Search results for: Shasha Bai

Items from 1 to 20 out of 28 results

article

Epilepsy center characteristics and geographic region influence presurgical testing in the United States

Stephanie M. Ahrens, Kristen H. Arredondo, Anto I. Bagić, Shasha Bai, more

Epilepsia > 64 > 1 > 127 - 138

Objective Persons with drug‐resistant epilepsy may benefit from epilepsy surgery and should undergo presurgical testing to determine potential candidacy and appropriate intervention. Institutional expertise can influence use and availability of evaluations and epilepsy surgery candidacy. This census survey study aims to examine the influence of geographic region and other center characteristics on...

article

Impaired ventilation during 6‐min walk test in congenital central hypoventilation syndrome

Radhika N. Ghosh, Lokesh Guglani, Adrianna L. Westbrook, Chad Y. Mao, more

Pediatric Pulmonology > 57 > 7 > 1660 - 1667

Background Patients with congenital central hypoventilation syndrome (CCHS) can develop hypoxemia and hypercapnia during exercise. However, there is limited literature on cardiorespiratory responses during submaximal exercise and their correlation with paired‐like homeobox 2B (PHOX2B) genotype. Objectives To assess oxygen saturation (SpO₂), end‐tidal carbon dioxide (ETCO₂), heart rate (HR), and...

article

Unexpected decline in pediatric asthma morbidity during the coronavirus pandemic

Lisa Ulrich, Charlie Macias, Ashish George, Shasha Bai, more

Pediatric Pulmonology > 56 > 7 > 1951 - 1956

The Coronavirus disease 2019 (COVID‐19) pandemic profoundly impacted health care utilization. We evaluated asthma‐related emergency department (ED) and inpatient health care utilization by a county‐specific Medicaid population, ages 2–18, during the COVID‐19 pandemic and compared it to utilization from a 3‐year average including 2017–2019. All‐cause ED utilization and asthma medication fill rates...

article

Spirulina breath test indicates differences in gastric emptying based on age, gender, and BMI

Danielle K. Orsagh‐Yentis, Shasha Bai, Adam Bobbey, Caitlin Hayes, more

Neurogastroenterology & Motility > 33 > 6 > n/a - n/a

Background Measurements of gastric emptying (GE) by scintigraphy in the pediatric population are based on adult standards. Due to radiation exposure, scintigraphy cannot be performed on healthy children to establish norms of GE in the pediatric population. Stable isotope breath tests (GEBTs) pose no such health risk to children. This study sought to determine the feasibility of a GEBT in children...

article

Irreversible effects of trichloroethylene on the gut microbial community and gut‐associated immune responses in autoimmune‐prone mice

Sangeeta Khare, Kuppan Gokulan, Katherine Williams, Shasha Bai, more

Journal of Applied Toxicology > 39 > 2 > 209 - 220

The developing immune system is particularly sensitive to immunotoxicants. This study assessed trichloroethylene (TCE)‐induced effects on the gut microbiome and cytokine production during the development in mice. Mice were exposed to TCE (0.05 or 500 μg/mL) at the levels that approximate to environmental or occupational exposure, respectively. Mice were subjected to a continuous developmental exposure...

article

Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits

Ting‐Ting Hou, Feng Lin, Shasha Bai, Mario A. Cleves, more

Genetic Epidemiology > 43 > 1 > 24 - 36

The manifestation of complex traits is influenced by gene–gene and gene–environment interactions, and the identification of multifactor interactions is an important but challenging undertaking for genetic studies. Many complex phenotypes such as disease severity are measured on an ordinal scale with more than two categories. A proportional odds model can improve statistical power for these outcomes,...

article

Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

Meijing Liu, Guohui Zhang, Chunge Zheng, Meng Song, more

British Journal of Pharmacology > 175 > 17 > 3563 - 3580

Background and Purpose Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a naturally occurring coumarin, is the main bioactive ingredient of Angelica dahurica Radix, which is regularly used to treat the common cold and intestinal disorders. However, there are no data on the protective effects of IMP against...

article

Searching for the Best Oral Treatment for Hypoglycemic Newborns

Paul J. Rozance, Shasha Bai, Jeff R. Kaiser

The Journal of Pediatrics > 2017 > 190 > C > 10-12

article

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Sarah B. Mulkey, Raghu H. Ramakrishnaiah, Robert C. McKinstry, Taeun Chang, more

