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Lymphocytes use a considerable amount of energy, mainly in the form of ATP, especially when they become stimulated following activation by antibodies or mitogens. Cellular respiration is the major energy source, and in quiescent cells the ATP produced is used to drive protein synthesis and sodium transport. In stimulated cells there is significantly higher ATP production to balance the higher ATP...
The first quantitative findings on the energy metabolism of human immunecells are presented. In quiescent peripheral blood mononuclear cells(PBMC) protein biosynthesis and Na+,K+-ATPase activity eachaccounted for 8% of cellular oxygen consumption. Stimulation with 25, 50,and 75 μg Con A/ml (1.25, 2.5 or 3.75 μg/106 cells) increased totaloxygen consumption within seconds by 8, 36, and 53%, respectively...
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