Search results for: Fekret Osman

Items from 1 to 8 out of 8 results

article

A Histone-Fold Complex and FANCM Form a Conserved DNA-Remodeling Complex to Maintain Genome Stability

Zhijiang Yan, Mathieu Delannoy, Chen Ling, Danielle Daee, more

Molecular Cell > 2010 > 37 > 6 > 865-878

FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks,...

article

The FANCM Ortholog Fml1 Promotes Recombination at Stalled Replication Forks and Limits Crossing Over during DNA Double-Strand Break Repair

Weili Sun, Saikat Nandi, Fekret Osman, Jong Sook Ahn, more

Molecular Cell > 2008 > 32 > 1 > 118-128

The Fanconi anemia (FA) core complex promotes the tolerance/repair of DNA damage at stalled replication forks by catalyzing the monoubiquitination of FANCD2 and FANCI. Intriguingly, the core complex component FANCM also catalyzes branch migration of model Holliday junctions and replication forks in vitro. Here we have characterized the ortholog of FANCM in fission yeast Fml1 in order to understand...

article

Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks

Fekret Osman, Matthew C. Whitby

DNA Repair > 2007 > 6 > 7 > 1004-1017

Cells of all living organisms have evolved complex mechanisms that serve to stabilise, repair and restart stalled, blocked and broken replication forks. The heterodimeric Mus81-Eme1/Mms4 structure-specific endonuclease appears to play an important role(s) in homologous recombination-mediated processing of such perturbed forks. This enzyme has been implicated in the cleavage of stalled and blocked...

article

Generating Crossovers by Resolution of Nicked Holliday Junctions - A Role for Mus81-Eme1 in Meiosis

Fekret Osman, Julie Dixon, Claudette L. Doe, Matthew C. Whitby

Molecular Cell > 2003 > 12 > 3 > 761-774

The double Holliday junction (dHJ) is generally regarded to be a key intermediate of meiotic recombination, whose resolution is critical for the formation of crossover recombinants. In fission yeast, the Mus81-Eme1 endonuclease has been implicated in resolving dHJs. Consistent with this role, we show that Mus81-Eme1 is required for generating meiotic crossovers. However, purified Mus81-Eme1 prefers...

article

Repair of UV damage in the fission yeast Schizosaccharomyces pombe

Shirley J. McCready, Fekret Osman, Akira Yasui

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2000 > 451 > 1-2 > 197-210

This review is concerned with repair and tolerance of UV damage in the fission yeast, Schizosaccharomyces pombe and with the differences between Sch. pombe and budding yeast, Saccharomyces cerevisiae in their response to UV irradiation. Sch. pombe is not as sensitive to ultra-violet radiation as Sac. cerevisiae nor are any of its mutants as sensitive as the most sensitive Sac. cerevisiae mutants....

article

The genetic control of spontaneous and UV-induced mitotic intrachromosomal recombination in the fission yeast Schizosaccharomyces pombe

Fekret Osman, Melissa Adriance, Shirley McCready

Current Genetics > 2000 > 38 > 3 > 113-125

Abstract An artificially created non-tandem heteroallelic duplication was constructed to assay mitotic intrachromosomal recombination in Schizosaccharomyces pombe. Two classes of recombinants could be distinguished: deletion-types, in which one copy of the duplicated sequence and the intervening sequence were lost, and conversion-types which retained the duplication. For spontaneous recombination,...

article

Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe

Fekret Osman, Shirley McCready

Molecular Genetics and Genomics > 1998 > 260 > 4 > 319-334

Abstract Caffeine potentiates the lethal effects of ultraviolet and ionising radiation on wild-type Schizosaccharomyces pombe cells. In previous studies this was attributed to the inhibition by caffeine of a novel DNA repair pathway in S. pombe that was absent in the budding yeast Saccharomyces cerevisiae. Studies with radiation-sensitive S. pombe mutants suggested that this caffeine-sensitive pathway...

article

Analysis of spontaneous and double-strand break-induced recombination in rad mutants of S. pombe

Elizabeth A. Fortunato, Fekret Osman, Suresh Subramani

Mutation Research-DNA Repair > 1996 > 364 > 3 > 147-160

Schizosaccharomyces pombe strains containing direct repeats of ade6 heteroalleles separated by a functionalura4 ⁺ gene, and a DNA site for induction of a double-strand break (DSB), have been used to analyze pathways of spontaneous and DSB-induced intrachromosomal mitotic recombination. These substrates yield Ade ⁺ Ura ⁺ convertants or Ade ⁺ Ura ^- deletions,...

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