The Journal of Pediatrics > 2017 > 186 > C > 196-199

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P = .004). Higher injury volume correlated with lower 12-month neurodevelopmental scores.ClinicalTrials...

article

Pharmacokinetics of two 6‐mercaptopurine liquid formulations in children with acute lymphoblastic leukemia

Jaszianne A. Tolbert, Shasha Bai, Susan M. Abdel‐Rahman, Keith J. August, more

Pediatric Blood & Cancer > 64 > 8 > n/a - n/a

Background A liquid formulation of 6‐mercaptopurine (6‐MP) was recently approved by the Food and Drug Administration (Purixan®) based on bioavailability (BA) data from healthy adults. We examined the pharmacokinetics (PK) and BA of 6‐MP in children with acute lymphoblastic leukemia (ALL) comparing a marketed tablet, two extemporaneously prepared liquid formulations, and data from the approved liquid...

article

Effect of ventilator mode on patient‐ventilator synchrony and work of breathing in neonatal pigs

Shayna M. Wood, Tracy L. Thurman, Shirley J. Holt, Shasha Bai, more

Pediatric Pulmonology > 52 > 7 > 922 - 928

BACKGROUND Patient‐ventilator asynchrony can result in increased work of breathing (WOB) and need for increased sedation, as well as respiratory muscle fatigue and prolonged mechanical ventilation. Different ventilator modes may result in varying degrees of asynchrony and WOB. OBJECTIVE The objectives of this study were to assess the incidence of asynchrony and the effect of asynchrony on WOB in...

article

An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Dean W. Roberts, William M. Lee, Jack A. Hinson, Shasha Bai, more

Clinical Gastroenterology and Hepatology > 2017 > 15 > 4 > 555-562.e3

A rapid and reliable point-of-care assay to detect acetaminophen protein adducts in the serum of patients with acute liver injury could improve diagnosis and management. AcetaSTAT is a competitive immunoassay used to measure acetaminophen protein adducts formed by toxic metabolites in serum samples from patients. We compared the accuracy of AcetaSTAT vs high-pressure liquid chromatography with electrochemical...

article

Palatability of a novel oral formulation of prednisone in healthy young adults

Shasha Bai, Nathan Dormer, Catherine Shoults, Amanda Meyer, more

Journal of Pharmacy and Pharmacology > 69 > 4 > 489 - 496

Objectives Prednisone is a widely used anti‐inflammatory for a variety of conditions. While oral liquid formulations of prednisone enable weight‐based dosing, children frequently find them to be objectionable due to bitter taste. This limitation of prednisone can adversely impact patient acceptance and may result in non‐compliance. Efforts to mask flavours often result in poorly controlled, heterogeneous...

article

CONGENITAL HEART SURGERY IN PATIENTS WITH TRISOMY 13 ASSOCIATED WITH LOWER IN-HOSPITAL MORTALITY

Katherine Kosiv, Jeffrey Gossett, Shasha Bai, Ronnie Collins

Journal of the American College of Cardiology > 2017 > 69 > 11(S) > 589

article

The Effect of Early Feeding on Initial Glucose Concentrations in Term Newborns

Yin Zhou, Shasha Bai, Joshua A. Bornhorst, Nahed O. Elhassan, more

The Journal of Pediatrics > 2017 > 181 > C > 112-115

To evaluate the influence of early feeding on initial glucose concentrations in healthy term newborns who were not at risk for hypoglycemia.This retrospective observational study was conducted at the University of Arkansas for Medical Sciences where universal early glucose screening was standard of care for newborn infants. Plasma glucose concentrations were compared in term infants born in 2008 who...

article

School-Age Test Proficiency and Special Education After Congenital Heart Disease Surgery in Infancy

Sarah B. Mulkey, Shasha Bai, Chunqiao Luo, Jordyn E. Cleavenger, more

The Journal of Pediatrics > 2016 > 178 > C > 47-54.e1

To evaluate test proficiency and the receipt of special education services in school-age children who had undergone surgery for congenital heart disease (CHD) at age <1 year.Data from Arkansas-born children who underwent surgery for CHD at Arkansas Children's Hospital at age <1 year between 1996 and 2004 were linked to state birth certificates and the Arkansas Department of Education longitudinal...

