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A theranostic, enzymatically biodegradable nanoplatform based on luminescent carbon particles decorated with cucurbit[6]uril is introduced for enhancing the solubility of niclosamide, a STAT‐3 inhibitor. On page 5845, D. Pan and co‐workers reveal that, overall, the supramolecular chemistry on nanocarbon acts as a novel arsenal for STAT‐3 inhibition in vitro and in vivo and provides signature intracellular...
Signal transducer and activator of transcription factor 3 (STAT‐3) is known to be overexpressed in cancer stem cells. Poor solubility and variable drug absorption are linked to low bioavailability and decreased efficacy. Many of the drugs regulating STAT‐3 expression lack aqueous solubility; hence hindering efficient bioavailability. A theranostics nanoplatform based on luminescent carbon particles...
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