Search results for: Brian Ciruna

Items from 1 to 13 out of 13 results

article

UGDH germline loss-of-function mutations cause epilepsy and global developmental delay

Célia Bosso-Lefèvre, Emily Yu, George Grady, Emmanuelle Szenker, more

Mechanisms of Development > 2017 > 145 > S > S26-S27

article

Linking cilia motility and cerebrospinal fluid flow to the etiopathogenesis of idiopathic scoliosis

Daniel Grimes, Curtis Boswell, Nicholas Morante, Mark Henkelman, more

Mechanisms of Development > 2017 > 145 > S > S30

article

Zebrafish models of non‐canonical Wnt/planar cell polarity signalling: fishing for valuable insight into vertebrate polarized cell behavior

Maria Jussila, Brian Ciruna

Wiley Interdisciplinary Reviews: Developmental Biology > 6 > 3 > n/a - n/a

Planar cell polarity (PCP) coordinates the uniform orientation, structure and movement of cells within the plane of a tissue or organ system. It is beautifully illustrated in the polarized arrangement of bristles and hairs that project from specialized cell surfaces of the insect abdomen and wings, and pioneering genetic studies using the fruit fly, Drosophila melanogaster, have defined a core signalling...

article

Cover Image, Volume 6, Issue 3

Maria Jussila, Brian Ciruna

Wiley Interdisciplinary Reviews: Developmental Biology > 6 > 3 > n/a - n/a

The cover image, by Maria Jussila and Brian Ciruna, is based on the Focus Article Zebrafish models of non‐canonical Wnt/planar cell polarity signalling: fishing for valuable insight into vertebrate polarized cell behavior, DOI: 10.1002/wdev.267.

article

Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought

Curtis W. Boswell, Brian Ciruna

Trends in Genetics > 2017 > 33 > 3 > 183-196

IS is a highly prevalent spinal deformity that afflicts upwards of 4% of the population, yet the underlying causes of this disease are unknown.Population-based association studies and next-generation sequencing approaches have identified numerous disease-associated genetic loci; however, a lack of appropriate animal models has hindered understanding of the biological origins of disease.Fish demonstrate...

article

Anisotropy Imaging of Apollo-NADP+ In Vivo to Track NADPH Dynamics in the Pancreatic Beta Cells of Living Zebrafish

Cindy V. Bui, Curtis W. Boswell, Christopher M. McFaul, Christopher M. Yip, more

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 288a

article

Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left–right asymmetry

Simone Superina, Antonia Borovina, Brian Ciruna

Developmental Biology > 2014 > 387 > 2 > 154-166

Growth factors and morphogens regulate embryonic patterning, cell fate specification, cell migration, and morphogenesis. The activity and behavior of these signaling molecules are regulated in the extracellular space through interactions with proteoglycans (Bernfield et al., 1999; Perrimon and Bernfield 2000; Lander and Selleck 2000; Selleck 2000). Proteoglycans are high molecular-weight proteins...

article

IFT88 Plays a Cilia- and PCP-Independent Role in Controlling Oriented Cell Divisions during Vertebrate Embryonic Development

Antonia Borovina, Brian Ciruna

Cell Reports > 2013 > 5 > 1 > 37-43

The role for cilia in establishing planar cell polarity (PCP) is contentious. Although knockdown of genes known to function in ciliogenesis has been reported to cause PCP-related morphogenesis defects in zebrafish, genetic mutations affecting intraflagellar transport (IFT) do not show PCP phenotypes despite the requirement for IFT in cilia formation. This discrepancy has been attributed to off-target...

chapter

Automated batch transfer of zebrafish embryos using a multi-degrees-of-freedom system

Xuping Zhang, Zhe Lu, Danielle Gelinas, Brian Ciruna, more

2011 IEEE International Conference on Robotics and Automation > 2554 - 2559

2011 IEEE International Conference on Robotics and Automation (ICRA)

Biological experiments and drug screen require the transfer of individual zebrafish embryos into standard multi-well microplates. Manually pipetting embryos into wells is tedious and time consuming. This paper reports a prototype cooperative robotic system capable of transferring zebrafish embryos in parallel and depositing a single embryo per well in a 96-well microplate. A cell holding device was...

article

Batch Transfer of Zebrafish Embryos Into Multiwell Plates

Xuping Zhang, Zhe Lu, Danielle Gelinas, Brian Ciruna, more

IEEE Transactions on Automation Science and Engineering > 2011 > 8 > 3 > 625 - 632

This paper reports a prototype cooperative robotic system capable of transferring zebrafish embryos in parallel and depositing a single embryo per well in a 96-well microplate. A cell holding device was developed to trap multiple embryos in a regular pattern. The cell holding device and a microplate were positioned and aligned along multiple axes by the system. Embryo release strategies were systematically...

article

Regulation of Vertebrate Nervous System Alternative Splicing and Development by an SR-Related Protein

John A. Calarco, Simone Superina, Dave O'Hanlon, Mathieu Gabut, more

Cell > 2009 > 138 > 5 > 898-910

Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a genome-wide computational and expression profiling strategy, we have identified a tissue- and vertebrate-restricted...

article

Investigating the relationship between PCP and ciliogenesis

Antonia Borovina, Brian Ciruna

Developmental Biology > 2009 > 331 > 2 > 425-426

article

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

Brian Ciruna, Janet Rossant

Developmental Cell > 2001 > 1 > 1 > 37-49

Although FGF signaling plays an integral role in the migration and patterning of mesoderm at gastrulation, the mechanism and downstream targets of FGF activity have remained elusive. Here, we demonstrate that FGFR1 orchestrates the epithelial to mesenchymal transition and morphogenesis of mesoderm at the primitive streak by controlling Snail and E-cadherin expression. Furthermore, we show that FGFR1...

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