K. Muruga Poopathi Raja

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Modulating the Structural Properties of α,γ‐Hybrid Peptides by α‐Amino Acid Residues: Uniform 12‐Helix Versus “Mixed” 12/10‐Helix

Rajkumar Misra, K. Muruga Poopathi Raja, Hans‐Jörg Hofmann, Hosahudya N. Gopi

Chemistry – A European Journal > 23 > 65 > 16644 - 16652

The most important natural α‐ and 3₁₀‐helices are stabilized by unidirectional intramolecular hydrogen bonds along the helical cylinder. In contrast, we report here on 12/10‐helical conformations with alternately changing hydrogen‐bond directionality in sequences of α,γ‐hybrid peptides P1–P5 [P1: Boc‐Ala‐Aic‐Ala‐Aic‐COOH; P2: Boc‐Leu‐Aic‐Leu‐Aic‐OEt; P3: Boc‐Leu‐Aic‐Leu‐Aic‐Leu‐Aic‐Aib‐OMe; P4: Boc‐Ala‐Aic‐Ala‐Aic‐Ala‐Aic‐Ala‐OMe;...

article

Structural Dimorphism of Achiral α,γ‐Hybrid Peptide Foldamers: Coexistence of 12‐ and 15/17‐Helices

Rajkumar Misra, Abhijith Saseendran, Gijo George, Kuruva Veeresh, more

Chemistry – A European Journal > 23 > 15 > 3764 - 3772

Here, novel 12‐helices in α,γ‐hybrid peptides composed of achiral α‐aminoisobutyric acid (Aib) and 4‐aminoisocaproic acid (Aic, doubly homologated Aib) monomers in 1:1 alternation are reported. The 12‐helices were indicated by solution and crystal structural analyses of tetra‐ and heptapeptides. Surprisingly, single crystals of the longer nonapeptide displayed two different helix types: the novel...

article

Non‐classical Helices with cis Carbon–Carbon Double Bonds in the Backbone: Structural Features of α,γ‐Hybrid Peptide Foldamers

Mothukuri Ganesh Kumar, Varsha J. Thombare, Mona M. Katariya, Kuruva Veeresh, more

Angewandte Chemie > 128 > 27 > 7978 - 7982

The impact of geometrically constrained cis α,β‐unsaturated γ‐amino acids on the folding of α,γ‐hybrid peptides was investigated. Structure analysis in single crystals and in solution revealed that the cis carbon–carbon double bonds can be accommodated into the 12‐helix without deviation from the overall helical conformation. The helical structures are stabilized by 4→1 hydrogen bonding in a similar...

article

Non‐classical Helices with cis Carbon–Carbon Double Bonds in the Backbone: Structural Features of α,γ‐Hybrid Peptide Foldamers

Mothukuri Ganesh Kumar, Varsha J. Thombare, Mona M. Katariya, Kuruva Veeresh, more

Angewandte Chemie International Edition > 55 > 27 > 7847 - 7851

The impact of geometrically constrained cis α,β‐unsaturated γ‐amino acids on the folding of α,γ‐hybrid peptides was investigated. Structure analysis in single crystals and in solution revealed that the cis carbon–carbon double bonds can be accommodated into the 12‐helix without deviation from the overall helical conformation. The helical structures are stabilized by 4→1 hydrogen bonding in a similar...

article

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, more

Cell Reports > 2016 > 14 > 9 > 2127-2141

Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP). β-secretase inhibitors reduce Aβ levels, but mechanism-based side effects arise because they also inhibit β-cleavage of non-amyloid substrates like Neuregulin...

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Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

Anupam Bandyopadhyay, Sachitanand M. Mali, Pooja Lunawat, K. Muruga Poopathi Raja, more

Organic Letters > 2011 > 13 > 17 > 4482 - 4485

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Search results for: K. Muruga Poopathi Raja

Modulating the Structural Properties of α,γ‐Hybrid Peptides by α‐Amino Acid Residues: Uniform 12‐Helix Versus “Mixed” 12/10‐Helix

Structural Dimorphism of Achiral α,γ‐Hybrid Peptide Foldamers: Coexistence of 12‐ and 15/17‐Helices

Non‐classical Helices with cis Carbon–Carbon Double Bonds in the Backbone: Structural Features of α,γ‐Hybrid Peptide Foldamers

Non‐classical Helices with cis Carbon–Carbon Double Bonds in the Backbone: Structural Features of α,γ‐Hybrid Peptide Foldamers

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

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INFONA - science communication portal

Search results for: K. Muruga Poopathi Raja

Modulating the Structural Properties of α,γ‐Hybrid Peptides by α‐Amino Acid Residues: Uniform 12‐Helix Versus “Mixed” 12/10‐Helix

Structural Dimorphism of Achiral α,γ‐Hybrid Peptide Foldamers: Coexistence of 12‐ and 15/17‐Helices

Non‐classical Helices with cis Carbon–Carbon Double Bonds in the Backbone: Structural Features of α,γ‐Hybrid Peptide Foldamers

Non‐classical Helices with cis Carbon–Carbon Double Bonds in the Backbone: Structural Features of α,γ‐Hybrid Peptide Foldamers

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

Synthesis and Structural Investigations of Functionalizable Hybrid β-Hairpin

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