Search results for: Patrycja Nowak‐Sliwinska

Items from 1 to 20 out of 37 results

article

Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

Rudolf A. Boer, Jean‐Sébastien Hulot, Carlo Gabriele Tocchetti, Joseph Pierre Aboumsallem, more

European Journal of Heart Failure > 22 > 12 > 2272 - 2289

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the...

article

Cell death rocks

Arjan W. Griffioen, Patrycja Nowak-Sliwinska

Apoptosis > 2019 > 24 > 3-4 > 205-207

article

Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Victor LJL Thijssen, Yvette WJ Paulis, Patrycja Nowak‐Sliwinska, Katrin L Deumelandt, more

The Journal of Pathology > 246 > 4 > 447 - 458

Aggressive tumor cells can adopt an endothelial cell‐like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis. This adoptive mechanism is referred to as vascular mimicry and it is associated with poor survival in cancer patients. To what extent tumor cells capable of vascular mimicry phenocopy the angiogenic cascade is still poorly explored. Here, we...

article

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers

Marchien G. Dallinga, Bahar Yetkin-Arik, Richelle P. Kayser, Ilse M. C. Vogels, more

Angiogenesis > 2018 > 21 > 4 > 823-836

Tip cells, the leading cells of angiogenic sprouts, were identified in cultures of human umbilical vein endothelial cells (HUVECs) by using CD34 as a marker. Here, we show that tip cells are also present in primary human microvascular endothelial cells (hMVECs), a more relevant endothelial cell type for angiogenesis. By means of flow cytometry, immunocytochemistry, and qPCR, it is shown that endothelial...

article

Apoptosis on the move

Patrycja Nowak-Sliwinska, Arjan W. Griffioen

Apoptosis > 2018 > 23 > 5-6 > 251-254

article

An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature

Elisabeth J.M. Huijbers, Judy R. van Beijnum, Chung T. Lê, Sofya Langman, more

Vaccine > 2018 > 36 > 21 > 3054-3060

The induction of an antibody response against self-antigens requires a conjugate vaccine technology, where the self-antigen is conjugated to a foreign protein sequence, and the co-application of a potent adjuvant. The choice of this foreign sequence is crucial as a very strong antibody response towards it may compromise the anti-self immune response. Here, we aimed to optimize the conjugate design...

article

Consensus guidelines for the use and interpretation of angiogenesis assays

Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, more

Angiogenesis > 2018 > 21 > 3 > 425-532

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations...

article

Apoptosis turns 21

Arjan W. Griffioen, Patrycja Nowak-Sliwinska

Apoptosis > 2017 > 22 > 12 > 1485-1486

article

A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7)

Judy R. Beijnum, Patrycja Nowak-Sliwinska, Maaike Berkel, Tse J. Wong, more

Angiogenesis > 2017 > 20 > 4 > 641-654

Tumor angiogenesis is characterized by deregulated gene expression in endothelial cells (EC). While studies until now have mainly focused on overexpressed genes in tumor endothelium, we here describe the identification of transcripts that are repressed in tumor endothelium and thus have potential suppressive effects on angiogenesis. We identified nineteen putative angiosuppressor genes, one of them...

article

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

Iwona Stawoska, Waldemar Tejchman, Olga Mazuryk, Antonín Lyčka, more

Journal of Heterocyclic Chemistry > 54 > 5 > 2889 - 2897

Selected rhodanine‐3‐carboxylic acids derivatives were synthesized to determine the influence of the structure and the length of the linker between the carboxyl group and the nitrogen atom (N‐3) in the 2‐thioxo‐4‐thiazolidinone ring on their activity, monitored via interactions with human serum albumin. Based on fluorescence studies, we concluded that the length of the linker has a limited impact...

article

Erratum to: miRNAs: micro-managers of anticancer combination therapies

Judy R. Beijnum, Elisa Giovannetti, Dennis Poel, Patrycja Nowak-Sliwinska, more

Angiogenesis > 2017 > 20 > 4 > 673-673

The online version of the original article can be found under doi: 10.1007/s10456-017-9545-x .

article

Insulin‐like growth factor axis targeting in cancer and tumour angiogenesis – the missing link

Judy R. van Beijnum, Wietske Pieters, Patrycja Nowak‐Sliwinska, Arjan W. Griffioen

Biological Reviews > 92 > 3 > 1755 - 1768

Numerous molecular players in the process of tumour angiogenesis have been shown to offer potential for therapeutic targeting. Initially denoted to be involved in malignant transformation and tumour progression, the insulin‐like growth factor (IGF) signalling axis has been subject to therapeutic interference, albeit with limited clinical success. More recently, IGFs and their receptors have received...

article

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska

Mutation Research/Reviews in Mutation Research > 2017 > 773 > C > 242-262

The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system are essential for a successful research project. Currently, various sophisticated...

article

miRNAs: micro-managers of anticancer combination therapies

Judy R. Beijnum, Elisa Giovannetti, Dennis Poel, Patrycja Nowak-Sliwinska, more

Angiogenesis > 2017 > 20 > 2 > 269-285

Angiogenesis is one of the hallmarks of cancer progression and as such has been considered a target of therapeutic interest. However, single targeted agents have not fully lived up to the initial promise of anti-angiogenic therapy. Therefore, it has been suggested that combining therapies and agents will be the way forward in the oncology field. In recent years, microRNAs (miRNAs) have received considerable...

