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The aim of this work is to evaluate the influence of MgO, SrO and SiO 2 doping on mechanical and biological properties of β-tricalcium phosphate (β-TCP) to achieve controlled resorption kinetics of β-TCP system for maxillofacial and spinal fusion application. We prepared dense TCP compacts of four different compositions, i) pure β-TCP, ii) β-TCP with 1.0wt.% MgO+1.0wt.% SrO, iii) β-TCP with...
The aim of this study was to determine whether clodronate reduced the incidence of vertebral fractures in patients with osteoporosis. We report here the interim analysis after 1 year of a 3-year double-blind placebo-controlled study. The objectives of the interim analysis were to determine whether there was a trend in fracture frequency and to examine the effects of clodronate on bone mineral density...
Previous evidence implicating paramyxoviruses in the aetiopathology of Paget's disease of bone has been controversial. While several groups have demonstrated the presence of paramyxoviruses using electron microscopy, immunohistochemistry, and molecular biological techniques, others have found no evidence of viruses using reverse transcriptase-polymerase chain reaction (RT-PCR). We have previously...
This investigation examined which signal pathways are of relevance in growth factor-stimulated bone cell mitogenesis. Platelet-derived growth factor (PDGF) and insulin-like growth factor-II (IGF-II) were potent mitogens for both the MG-63 osteoblast cell line and for primary cultures of human osteoblasts (HObs). The mitogenic action of both IGF-II and PDGF was attenuated by pertussis toxin (Ptx),...
Two families are described in whom both fathers were found to be hypocalcaemic when their sons presented with fits and hypocalcaemia in infancy. The diagnosis was assumed to be familial hypoparathyroidism and treatment with calcium supplements and vitamin D analogues was started. This treatment, whilst correcting hypocalcaemia, produced a rise in serum creatinine. One child repeatedly developed...
Coeliac disease is a major cause of intestinal malabsorption which has important effects on the absorption of calcium and hence is likely to impact upon the skeleton. In order to assess the effect of coeliac disease on bone we have measured the bone mass in 27 patients with histologically proven coeliac disease who had been prescribed a gluten free diet.Bone mass was measured using QCT of the spine,...
The effects of the active metabolite of vitamin D, 1,25 dihydroxyvitamin D 3 (1,25D), are mediated via the vitamin D receptor (VDR). 1,25D is known to have profound effects on bone resorption, but proof that the human osteoclast expresses VDR in vivo is absent. Receptors have been demonstrated in osteoblasts, and it has been generally accepted that the effects of 1,25D on formed osteoclasts...
1,24(S)-Dihydroxyvitamin D 2 (1,24D 2 ) has been identified in rats given vitamin D 2 and can also be synthesised in hepatoma cellsin vitro by 24-hydroxylation of 1α-(OH)vitamin D 2 . This natural analogue is of interest because it binds avidly to the vitamin D receptor but has low calcaemic activity relative to 1,25D 3 . No similar pathway has been reported...
Assessment of calcium intake is important for an understanding of the relationship between calcium nutrition and bone status. Most previous means of assessing calcium intake have been difficult and time consuming. We report the results of using an abbreviated dietary history to assess the calcium intake in a group of subjects with a variety of different disorders of mineral metabolism.23 patients...
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