Search results for: Lars S. Rasmussen

Items from 1 to 20 out of 85 results

article

Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study

Helene Dalsten, Vera Crone, Jacob Steinmetz, Christine L. Rosager, more

Acta Anaesthesiologica Scandinavica > 68 > 6 > 737 - 744

Background Suxamethonium is hydrolysed by butyrylcholinesterase (BChE) and a low BChE activity can result in a prolonged duration of action of suxamethonium. The BChE activity is reduced during pregnancy and postpartum period by up to 33%. However, it can also be reduced by mutations in the BChE gene. In this study, we assessed BChE activity and mutations in the BChE gene in pregnant and postpartum...

article

Transcutaneous carbon dioxide monitoring during prolonged apnoea with high‐flow nasal oxygen

Pernille Pape, Zofia M. Piosik, Camilla M. Kristensen, Jesper Dirks, more

Acta Anaesthesiologica Scandinavica > 67 > 5 > 649 - 654

Background The duration of apnoeic oxygenation with high‐flow nasal oxygen is limited by hypercapnia and acidosis and monitoring of arterial carbon dioxide level is therefore essential. We have performed a study in patients undergoing prolonged apnoeic oxygenation where we monitored the progressive hypercapnia with transcutaneous carbon dioxide. In this paper, we compared the transcutaneous carbon...

article

Intra‐operative blood transfusion in elderly patients on antithrombotic therapy

Caroline Hjelmdal, Christina Draegert, Morten Vester‐Andersen, Ana Kowark, more

Acta Anaesthesiologica Scandinavica > 67 > 4 > 412 - 421

Background Many elderly patients are receiving antithrombotics, which may increase intra‐operative blood loss. We aimed to assess whether chronic antithrombotic therapy was associated with intra‐operative transfusion of packed red blood cells in patients at least 80 years of age undergoing elective procedures. Methods We performed a secondary analysis of the prospective, observational European...

article

Rocuronium 0.3 or 0.9 mg/kg comparing onset time, duration of action, and intubating conditions in patients 80 years and older: A randomized study

Matias Vested, Pernille Pape, Camilla M. Kristensen, Felicia Dinesen, more

Acta Anaesthesiologica Scandinavica > 66 > 7 > 811 - 817

Background Limited data exist about the optimal dose of rocuronium for intubation in elderly patients. We hypothesized that rocuronium 0.9 mg/kg would lead to a shorter onset time than 0.3 mg/kg in patients above 80 years. Methods Thirty‐four patients were randomized to either rocuronium 0.3 or 0.9 mg/kg. The primary outcome was onset time defined as time to train‐of‐four (TOF) count of 0. Other...

article

Supplemental oxygen for traumatic brain injury: A systematic review

Thea Ellehammer Hansen, Rasmus Ejlersgaard Christensen, Josefine Baekgaard, Jacob Steinmetz, more

Acta Anaesthesiologica Scandinavica > 66 > 3 > 307 - 316

Background Oxygen supplementation is recommended after traumatic brain injury (TBI) but excessive oxygen may be harmful. The aim of this study was to investigate the effect of supplemental oxygen or high/low inspiratory oxygen fraction (FiO₂) for TBI patients on in‐hospital mortality. Methods We searched Medline (Pubmed), EMBASE and the Cochrane Library for interventional and observational studies...

article

A blinded randomized study comparing intubating conditions after either rocuronium 0.6 mg·kg⁻¹ or remifentanil 2 µg·kg⁻¹ in elderly patients

Matias Vested, Anne Marie Sørensen, Cecilie Bjerring, Rasmus E. Christensen, more

Acta Anaesthesiologica Scandinavica > 65 > 10 > 1367 - 1373

Background To facilitate tracheal intubation, either a neuromuscular blocking agent or a bolus dose of remifentanil can be administered. We hypothesized that rocuronium 0.6 mg·kg⁻¹ provided a larger proportion of excellent intubating conditions compared to remifentanil 2 µg·kg⁻¹ in patients above 80 years. Methods A total of 78 patients were randomized to either rocuronium 0.6 mg·kg⁻¹ or remifentanil...

article

Supplemental oxygen therapy in trauma patients: An exploratory registry‐based study

Mathias A. Christensen, Jacob Steinmetz, George Velmahos, Lars S. Rasmussen

Acta Anaesthesiologica Scandinavica > 65 > 7 > 967 - 978

Background Supplemental oxygen (SO) is one of the most commonly administered drugs in trauma patients and is recommended by guidelines. However, evidence supporting uniform administration is sparse, and excess oxygen use has been shown to be harmful in other patient populations. We hypothesized that SO may be harmful in patients with oxygen saturation > 97%. Methods Patients with available information...

