Search results for: Alessia Parodi

Items from 1 to 17 out of 17 results

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Characterization of T lymphocytes in severe COVID‐19 patients

Daniela Fenoglio, Chiara Dentone, Alessia Parodi, Antonio Di Biagio, more

Journal of Medical Virology > 93 > 9 > 5608 - 5613

In this observational study, 13 patients with severe COVID‐19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID‐19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible...

article

CD8+CD28−CD127loCD39+ regulatory T-cell expansion: A new possible pathogenic mechanism for HIV infection?

Daniela Fenoglio, Chiara Dentone, Alessio Signori, Antonio Di Biagio, more

Journal of Allergy and Clinical Immunology > 2018 > 141 > 6 > 2220-2233.e4

HIV-associated immunodeficiency is related to loss of CD4⁺ T cells. This mechanism does not explain certain manifestations of HIV disease, such as immunodeficiency events in patients with greater than 500 CD4⁺ T cells/μL. CD8⁺CD28⁻CD127^loCD39⁺ T cells are regulatory T (Treg) lymphocytes that are highly concentrated within the tumor microenvironment and never analyzed in the circulation of HIV-infected...

article

Impaired immune response to Candida albicans in cells from Fanconi anemia patients

Alessia Parodi, Francesca Kalli, Johanna Svahn, Giorgia Stroppiana, more

Cytokine > 2015 > 73 > 1 > 203-207

Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. Several studies show alterations of the immunological status of FA patients including defects in peripheral blood lymphocyte subsets, serum immunoglobulin levels, and inflammatory cytokines. However scanty information is available on the response of FA cells to specific infectious antigens. In...

article

Early and repeated IgG1Fc-pCons chimera vaccinations (GX101) improve the outcome in SLE-prone mice

Francesca Ferrera, Daniela Fenoglio, Maurizio Cutolo, Giuseppe Balbi, more

Clinical and Experimental Medicine > 2015 > 15 > 3 > 255-260

A previous study showed that a tolerogenic gene vaccine based on a IgG1Fc-pCons chimera (here named GX101) protects NZB/NZW mice from SLE development. The present study was aimed at identifying the most effective schedule of immunization and the possible involvement of CD4⁺ Foxp3⁺ Treg in the mechanism of action, in view of its eventual translation to the human studies. NZB/NZW mice were vaccinated...

article

Monomeric Aβ1–42 and RAGE: key players in neuronal differentiation

Sabrina Piras, Anna L. Furfaro, Alessandra Piccini, Mario Passalacqua, more

Neurobiology of Aging > 2014 > 35 > 6 > 1301-1308

The aggregation of amyloid-β (Aβ) peptides plays a crucial role in the onset and progression of Alzheimer's disease. Monomeric form of Aβ, indeed, could exert a physiological role. Considering the anti-oligomerization property of all-trans retinoic acid (ATRA), the involvement of monomeric Aβ1–42 in ATRA-induced neuronal differentiation has been investigated. Four-day ATRA treatment increases β-secretase...

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HO-1 up-regulation: A key point in high-risk neuroblastoma resistance to bortezomib

Anna Lisa Furfaro, Sabrina Piras, Mario Passalacqua, Cinzia Domenicotti, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 4 > 613-622

High-risk neuroblastoma (NB) is characterized by the development of chemoresistance, and bortezomib (BTZ), a selective inhibitor of proteasome, has been proposed in order to overcome drug resistance. Considering the involvement of the nuclear factor-erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the antioxidant and detoxifying ability of cancer cells, in this study we have investigated...

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Immunological profile of Fanconi anemia: A multicentric retrospective analysis of 61 patients

Elisabeth T. Korthof, Johanna Svahn, Regis Peffault Latour, Paola Terranova, more

American Journal of Hematology > 88 > 6 > 472 - 476

In this study, the immunological status of 61 patients with Fanconi anemia (FA) with advanced marrow failure before hematopoietic stem cell transplantation was analyzed by assessing the phenotype of peripheral blood lymphocytes, serum immunoglobulin (Ig) levels, and inflammatory cytokines. In patients with FA, total absolute lymphocytes (P < 0.0001), B cells (P < 0.0001), and NK cells (P = 0...

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Indoleamine 2,3 dioxygenase gene polymorphisms correlate with CD8+ Treg impairment in systemic sclerosis

Samuele Tardito, Simone Negrini, Giuseppina Conteduca, Francesca Ferrera, more

Human Immunology > 2013 > 74 > 2 > 166-169

Systemic sclerosis (SSc) is characterized by tissue fibrosis, vasculopathy and autoimmunity. Indoleamine 2,3 dioxygenase (IDO) plays a pivotal role in immunological tolerance modulating regulatory T cell (Treg) generation and function. Single nucleotide polymorphisms (SNPs) of IDO gene could impact on Treg function and predispose to autoimmunity. Here, the existence of an association between specific...

