Search results for: Richard B. van Breemen

Items from 1 to 20 out of 116 results

article

Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents

Guannan Li, Charlotte Simmler, Luying Chen, Dejan Nikolic, more

European Journal of Pharmaceutical Sciences > 2017 > 109 > C > 182-190

The potential of licorice dietary supplements to interact with drug metabolism was evaluated by testing extracts of three botanically identified licorice species (Glycyrrhiza glabra L., Glycyrrhiza uralensis Fish. ex DC. and Glycyrrhiza inflata Batalin) and 14 isolated licorice compounds for inhibition of 9 cytochrome P450 enzymes using a UHPLC-MS/MS cocktail assay. G. glabra showed moderate inhibitory...

article

Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats

Annekathrin M. Keiler, Dana Macejova, Birgit M. Dietz, Judy L. Bolton, more

The Journal of Steroid Biochemistry and Molecular Biology > 2017 > 174 > C > 234-241

Supplements with estrogenic activities are intensively investigated as potential alternatives for the treatment of menopausal symptoms. These investigations include studies on their safety regarding potential breast cancer risks. Therefore, the aim of this study was to assess whether or not a standardized hops (Humulus lupulus) extract, containing 0.42% of the estrogenic flavanone, 8-prenylnaringenin,...

article

A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus

Annekathrin M. Keiler, Janina Helle, Manuela I. Bader, Tino Ehrhardt, more

Phytomedicine > 2017 > 34 > C > 50-58

Hops (Humulus lupulus (L.)) dietary supplements are of interest as herbal remedies to alleviate menopausal symptoms, such as hot flushes, depression and anxiety. So far, the evidence regarding estrogenic and related properties of hops preparations has been considered insufficient for a market authorization for menopausal indications.The study aims to investigate a chemically standardized hops extract...

article

Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A

Charlotte Simmler, David C. Lankin, Dejan Nikolić, Richard B. van Breemen, more

Fitoterapia > 2017 > 121 > C > 6-15

In an effort to explore the residual complexity of naturally occurring chalcones from the roots of Glycyrrhiza inflata (Fabaceae), two new licochalcone A (LicA) derivatives were isolated as trace metabolites from enriched fractions. Both constituents contain a dihydrofuran moiety linked to carbons C-4 and C-5 of the retrochalcone core. Compound 1 (LicAF1) represents a new chemical entity, whereas...

article

Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer

Yachana Kataria, Ryan J. Deaton, Erika Enk, Ming Jin, more

BMC Gastroenterology > 2016 > 16 > 1 > 1-12

Background Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increased oxidative stress is regarded as a major mechanism of HCV-related liver disease progression. Deficiencies in retinoid and carotenoid antioxidants may represent a major modifiable...

article

Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples

Laura N Vandenberg, Roy R Gerona, Kurunthachalam Kannan, Julia A Taylor, more

Environmental Health > 2016 > 15 > 1 > 1-1

article

Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry

Ana Lis Moyano, Guannan Li, Aurora Lopez-Rosas, Jan-Eric Månsson, more

Analytical Biochemistry > 2014 > 467 > C > 31-39

Sulfated galactosylceramides (sulfatides) are glycosphingolipids associated with cholesterol- and sphingolipid-enriched membrane microdomains (lipid rafts) and are highly expressed in brain tissue. Although it is known that sulfatide species show heterogeneity in their fatty acid acyl group composition throughout brain development, their lipid raft distribution and biological relevance is poorly understood...

article

Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops

Richard B. van Breemen, Yang Yuan, Suzanne Banuvar, Lee P. Shulman, more

Molecular Nutrition & Food Research > 58 > 10 > 1962 - 1969

ScopeWomen seeking alternatives to hormone‐replacement therapy for menopausal symptoms often try botanical dietary supplements containing extracts of hops (Humulus lupulus L.). Hops contain 8‐prenylnaringenin (8‐PN), a potent phytoestrogen, the related flavanones 6‐prenylnaringenin and isoxanthohumol (IX), and the prenylated chalcone xanthohumol (XN). Methods and resultsAfter chemically and biologically...

article

Antiproliferative and quinone reductase-inducing activities of withanolides derivatives

Manuela E. García, Viviana E. Nicotra, Juan C. Oberti, Carla Ríos-Luci, more

European Journal of Medicinal Chemistry > 2014 > 82 > Complete > 68-81

Two new and five known withanolides (jaborosalactones 2, 3, 4, 5, and 24) were isolated from the leaves of Jaborosa runcinata Lam. We also obtained some derivatives from jaborosalactone 5, which resulted to be the major isolated metabolite. The natural compounds as well as derivatives were evaluated for their antiproliferative activity and the induction of quinone reductase 1 (QR1; NQ01) activity...

article

Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols

Yang Yuan, Xi Qiu, Dejan Nikolić, Shao-Nong Chen, more

European Journal of Pharmaceutical Sciences > 2014 > 53 > Complete > 55-61

As hops (Humulus lupulus L.) are used in the brewing of beer and by menopausal women as estrogenic dietary supplements, the potential for hop extracts and hop constituents to cause drug–botanical interactions by inhibiting human cytochrome P450 enzymes was investigated. Inhibition of major human cytochrome P450 enzymes by a standardized hop extract and isolated hop prenylated phenols was evaluated...

article

A round robin approach to the analysis of bisphenol a (BPA) in human blood samples

Laura N Vandenberg, Roy R Gerona, Kurunthachalam Kannan, Julia A Taylor, more

Environmental Health > 2014 > 13 > 1 > 1-20

Background Human exposure to bisphenol A (BPA) is ubiquitous, yet there are concerns about whether BPA can be measured in human blood. This Round Robin was designed to address this concern through three goals: 1) to identify collection materials, reagents and detection apparatuses that do not contribute BPA to serum; 2) to identify sensitive and precise methods to accurately measure unconjugated BPA...

