Search results for: Baruch Velan

Items from 1 to 20 out of 27 results

article

Overcoming the effect of pandemic fatigue on vaccine hesitancy—Will belief in science triumph?

Moran Bodas, Arielle Kaim, Baruch Velan, Arnona Ziv, more

Journal of Nursing Scholarship > 55 > 1 > 262 - 271

Purpose The study aims to examine the factors that impact vaccination uptake and additional protective behavior during the fourth wave of the pandemic in Israel, whereas the “pandemic fatigue” phenomenon has been identified as a hurdle to adherence to protective health behaviors against coronavirus disease 2019 (COVID‐19). Design A cross‐sectional, structured questionnaire was utilized for this...

article

Truth-telling and doctor-assisted death as perceived by Israeli physicians

Baruch Velan, Arnona Ziv, Giora Kaplan, Carmit Rubin, more

BMC Medical Ethics > 2019 > 20 > 1 > 1-13

Background Medicine has undergone substantial changes in the way medical dilemmas are being dealt with. Here we explore the attitude of Israeli physicians to two debatable dilemmas: disclosing the full truth to patients about a poor medical prognosis, and assisting terminally ill patients in ending their lives. Methods Attitudes towards medico-ethical dilemmas were examined through a nationwide...

article

On the implications of desexualizing vaccines against sexually transmitted diseases: health policy challenges in a multicultural society

Baruch Velan, Yaacov Yadgar

Israel Journal of Health Policy Research > 2017 > 6 > 1 > 1-12

Two vaccines against sexually transmitted infections are included in many national vaccination programs: Hepatitis B Virus (HBV) vaccine and Human Papilloma Virus (HPV) vaccine. The trajectories of the implementation of these two programs were marked by differences in the way the sexual context of risk was communicated to the public. These trajectories fluctuated between full accounts of the sexual...

chapter

Vaccination with Plasmid DNA Expressing the Yersinia pestis Capsular Protein F1 Protects Mice Against Plague

Haim Grosfeld, Tamar Bino, Yehuda Flashner, Raphael Ber, more

Advances in Experimental Medicine and Biology > The Genus Yersinia > Diseases, Vaccines and Diagnostics > 423-424

chapter

Identification of Genes Involved in Yersinia pestis Virulence by Signature-tagged Mutagenesis

Yehuda Flashner, Emanuelle Mamroud, Avital Tidhar, Raphael Ber, more

Advances in Experimental Medicine and Biology > The Genus Yersinia > Evolution and Genomics > 31-33

chapter

Evaluation of Protective Immunity Induced by Yersinia enterocolitica Type-III Secretion System Mutants

Emanuelle Mamroud, Yehuda Flashner, Avital Tidhar, Raphael Ber, more

Advances in Experimental Medicine and Biology > The Genus Yersinia > Diseases, Vaccines and Diagnostics > 425-430

chapter

The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization

Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen, more

The Challenge of Highly Pathogenic Microorganisms > 89-98

The encounter between invading microorganisms and dendritic cells (DC) triggers a series of events which include uptake and degradation of the microorganism, induction of a cell maturation process, as well as enhancement of DC migration to the draining lymph nodes. Bacteria of the genera Yersinia and Francisella have developed different strategies to counteract these events as a measure to evade host...

book

The Challenge of Highly Pathogenic Microorganisms

Avigdor Shafferman, Arie Ordentlich, Baruch Velan, Springer Netherlands

This book addresses the unique features of four microorganisms that constitute the top bioterror threat agents: Bacillus anthracis; Yersinia pestis, Francisella tularensis and Orthopoxviruses. Side-by-side updated information about their pathogenisis, virulence and epidemiology is provided in a single volume, allowing for evaluation of common features as well as common strategies for defense. Classical...

article

Vaccine hesitancy as self-determination: an Israeli perspective

Baruch Velan

Israel Journal of Health Policy Research > 2016 > 5 > 1 > 1-6

Vaccine hesitancy can be portrayed as a broad spectrum of phenomena, ranging from a genuine call for help to complete defiance of authorities. The emphasis here is made on mid-spectrum hesitancy; hesitancy as an act of personal exploration and deliberation whether to get vaccinated or not. This form of vaccine hesitancy can be identified in the attitude of the Israeli public towards routine childhood...

article

Major motives in non-acceptance of A/H1N1 flu vaccination: The weight of rational assessment

Baruch Velan, Giora Kaplan, Arnona Ziv, Valentina Boyko, more

Vaccine > 2011 > 29 > 6 > 1173-1179

Recent efforts of health authorities to promote vaccination against influenza A/H1N1 were met with low compliance rates in most industrialized countries. Here we analyzed the attitudes of the Israeli public towards A/H1N1 vaccination based on a telephone survey conducted several months after the peak of the outbreak. The findings attest to the low uptake of the A/H1N1 vaccine (17%) in Israel, and...

article

Next generation OP-bioscavengers: A circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics

Chanoch Kronman, Ofer Cohen, Ohad Mazor, Arie Ordentlich, more

Chemico-Biological Interactions > 2010 > 187 > 1-3 > 253-258

We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme...

article

Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response

Shlomo Lustig, Galia Maik-Rachline, Nir Paran, Sharon Melamed, more

Vaccine > 2009 > 27 > 11 > 1691-1699

The therapeutic potential of human vaccinia immunoglobulin (VIG) in orthopoxvirus infection was examined using two mouse models for human poxvirus, based on Ectromelia virus and Vaccinia Western Reserve (WR) respiratory infections. Despite the relatively fast clearance of human VIG from mice circulation, a single VIG injection protected immune-competent mice against both infections. Full protection...