article

Fingolimod Modulates Peripheral Effector and Regulatory T Cells in MS Patients

Laura D. Serpero, Gilberto Filaci, Alessia Parodi, Florinda Battaglia, more

Journal of Neuroimmune Pharmacology > 2013 > 8 > 5 > 1106-1113

Multiple sclerosis (MS) is a complex neurological disease where, in genetically predisposed individuals, the unbalanced interplay between pathogenic and regulatory T cells will result in the progression of the autoimmune assault to neural antigens. Fingolimod (FTY720), an oral sphingosine 1-phosphate modulator recently approved for the treatment of MS, inhibits the egress of T cells from lymph nodes...

article

CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes

Alessia Parodi, Florinda Battaglia, Francesca Kalli, Francesca Ferrera, more

Cancer Immunology, Immunotherapy > 2013 > 62 > 5 > 851-862

CD39 is an ectoenzyme, present on different immune cell subsets, which mediates immunosuppressive functions catalyzing ATP degradation. It is not known whether CD39 is expressed and implicated in the activity of CD8+ regulatory T lymphocytes (Treg). In this study, CD39 expression and function was analyzed in both CD8+ and CD4+CD25^hi Treg from the peripheral blood of healthy donors as well as from...

article

A multi-peptide, dual-adjuvant telomerase vaccine (GX301) is highly immunogenic in patients with prostate and renal cancer

Daniela Fenoglio, Paolo Traverso, Alessia Parodi, Laura Tomasello, more

Cancer Immunology, Immunotherapy > 2013 > 62 > 6 > 1041-1052

Background Anti-tumor vaccination is a new frontier in cancer treatment applicable to immunogenic neoplasms such as prostate and renal cancers. GX301 is a vaccine constituted by four telomerase peptides and two adjuvants, Montanide ISA-51 and Imiquimod. Objective The aim of this study was to analyze safety and tolerability of GX301 in an open-label, phase I/II trial. Immunological and clinical responses...

article

Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases

Daniela Fenoglio, Francesca Bernuzzi, Florinda Battaglia, Alessia Parodi, more

Autoimmunity Reviews > 2012 > 12 > 2 > 300-304

Fibrotic autoimmune diseases are characterized by an inflammatory process in which fibrogenic cytokines, such as TGFβ and IL6, have a major role. Interestingly, these cytokines are also involved in the generation and function of both an effector T lymphocyte subpopulation, the Th17 cells, and the regulatory T lymphocytes (Treg). These evidences raised the hypothesis that an unbalanced equilibrium...

article

Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro

Santina Bruzzone, Florinda Battaglia, Elena Mannino, Alessia Parodi, more

Biochemical and Biophysical Research Communications > 2012 > 422 > 1 > 70-74

The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. In this study, we investigated the effect of exogenous ABA on fibroblasts obtained...

article

Cyclophosphamide inhibits the generation and function of CD8+ regulatory T cells

Ilaria Traverso, Daniela Fenoglio, Simone Negrini, Alessia Parodi, more

Human Immunology > 2012 > 73 > 3 > 207-213

CD8 ⁺ regulatory T cells (Treg) and CD4 ⁺ CD25 ⁺ Treg infiltrate human cancers, thus favoring tumor immune escape. Therefore, in the setting of antitumor therapeutic protocols, it is important to associate antitumor treatment with agents that are able to inhibit Treg function. Cyclophosphamide (CY) has been demonstrated to be effective in counteracting CD4 ⁺ CD25 ...

article

Resistance of neuroblastoma GI-ME-N cell line to glutathione depletion involves Nrf2 and heme oxygenase-1

Anna Lisa Furfaro, José Raúl Zumba Macay, Barbara Marengo, Mariapaola Nitti, more

Free Radical Biology and Medicine > 2012 > 52 > 2 > 488-496

Cancer cell survival is known to be related to the ability to counteract oxidative stress, and glutathione (GSH) depletion has been proposed as a mechanism to sensitize cells to anticancer therapy. However, we observed that GI-ME-N cells, a neuroblastoma cell line without MYCN amplification, are able to survive even if GSH-depleted by l-buthionine-(S,R)-sulfoximine (BSO). Here, we show that in GI-ME-N...

article

Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis

Daniela Fenoglio, Florinda Battaglia, Alessia Parodi, Silvia Stringara, more

Clinical Immunology > 2011 > 139 > 3 > 249-257

Aim of the study has been to understand the relationship between TH17 and Treg cell subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17 and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration in the peripheral blood was found to be increased in SSc patients with respect to healthy controls independently from type or stage...

article

Clinical scale ex vivo expansion of cord blood–derived outgrowth endothelial progenitor cells is associated with high incidence of karyotype aberrations

Mirko Corselli, Alessia Parodi, Massimo Mogni, Nadia Sessarego, more

Experimental Hematology > 2008 > 36 > 3 > 340-349

Endothelial progenitor cells (EPCs) are involved in neovessel formation. So far, therapeutic angiogenesis is hampered by the low frequency and limited proliferative potential of these cells isolated from peripheral blood. Recently, it has been shown that cord blood–derived EPCs (CB EPCs) can be ex vivo expanded on a clinical scale. In this study, we evaluated the expansion potential of CB EPCs together...

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