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Summary: Cryopreservation has been successfully used in the in vitro study of pharmacological responses of animal tissues and, to a limited extent, of human tissue. In this study, we examined the effect of cryopreservation on reactivity of human bronchus which was stored for a period of up to 3 weeks. Thirty-two bronchial rings were obtained from each of four transplantation donors (four male, aged...
Summary: Although tamour necrosis factor α (TNFα) may be involved in the pathology of asthma, little is known about its role in mediator release from inflammatory cells in human lung. We investigated whether TNFα induced histamine release from mast cells in human chopped lung tissue and whether it modulated antigen-induced release of histamine and leukotrienes C 4 /D 4 /E 4 ...
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