > 31 > 12229 - 12237

article

Melanocortin MC1 receptor in human genetics and model systems

Kimberley A. Beaumont, Shu S. Wong, Stephen A. Ainger, Yan Yan Liu, more

European Journal of Pharmacology > 2011 > 660 > 1 > 103-110

The melanocortin MC ₁ receptor is a G-protein coupled receptor expressed in the melanocytes of the skin and hair and is known for its key role in the regulation of human pigmentation. Melanocortin MC ₁ receptor activation after ultraviolet radiation exposure results in a switch from the red/yellow pheomelanin to the brown/black eumelanin pigment synthesis within cutaneous melanocytes;...

article

Coordination Features and Affinity of the Cu ²⁺ Site in the α-Synuclein Protein of Parkinson’s Disease

Christopher G. Dudzik, Eric D. Walter, Glenn L. Millhauser

Biochemistry > 2011 > 50 > 11 > 1771 - 1777

article

Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism

Mira P. Patel, Camila S. Cribb Fabersunne, Ying-kui Yang, Christopher B. Kaelin, more

Journal of Molecular Biology > 2010 > 404 > 1 > 45-55

Agouti-related protein (AgRP) and agouti signaling protein (ASIP) are homologs that play critical roles in energy balance and pigmentation, respectively, by functioning as antagonistic ligands at their cognate melanocortin receptors. Signaling specificity is mediated in part through receptor binding selectivity brought about by alterations in the cysteine-rich carboxy-terminal domains of the ligands...

article

Quantification of the Binding Properties of Cu ²⁺ to the Amyloid Beta Peptide: Coordination Spheres for Human and Rat Peptides and Implication on Cu ²⁺ -Induced Aggregation ^†

Lian Hong, Tessa M. Carducci, William D. Bush, Christopher G. Dudzik, more

The Journal of Physical Chemistry B > 2010 > 114 > 34 > 11261 - 11271

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Glenn L. Millhauser

Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin‐4 receptor

Impacts of oxygen vacancies on the electrocatalytic activity of AuTiO2 nanocomposites towards oxygen reduction

Interaction between Prion Protein's Copper-Bound Octarepeat Domain and a Charged C-Terminal Pocket Suggests a Mechanism for N-Terminal Regulation

Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System

n‐Dopants Based on Dimers of Benzimidazoline Radicals: Structures and Mechanism of Redox Reactions

Tyrosine nitration in peptides by peroxynitrite generated in situ in a light-controlled platform: Effects of pH and thiols

Combined EXAFS and DFT Structure Calculations Provide Structural Insights into the 1:1 Multi‐Histidine Complexes of Cu^II, Cu^I, and Zn^II with the Tandem Octarepeats of the Mammalian Prion Protein

Adapter reagents for protein site specific dye labeling

Copper–zinc cross-modulation in prion protein binding

Molecular and Functional Analysis of Human β-Defensin 3 Action at Melanocortin Receptors

Zinc Drives a Tertiary Fold in the Prion Protein with Familial Disease Mutation Sites at the Interface

The rich electrochemistry and redox reactions of the copper sites in the cellular prion protein

Melanocortin‐1 receptor‐mediated signalling pathways activated by NDP‐MSH and HBD3 ligands

Human β‐defensin 3 affects the activity of pro‐inflammatory pathways associated with MyD88 and TRIF

Conserved C-Terminal Charge Exerts a Profound Influence on the Aggregation Rate of α-Synuclein

Copper Redox Cycling in the Prion Protein Depends Critically on Binding Mode

Melanocortin MC1 receptor in human genetics and model systems

Coordination Features and Affinity of the Cu ²⁺ Site in the α-Synuclein Protein of Parkinson’s Disease

Loop-Swapped Chimeras of the Agouti-Related Protein and the Agouti Signaling Protein Identify Contacts Required for Melanocortin 1 Receptor Selectivity and Antagonism

Quantification of the Binding Properties of Cu ²⁺ to the Amyloid Beta Peptide: Coordination Spheres for Human and Rat Peptides and Implication on Cu ²⁺ -Induced Aggregation ^†

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Glenn L. Millhauser

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options