Barbara Porton

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Synapsins regulate brain‐derived neurotrophic factor‐mediated synaptic potentiation and axon elongation by acting on membrane rafts

Hung‐Teh Kao, Kanghyun Ryoo, Albert Lin, Stephen R. Janoschka, more

European Journal of Neuroscience > 45 > 8 > 1085 - 1101

In neurons, intracellular membrane rafts are essential for specific actions of brain‐derived neurotrophic factor (BDNF), which include the regulation of axon outgrowth, growth cone turning and synaptic transmission. Virtually, all the actions of BDNF are mediated by binding to its receptor, TrkB. The association of TrkB with the tyrosine kinase, Fyn, is critical for its localization to intracellular...

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5.2 ASSOCIATION BETWEEN MOLECULAR MARKERS OF NEUROENDOCRINE FUNCTION AND CELLULAR METABOLISM WITH EARLY LIFE STRESS AND PSYCHOPATHOLOGY

Kathryn K. Ridout, Stephanie H. Parade, Linda L. Carpenter, Lawrence H. Price, more

Journal of the American Academy of Child & Adolescent Psychiatry > 2016 > 55 > 10(S) > S184

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Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Audrey R. Tyrka, Stephanie H. Parade, Lawrence H. Price, Hung-Teh Kao, more

Biological Psychiatry > 2016 > 79 > 2 > 78-86

Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation...

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Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Audrey R. Tyrka, Linda L. Carpenter, Hung-Teh Kao, Barbara Porton, more

Experimental Gerontology > 2015 > 66 > Complete > 17-20

Cellular aging plays a role in longevity and senescence, and has been implicated in medical and psychiatric conditions, including heart disease, cancer, major depression and posttraumatic stress disorder. Telomere shortening and mitochondrial dysfunction are thought to be central to the cellular aging process. The present study examined the association between mitochondrial DNA (mtDNA) copy number...

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Synapsin III: Role in neuronal plasticity and disease

Barbara Porton, William C. Wetsel, Hung-Teh Kao

Seminars in Cell and Developmental Biology > 2011 > 22 > 4 > 416-424

Synapsin III was discovered in 1998, more than two decades after the first two synapsins (synapsins I and II) were identified. Although the biology of synapsin III is not as well understood as synapsins I and II, this gene is emerging as an important factor in the regulation of the early stages of neurodevelopment and dopaminergic neurotransmission, and in certain neuropsychiatric illnesses. Molecular...

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In Response to “No Correlation Between Childhood Maltreatment and Telomere Length”

Audrey R. Tyrka, Lawrence H. Price, Hung-Teh Kao, Barbara Porton, more

Biological Psychiatry > 2010 > 68 > 6 > e23-e24

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Childhood Maltreatment and Telomere Shortening: Preliminary Support for an Effect of Early Stress on Cellular Aging

Audrey R. Tyrka, Lawrence H. Price, Hung-Teh Kao, Barbara Porton, more

Biological Psychiatry > 2010 > 67 > 6 > 531-534

Psychological stress and trauma are risk factors for several medical and psychiatric illnesses. Recent studies have implicated advanced cellular aging as a potential mechanism of this association. Telomeres, DNA repeats that cap the ends of chromosomes and promote stability, shorten progressively with each cell division; their length is a marker of biological aging. Based on previous evidence linking...

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Telomerase levels in schizophrenia: A preliminary study

Barbara Porton, Lynn E. DeLisi, Hilary C. Bertisch, Fei Ji, more

Schizophrenia Research > 2008 > 106 > 2-3 > 242-247

We previously demonstrated that telomere length was markedly reduced in peripheral blood lymphocytes from individuals with schizophrenia. Since reduced telomere length can be caused by decreased telomerase activity, we quantitated basal telomerase activity in peripheral blood lymphocytes derived from individuals with schizophrenia (n=53), unaffected relatives (n=31) and unrelated controls (n=59)....

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Strict regulation of gene expression from a high-copy plasmid utilizing a dual vector system

David F. Gruber, Vincent A. Pieribone, Barbara Porton, Hung-Teh Kao

Protein Expression and Purification > 2008 > 60 > 1 > 53-57

High-copy plasmids are useful for producing large quantities of plasmid DNA, but are generally inadequate for tightly regulating gene expression. Attempts to suppress expression of genes on high-copy plasmids often results in residual or “leaky” production of protein. For stringent regulation of gene expression, it is often necessary to excise the gene of interest and subclone it into a low-copy plasmid...

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Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia

Barbara Porton, William C. Wetsel

Schizophrenia Research > 2007 > 94 > 1-3 > 366-370

We analyzed the expression of a presynaptic protein, synapsin III, in individuals with schizophrenia. Since levels of synapsin III were previously found to be significantly reduced in the hippocampus of individuals with schizophrenia, we examined another brain region believed to be a major locus of dysfunction in schizophrenia, the dorsolateral prefrontal cortex (DLPFC). Western blot analyses using...

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Protein expression profiling of postmortem brain in schizophrenia

Jianfeng Mei, Daniel Kolbin, Hung-Teh Kao, Barbara Porton

Schizophrenia Research > 2006 > 84 > 2-3 > 204-213

Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) enables the sensitive, high-throughput protein profiling of complex biological mixtures. In combination with bioinformatics, this technology has the potential to identify combinations of spectral peaks that can differentiate individuals with a particular disease from normal controls. SELDI-TOF-MS was used...

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A rare polymorphism affects a Mitogen-Activated Protein kinase site in synapsin III: possible relationship to schizophrenia

Barbara Porton, Adriana Ferreira, Lynn E. DeLisi, Hung-Teh Kao

Biological Psychiatry > 2004 > 55 > 2 > 118-125

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Brain specific proteins binding to the 3′ UTR of the 5-HT2C receptor mRNA

Hung-Teh Kao, Sherine Ghafoori, Barbara Porton, Dona L Wong, more

Molecular Brain Research > 1996 > 43 > 1-2 > 174-184

The 5-HT _2C receptor2 The abbreviations used are: 5-HT, 5-hydroxytryptamine; UTR, untranslated region; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; K _d , dissociation constant; and IC ₅₀ , concentration of competitor required to inhibit binding by 50%. The following symbols are used for degenerate bases: K for guanine (G) and uridine (U); W for adenosine...

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Search results for: Barbara Porton

Synapsins regulate brain‐derived neurotrophic factor‐mediated synaptic potentiation and axon elongation by acting on membrane rafts

5.2 ASSOCIATION BETWEEN MOLECULAR MARKERS OF NEUROENDOCRINE FUNCTION AND CELLULAR METABOLISM WITH EARLY LIFE STRESS AND PSYCHOPATHOLOGY

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults

Synapsin III: Role in neuronal plasticity and disease

In Response to “No Correlation Between Childhood Maltreatment and Telomere Length”

Childhood Maltreatment and Telomere Shortening: Preliminary Support for an Effect of Early Stress on Cellular Aging

Telomerase levels in schizophrenia: A preliminary study

Strict regulation of gene expression from a high-copy plasmid utilizing a dual vector system

Reduction of synapsin III in the prefrontal cortex of individuals with schizophrenia

Protein expression profiling of postmortem brain in schizophrenia

A rare polymorphism affects a Mitogen-Activated Protein kinase site in synapsin III: possible relationship to schizophrenia

Brain specific proteins binding to the 3′ UTR of the 5-HT2C receptor mRNA

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