article

Lipidated steroid saponins from Dioscorea villosa (wild yam)

Shi-Hui Dong, Geping Cai, José G. Napolitano, Dejan Nikolić, more

Fitoterapia > 2013 > 91 > C > 113-124

Two groups of lipidated steroid saponins including seven new compounds (2, 3, 5, and 7–10) were isolated from the widely used botanical, wild yam (Dioscorea villosa), employing a fractionation protocol of metabolomic mining. This methodology recently led to the isolation of 14 diarylheptanoids from the same plant. Together with these lipidated steroid saponins, they establish additional new markers...

article

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles

Aldo Andreani, Alberto Leoni, Alessandra Locatelli, Rita Morigi, more

European Journal of Medicinal Chemistry > 2013 > 68 > Complete > 412-421

The synthesis of new imidazo[2,1-b]thiazoles bearing phenolic groups is reported. These compounds and some previously described analogs were evaluated as antioxidant agents with three chemical model systems, and cancer chemopreventive potential was examined by inhibition of NO production, TNF-α activated NFκB activity, and aromatase activity, as well as induction of QR1 and RXRE binding. Two of the...

article

Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E2 in laying hen ovaries

Erfan Eilati, Karen Hales, Yan Zhuge, Kristine Ansenberger Fricano, more

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) > 2013 > 89 > 4 > 179-187

Prevention of ovarian cancer is the best approach for reducing the impact of this deadly disease. The laying hen is a robust model of spontaneous ovarian cancer that recapitulates the human disease. Dietary intervention with flaxseed, the richest vegetable source of omega-3 fatty acids (OM-3FAs) and phytoestrogen lignans, demonstrate the potential for effective prevention and amelioration of ovarian...

article

Transarterial Sorafenib Chemoembolization: Preliminary Study of Technical Feasibility in a Rabbit Model

Ron C. Gaba, Felix Y. Yap, Elizabeth M. Martinez, Yongchao Li, more

Journal of Vascular and Interventional Radiology > 2013 > 24 > 5 > 744-750

To test the feasibility of targeted intraarterial administration of the tyrosine kinase inhibitor chemotherapeutic agent sorafenib to inhibit embolotherapy-induced tumor angiogenesis and reduce systemic drug side effects.The left hepatic lobes of five New Zealand White rabbits (mean weight, 2.7 kg±0.2) were treated with chemoembolization with sorafenib and ethiodized oil emulsion, followed by immediate...

article

Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant

Yang Yuan, Li-Fang Yu, Xi Qiu, Alan P. Kozikowski, more

Journal of Chromatography B > 2013 > 912 > Complete > 38-42

LF-3-88 (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol) was identified as a highly selective α4β2-nAChRs partial agonist, with a K _i value of 0.4nM and EC ₅₀ value of 110nM. A sensitive and selective ultra high pressure liquid chromatography–tandem mass spectrometry (UHPLC–MS–MS) method was developed and validated to study the pharmacokinetics profile of this compound...

article

Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose

Aditya Sudheer Vaidya, Raghupathi Neelarapu, Antonett Madriaga, He Bai, more

Bioorganic & Medicinal Chemistry Letters > 2012 > 22 > 21 > 6621-6627

A novel series of HDAC8 inhibitors without a zinc-chelating hydroxamic acid moiety is reported. Photoaffinity labeling and molecular modeling studies suggest that these ligands are likely to bind in an ‘upside-down’ fashion in a secondary binding site proximal to the main catalytic site. The most potent ligand in the series exhibits an IC ₅₀ of 28μM for HDAC8 and is found to inhibit the deacetylation...

article

Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2

Aditya Sudheer Vaidya, Bhargava Karumudi, Emma Mendonca, Antonett Madriaga, more

Bioorganic & Medicinal Chemistry Letters > 2012 > 22 > 15 > 5025-5030

The design, modeling, synthesis, biological evaluation of a novel series of photoreactive benzamide probes for class I HDAC isoforms is reported. The probes are potent and selective for HDAC1 and 2 and are efficient in crosslinking to HDAC2 as demonstrated by photolabeling experiments. The probes exhibit a time-dependent inhibition of class I HDACs. The inhibitory activities of the probes were influenced...

article

Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.)

Dejan Nikolić, Tanja Gödecke, Shao-Nong Chen, Jerry White, more

Fitoterapia > 2012 > 83 > 3 > 441-460

Black cohosh preparations are popular dietary supplements among women seeking alternative treatments for menopausal complaints. For decades, triterpene glycosides and phenolic acids have dominated the phytochemical and biomedical research on this plant. In this study, we provide evidence that black cohosh contains an unexpected and highly diverse group of secondary nitrogenous metabolites previously...

article

Special issue honoring Catherine Fenselau

Igor A. Kaltashov, Richard B. van Breemen

International Journal of Mass Spectrometry > 2012 > 312 > Complete > 1-4

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Search results for: Richard B. van Breemen

Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents

Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats

A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus

Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A

Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer

Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples

Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry

Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops

Antiproliferative and quinone reductase-inducing activities of withanolides derivatives

Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols

A round robin approach to the analysis of bisphenol a (BPA) in human blood samples

Lipidated steroid saponins from Dioscorea villosa (wild yam)

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles

Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E2 in laying hen ovaries

Transarterial Sorafenib Chemoembolization: Preliminary Study of Technical Feasibility in a Rabbit Model

Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant

Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose

Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2

Mass spectrometric dereplication of nitrogen-containing constituents of black cohosh (Cimicifuga racemosa L.)

Special issue honoring Catherine Fenselau

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