article

Flexibility versus “rigidity” of the functional architecture of AChE active center

Avigdor Shafferman, Dov Barak, Dana Stein, Chanoch Kronman, more

Chemico-Biological Interactions > 2008 > 175 > 1-3 > 166-172

Functional architecture of the AChE active center appears to be characterized by both structural “rigidity”, necessary to stabilize the catalytic triad as well as by flexibility in accommodating the different, high affinity AChE ligands. These seemingly conflicting structural properties of the active center are demonstrated through combination of structural methods with kinetic studies of the enzyme...

article

Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague

Ayelet Zauberman, Sara Cohen, Yinon Levy, Gideon Halperin, more

Vaccine > 2008 > 26 > 13 > 1616-1625

Plague is a life-threatening disease caused by Yersinia pestis, for which effective-licensed vaccines and reliable predictors of in vivo immunity are lacking. V antigen (LcrV) is a major Y. pestis virulence factor that mediates translocation of the cytotoxic Yersinia protein effectors (Yops). It is a well-established protective antigen and a part of currently tested plague subunit vaccines. We have...

article

Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents

Dov Barak, Arie Ordentlich, Dana Kaplan, Chanoch Kronman, more

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 219-226

Determination of the 3D-structure of acetylcholinesterase (AChE) of Torpedo californica over a decade ago, and more recently that of human enzyme together with extensive targeted mutagenesis of the mammalian AChEs led to a fine mapping of the multiple functional domains within the active center of the enzyme. Many of the contributions of this active center architecture to accommodation of noncovalent...

article

Functional requirements for the optimal catalytic configuration of the AChE active center

Avigdor Shafferman, Dov Barak, Dana Kaplan, Arie Ordentlich, more

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 123-131

Functional analysis of the HuAChE active center architecture revealed that accommodation of structurally diverse substrates and other ligands is achieved through interactions with specific subsites such as the acyl pocket, cation binding site, hydrophobic site or the oxyanion hole. Recent studies have begun to unravel the role of this active center architecture in maintaining the optimal catalytic...

article

The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers

Arie Ordentlich, Dov Barak, Gali Sod-Moriah, Dana Kaplan, more

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 191-198

The reactivity of human acetylcholinesterase (HuAChE) toward the chemical warfare agent VX {O-ethyl S-[2-(diisopropylamino)ethyl] methyl-phosphonothioate} and its stereoselectivity toward the P ^S -enantiomer were investigated by examining the reactivity of HuAChE and its mutant derivatives toward purified enantiomers of VX and its noncharged isostere nc-VX [O-ethyl S-(3-isopropyl-4-methyl-pentyl)...

article

Host-regulated disposition of mammalian AChEs

Chanoch Kronman, Ofer Cohen, Baruch Velan, Avigdor Shafferman

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 51-55

Primates are characterized by a paucity of soluble acetylcholinesterase (AChE) in the circulation at the adult stage, where the predominant circulating cholinesterase is butyrylcholinesterase. In recent years, we subjected recombinant human and bovine acetylcholinesterase to extensive pharmacokinetic studies in mice, an animal system which also displays very low levels of circulating AChE. In this...

article

Stereoselectivity toward VX Is Determined by Interactions with Residues of the Acyl Pocket as Well as of the Peripheral Anionic Site of AChE ^†

Arie Ordentlich, Dov Barak, Gali Sod-Moriah, Dana Kaplan, more

Biochemistry > 2004 > 43 > 35 > 11255 - 11265

article

Is Aromaticity Essential for Trapping the Catalytic Histidine 447 in Human Acetylcholinesterase? ^†

Dana Kaplan, Dov Barak, Arie Ordentlich, Chanoch Kronman, more

Biochemistry > 2004 > 43 > 11 > 3129 - 3136

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INFONA - science communication portal

Search results for: Baruch Velan

Overcoming the effect of pandemic fatigue on vaccine hesitancy—Will belief in science triumph?

Truth-telling and doctor-assisted death as perceived by Israeli physicians

On the implications of desexualizing vaccines against sexually transmitted diseases: health policy challenges in a multicultural society

Vaccination with Plasmid DNA Expressing the Yersinia pestis Capsular Protein F1 Protects Mice Against Plague

Identification of Genes Involved in Yersinia pestis Virulence by Signature-tagged Mutagenesis

Evaluation of Protective Immunity Induced by Yersinia enterocolitica Type-III Secretion System Mutants

The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization

The Challenge of Highly Pathogenic Microorganisms

Vaccine hesitancy as self-determination: an Israeli perspective

Major motives in non-acceptance of A/H1N1 flu vaccination: The weight of rational assessment

Next generation OP-bioscavengers: A circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics

Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response

Flexibility versus “rigidity” of the functional architecture of AChE active center

Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague

Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents

Functional requirements for the optimal catalytic configuration of the AChE active center

The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers

Host-regulated disposition of mammalian AChEs

Stereoselectivity toward VX Is Determined by Interactions with Residues of the Acyl Pocket as Well as of the Peripheral Anionic Site of AChE ^†

Is Aromaticity Essential for Trapping the Catalytic Histidine 447 in Human Acetylcholinesterase? ^†

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