article

Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells

Kathleen M. Gilbert, Sarah J. Blossom, Stephen W. Erickson, Brannon Broadfoot, more

Toxicology Letters > 2016 > 260 > C > 1-7

CD4⁺ T cells in female MRL+/+ mice exposed to solvent and water pollutant trichloroethylene (TCE) skew toward effector/memory CD4⁺ T cells, and demonstrate seemingly non-monotonic alterations in IFN-γ production. In the current study we examined the mechanism for this immunotoxicity using effector/memory and naïve CD4⁺ T cells isolated every 6 weeks during a 40 week exposure to TCE (0.5mg/ml in drinking...

article

Improving knowledge, technical skills, and confidence among pediatric health care providers in the management of chronic tracheostomy using a simulation model

Amit Agarwal, Nancy Marks, Valerie Wessel, Denise Willis, more

Pediatric Pulmonology > 51 > 7 > 696 - 704

ObjectiveThe results from a recent national survey about catastrophic complications following tracheostomy revealed that the majority of events involved a loss of airway. Most of the events due to airway loss involved potentially correctable deficits in caregiver education. Training in a simulated environment allows skill acquisition without compromising patient safety. We assessed the knowledge and...

article

Successful development of a direct observation program to measure health care worker hand hygiene using multiple trained volunteers

W. Matthew Linam, Michele D. Honeycutt, Craig H. Gilliam, Christy M. Wisdom, more

American Journal of Infection Control > 2016 > 44 > 5 > 544-547

Direct observation of health care worker (HCW) hand hygiene (HH) remains the gold standard, but implementation is challenging. Our objective was to develop an accurate HH observation program using multiple HCW volunteers.HH compliance was defined as correct HH performed before and after contact with a patient or a patient's environment. HCW volunteers from each unit at our children's hospital were...

article

Amplitude-Integrated EEG in Newborns With Critical Congenital Heart Disease Predicts Preoperative Brain Magnetic Resonance Imaging Findings

Sarah B. Mulkey, Vivien L. Yap, Shasha Bai, Raghu H. Ramakrishnaiah, more

Pediatric Neurology > 2015 > 52 > 6 > 599-605

The study aims are to evaluate cerebral background patterns using amplitude-integrated electroencephalography in newborns with critical congenital heart disease, determine if amplitude-integrated electroencephalography is predictive of preoperative brain injury, and assess the incidence of preoperative seizures. We hypothesize that amplitude-integrated electroencephalography will show abnormal background...

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INFONA - science communication portal

Search results for: Shasha Bai

Epilepsy center characteristics and geographic region influence presurgical testing in the United States

Impaired ventilation during 6‐min walk test in congenital central hypoventilation syndrome

Unexpected decline in pediatric asthma morbidity during the coronavirus pandemic

Spirulina breath test indicates differences in gastric emptying based on age, gender, and BMI

Irreversible effects of trichloroethylene on the gut microbial community and gut‐associated immune responses in autoimmune‐prone mice

Generalized multifactor dimensionality reduction approaches to identification of genetic interactions underlying ordinal traits

Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium‐induced colitis in mice

Searching for the Best Oral Treatment for Hypoglycemic Newborns

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Pharmacokinetics of two 6‐mercaptopurine liquid formulations in children with acute lymphoblastic leukemia

Effect of ventilator mode on patient‐ventilator synchrony and work of breathing in neonatal pigs

An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure

Palatability of a novel oral formulation of prednisone in healthy young adults

CONGENITAL HEART SURGERY IN PATIENTS WITH TRISOMY 13 ASSOCIATED WITH LOWER IN-HOSPITAL MORTALITY

The Effect of Early Feeding on Initial Glucose Concentrations in Term Newborns

School-Age Test Proficiency and Special Education After Congenital Heart Disease Surgery in Infancy

Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells

Improving knowledge, technical skills, and confidence among pediatric health care providers in the management of chronic tracheostomy using a simulation model

Successful development of a direct observation program to measure health care worker hand hygiene using multiple trained volunteers

Amplitude-Integrated EEG in Newborns With Critical Congenital Heart Disease Predicts Preoperative Brain Magnetic Resonance Imaging Findings

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