article

Anesthesiologists’ airway management expertise: Identifying subjective and objective knowledge gaps

Ebbe L. Bessmann, Lars S. Rasmussen, Lars Konge, Michael S. Kristensen, more

Acta Anaesthesiologica Scandinavica > 65 > 1 > 58 - 67

Background Failure in airway management continues to cause preventable patient harm, and the recommended continuing education is challenged by anesthesiologists’ unknown knowledge gaps. This study aimed to identify anesthesiologists’ subjective and objective knowledge gaps as well as areas where anesthesiologists are incorrect and unaware. Methods An adaptive E‐learning program with 103 questions...

article

Serum‐neuroproteins, near‐infrared spectroscopy, and cognitive outcome after beach‐chair shoulder surgery: Observational cohort study analyses

Jens Rolighed Larsen, Tina Kobborg, Pashtun Shahim, Kaj Blennow, more

Acta Anaesthesiologica Scandinavica > 65 > 1 > 26 - 33

Background Cerebral hypoxia may occur during surgery but currently used cerebral oxygenation saturation (rSO2) monitors remain controversial with respect to improving clinical outcome. Novel neuroprotein biomarkers are potentially released into systemic circulation and combined with near‐infrared spectroscopy (NIRS) could clarify the presence of per‐operative cerebral hypoxia. We investigated changes...

article

Ketamine for rapid sequence intubation in adult trauma patients: A retrospective observational study

Josefine S. Baekgaard, Trine G. Eskesen, Jae Moo Lee, Camilla Ikast Ottosen, more

Acta Anaesthesiologica Scandinavica > 64 > 9 > 1234 - 1242

Background In the trauma population, ketamine is commonly used during rapid sequence induction. However, as ketamine has been associated with important side effects, this study sought to compare in‐hospital mortality in trauma patients after induction with ketamine versus other induction agents. Methods We retrospectively identified adult trauma patients intubated in the pre‐hospital phase or initially...

article

Smoking and risk of surgical bleeding: nationwide analysis of 5,452,411 surgical cases

Ask T. Nordestgaard, Lars S. Rasmussen, Martin Sillesen, Jacob Steinmetz, more

Transfusion > 60 > 8 > 1689 - 1699

BACKGROUND Although smoking is associated with several postoperative complications, a possible association with surgical bleeding remains unclear. We examined if smoking is associated with a higher risk of surgical bleeding. STUDY DESIGN AND METHODS We included patients from the American College of Surgeons National Surgical Quality Improvement Program 2007‐2016 from 680 hospitals across the United...

article

Onset time and duration of action of rocuronium 0.6 mg/kg in patients above 80 years of age: A comparison with young adults

Cecilie Bjerring, Matias Vested, Tobias Arleth, Kirsten Eriksen, more

Acta Anaesthesiologica Scandinavica > 64 > 8 > 1082 - 1088

Background The number of elderly is increasing, and a large proportion of these people will require surgery and anaesthesia. However, little data exist regarding rocuronium in patients above 80 years of age. The aim of this study was to determine the onset time and duration of action for rocuronium 0.6 mg/kg in patients above 80 years compared with young adults. Methods This prospective observational...

article

Long‐term survival and cognitive function according to blood pressure management during cardiac surgery. A follow‐up

Mo H. Larsen, Christina Draegert, Anne G. Vedel, Frederik Holmgaard, more

Acta Anaesthesiologica Scandinavica > 64 > 7 > 936 - 944

Background Cardiac surgery is associated with a risk of complications, including post‐operative cognitive dysfunction (POCD). In the randomized Perfusion Pressure Cerebral Infarcts (PPCI) trial, we allocated cardiac surgery patients to either a low‐target mean arterial pressure (40‐50 mm Hg) or a high‐target pressure (70‐80 mm Hg). The study found no difference in the volume of new ischemic cerebral...

article

Maintaining competence in airway management

Ebbe L. Bessmann, Lars S. Rasmussen, Lars Konge, Michael S. Kristensen, more

Acta Anaesthesiologica Scandinavica > 64 > 6 > 751 - 758

Background Airway management is a defining skill for anaesthesiologists. Anaesthesiologists must maintain and update these crucial skills throughout their career, but how this is best achieved remains unclear. This study aimed to clarify anaesthesiologists’ procedural volume, confidence in airway management and their current and preferred future educational strategies. Methods A questionnaire was...

article

Impact of Physician‐staffed Helicopters on Pre‐hospital Patient Outcomes: A systematic review

Bjarke Risgaard, Christina Draegert, Josefine S. Baekgaard, Jacob Steinmetz, more

