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MUC2 glycoprotein, produced by the epithelium of the colon and built up mainly of repeat units of 1PTTTPITTTTTVTPTPTPTGTQT23, can be overexpressed or underglycosylated in gastrointestinal diseases, e.g. in case of colon carcinoma. We have been studying the epitope structure of the MUC2 by focusing on the repeat unit with the mucin peptide specific MAb 996 monoclonal antibody. This antibody recognizes...
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