article

Angiogenesis inhibitors in combinatorial approaches

Patrycja Nowak-Sliwinska, Arjan W. Griffioen

Angiogenesis > 2017 > 20 > 2 > 183-184

article

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

Robert H. Berndsen, U. Kulsoom Abdul, Andrea Weiss, Marloes Zoetemelk, more

Angiogenesis > 2017 > 20 > 2 > 245-267

Cancer cells are often dependent on epigenetic pathways for their survival. Consequently, drugs that target the epigenome, rather than the underlying DNA sequence, are currently attracting considerable attention. In recent years, the first epigenetic drugs have been approved for cancer chemotherapy, mainly for hematological applications. Limitations in single-drug efficacies have thus far limited...

article

A key role for galectin‐1 in sprouting angiogenesis revealed by novel rationally designed antibodies

Judy R. Beijnum, Victor L. Thijssen, Tilman Läppchen, Tse J. Wong, more

International Journal of Cancer > 139 > 4 > 824 - 835

Galectins are carbohydrate binding proteins that function in many key cellular processes. We have previously demonstrated that galectins are essential for tumor angiogenesis and their expression is associated with disease progression. Targeting galectins is therefore a potential anti‐angiogenic and anti‐cancer strategy. Here, we used a rational approach to generate antibodies against a specific member...

article

Role of the tumor stroma in resistance to anti-angiogenic therapy

Elisabeth J.M. Huijbers, Judy R. van Beijnum, Victor L. Thijssen, Siamack Sabrkhany, more

Drug Resistance Updates > 2016 > 25 > C > 26-37

Several angiogenesis inhibitors are currently used in the clinic for treatment of cancer. While anti-angiogenesis treatment can improve treatment outcome, the overall benefit on patient survival is still rather limited. This is partially explained by intrinsic or acquired resistance of tumor cells to angiostatic drugs. In addition, it has become evident that extrinsic mechanisms are also involved...

article

Chlorambucil conjugates of dinuclear p-cymene ruthenium trithiolato complexes: synthesis, characterization and cytotoxicity study in vitro and in vivo

David Stíbal, Bruno Therrien, Georg Süss-Fink, Patrycja Nowak-Sliwinska, more

JBIC Journal of Biological Inorganic Chemistry > 2016 > 21 > 4 > 443-452

Four diruthenium trithiolato chlorambucil conjugates have been prepared via Steglich esterification from chlorambucil and the corresponding trithiolato precursors. All conjugates are highly cytotoxic towards human ovarian A2780 and A2780cisR cancer cell lines with IC₅₀ values in the nanomolar range. The conjugates exhibit selectivity towards A2780 cells as compared to non-cancerous HEK293 cells, while...

article

Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies

Gajendra Gupta, Patrycja Nowak-Sliwinska, Noelia Herrero, Paul J. Dyson, more

Journal of Organometallic Chemistry > 2015 > 796 > C > 59-64

A series of arene ruthenium metalla-rectangles of general formula [(η⁶-p-cymene)₄Ru₄(μ₄-embelin)₂(μ₂-N∩N)₂](CF₃SO₃)₄ was prepared from the embelin-derived metalla-clip (η⁶-p-cymene)₂Ru₂(μ₄-embelin)Cl₂ (1), silver triflate and several linear ditopic N-ligands (N∩N); pyrazine (prz), 4,4'-bipyridine (bpy), 1,2-bis(4-pyridyl)ethylene (bpe), 4,4'-azopyridine (azp) and di(pyridin-4-yl)oxalamide (bpo). The...

Publication date

Set your own date range

Keywords

Data set

Springer (16)
Elsevier (12)
Wiley (6)
ACS (2)
PSJD (1)

Journal

Angiogenesis (11)
Apoptosis (3)
Microvascular Research (3)
Journal of Medicinal Chemistry (2)
Acta Biochimica Polonica (1)
BBA - Reviews on Cancer (1)
Biochemical and Biophysical Research Communications (1)
Biological Reviews (1)
Cellular and Molecular Life Sciences (1)
Drug Resistance Updates (1)
European Journal of Heart Failure (1)
Inorganica Chimica Acta (1)
International Journal of Cancer (1)
JBIC Journal of Biological Inorganic Chemistry (1)
Journal of Heterocyclic Chemistry (1)
Journal of Organometallic Chemistry (1)
Mutation Research/Reviews in Mutation Research (1)
Photochemistry and Photobiology (1)
Progress in Retinal and Eye Research (1)
The Journal of Pathology (1)
Vaccine (1)
Vascular Pharmacology (1)
more

INFONA - science communication portal

Search results for: Patrycja Nowak‐Sliwinska

Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

Cell death rocks

Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers

Apoptosis on the move

An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature

Consensus guidelines for the use and interpretation of angiogenesis assays

Apoptosis turns 21

A genomic screen for angiosuppressor genes in the tumor endothelium identifies a multifaceted angiostatic role for bromodomain containing 7 (BRD7)

Spectral Characteristic and Preliminary Anticancer Activity in vitro of Selected Rhodanine‐3‐carboxylic Acids Derivatives

Erratum to: miRNAs: micro-managers of anticancer combination therapies

Insulin‐like growth factor axis targeting in cancer and tumour angiogenesis – the missing link

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

miRNAs: micro-managers of anticancer combination therapies

Angiogenesis inhibitors in combinatorial approaches

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment

A key role for galectin‐1 in sprouting angiogenesis revealed by novel rationally designed antibodies

Role of the tumor stroma in resistance to anti-angiogenic therapy

Chlorambucil conjugates of dinuclear p-cymene ruthenium trithiolato complexes: synthesis, characterization and cytotoxicity study in vitro and in vivo

Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Patrycja Nowak‐Sliwinska

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options