Acta Anaesthesiologica Scandinavica > 64 > 5 > 691 - 704

Background Management of pre‐hospital patients remains a challenge. In developed countries a physician‐staffed helicopter emergency medical service (PS‐HEMS) is used in addition to ground emergency medical service (GEMS), but the effect is debated. This systematic review aimed to evaluate the effect of PS‐HEMS compared with GEMS on patient outcomes based on the published scientific literature. ...

article

Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study

Mattias Danielson, Andreas Wiklund, Fredrik Granath, Kaj Blennow, more

Annals of Neurology > 87 > 3 > 370 - 382

Objective Long‐term cognitive decline is an adverse outcome after major surgery associated with increased risk for mortality and morbidity. We studied the cerebrospinal fluid (CSF) and serum biochemical inflammatory response to a standardized orthopedic surgical procedure and the possible association with long‐term changes in cognitive function. We hypothesized that the CSF inflammatory response...

article

Hyperoxia and antioxidants during major non‐cardiac surgery and risk of cardiovascular events: Protocol for a 2 × 2 factorial randomised clinical trial

Cecilie Petersen, Frederik C. Loft, Eske K. Aasvang, Morten Vester‐Andersen, more

Acta Anaesthesiologica Scandinavica > 64 > 3 > 400 - 409

Background Myocardial injury after non‐cardiac surgery occurs in a high number of patients, resulting in increased mortality in the post‐operative period. The use of high inspiratory oxygen concentrations may cause hyperoxia, which is associated with impairment of coronary blood flow. Furthermore, the surgical stress response increases reactive oxygen species, which is involved in several perioperative...

article

Response letter to comments made by J. G. Förster, M. Pitkänen

Rasmus E. Christensen, Josefine S. Baekgaard, Lars S. Rasmussen

Acta Anaesthesiologica Scandinavica > 64 > 3 > 418 - 418

article

Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study

Matias Vested, Mona Tarpgaard, Kirsten Eriksen, Lars S. Rasmussen

Acta Anaesthesiologica Scandinavica > 64 > 2 > 168 - 172

Background The aim of this quality assurance study was to determine the proportion of patients with residual block (train‐of‐four (TOF) ratio <0.9) upon conclusion of surgery after a bolus of cisatracurium 0.1 mg/kg. It was considered good quality if less than 10% of the study population had residual block upon conclusion of surgery. Methods A total of 40 patients ≤3 years of age scheduled for...

article

Dental injuries in relation to general anaesthesia—A retrospective study

Rasmus Ejlersgaard Christensen, Josefine S. Baekgaard, Lars S. Rasmussen

Acta Anaesthesiologica Scandinavica > 63 > 8 > 993 - 1000

Background Dental injuries may occur during general anaesthesia, especially during airway management. The aim of this study was to describe cases of dental injury related to general anaesthesia, focusing on the type and extent of the injuries as well as the timing of recognition. Method We reviewed the nationwide electronic database available at the Danish Patient Compensation Association and scrutinized...

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INFONA - science communication portal

Search results for: Lars S. Rasmussen

Prolonged duration of action of suxamethonium in pregnant and postpartum patients: A registry study

Transcutaneous carbon dioxide monitoring during prolonged apnoea with high‐flow nasal oxygen

Intra‐operative blood transfusion in elderly patients on antithrombotic therapy

Rocuronium 0.3 or 0.9 mg/kg comparing onset time, duration of action, and intubating conditions in patients 80 years and older: A randomized study

Supplemental oxygen for traumatic brain injury: A systematic review

A blinded randomized study comparing intubating conditions after either rocuronium 0.6 mg·kg⁻¹ or remifentanil 2 µg·kg⁻¹ in elderly patients

Supplemental oxygen therapy in trauma patients: An exploratory registry‐based study

Anesthesiologists’ airway management expertise: Identifying subjective and objective knowledge gaps

Serum‐neuroproteins, near‐infrared spectroscopy, and cognitive outcome after beach‐chair shoulder surgery: Observational cohort study analyses

Ketamine for rapid sequence intubation in adult trauma patients: A retrospective observational study

Smoking and risk of surgical bleeding: nationwide analysis of 5,452,411 surgical cases

Onset time and duration of action of rocuronium 0.6 mg/kg in patients above 80 years of age: A comparison with young adults

Long‐term survival and cognitive function according to blood pressure management during cardiac surgery. A follow‐up

Maintaining competence in airway management

Impact of Physician‐staffed Helicopters on Pre‐hospital Patient Outcomes: A systematic review

Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study

Hyperoxia and antioxidants during major non‐cardiac surgery and risk of cardiovascular events: Protocol for a 2 × 2 factorial randomised clinical trial

Response letter to comments made by J. G. Förster, M. Pitkänen

Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study

Dental injuries in relation to general anaesthesia—A retrospective study

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