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Immune cells (leukocytes) and hematopoietic progenitor cells circulating the body must exit blood vessels near specific target sites of injury, infection, inflammation, or proliferation (Springer 1994; Butcher and Picker 1996; Mazo and von Andrian 1999). Recruitment of different subsets of leukocytes and circulating malignant cells to these sites is tightly regulated by sequential adhesive interactions...
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