Search results for: Davide Cervia

Items from 1 to 19 out of 19 results

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An update on the assessment and management of metabolic syndrome, a growing medical emergency in paediatric populations

Chiara Mameli, Gian Vincenzo Zuccotti, Carla Carnovale, Erica Galli, more

Pharmacological Research > 2017 > 119 > C > 99-117

In the last decades the increasing rate of obesity in children and adolescents worldwide has led to the onset in paediatric age of metabolic syndrome, a disease commonly associated to adulthood.Central obesity, dyslipidaemia, hyperglycaemia, and hypertension are typical features of metabolic syndrome that seem to hesitate often in type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver...

article

Reversal of Defective Mitochondrial Biogenesis in Limb-Girdle Muscular Dystrophy 2D by Independent Modulation of Histone and PGC-1α Acetylation

Sarah Pambianco, Matteo Giovarelli, Cristiana Perrotta, Silvia Zecchini, more

Cell Reports > 2016 > 17 > 11 > 3010-3023

Mitochondrial dysfunction occurs in many muscle degenerative disorders. Here, we demonstrate that mitochondrial biogenesis was impaired in limb-girdle muscular dystrophy (LGMD) 2D patients and mice and was associated with impaired OxPhos capacity. Two distinct approaches that modulated histones or peroxisome proliferator-activated receptor-gamma coactivator 1 α (PGC-1α) acetylation exerted equivalent...

article

Natural products from aquatic eukaryotic microorganisms for cancer therapy: Perspectives on anti-tumour properties of ciliate bioactive molecules

Elisabetta Catalani, Francesca Proietti Serafini, Silvia Zecchini, Simona Picchietti, more

Pharmacological Research > 2016 > 113 > PA > 409-420

Several modern drugs, including those for cancer therapy, have been isolated from natural sources, are based on natural products and its derivatives, or mime natural products. Some of them are in clinical use, others in clinical trials. The success of natural products in drug discovery is related to their biochemical characteristics and to the technologic methods used to study their feature. Natural...

article

The emerging role of Acid Sphingomyelinase in autophagy

Cristiana Perrotta, Davide Cervia, Clara Palma, Emma Assi, more

Apoptosis > 2015 > 20 > 5 > 635-644

Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase (A-SMase), already known to play a fundamental...

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Nitric oxide drives embryonic myogenesis in chicken through the upregulation of myogenic differentiation factors

Denise Cazzato, Emma Assi, Claudia Moscheni, Silvia Brunelli, more

Experimental Cell Research > 2014 > 320 > 2 > 269-280

The muscle-specific variant of neuronal nitric oxide (NO) synthase (NOS-I), is developmentally regulated in mouse suggesting a role of NO during myogenesis. In chick embryo, a good model of development, we found that the expression of NOS-I is up-regulated, but only in the early phase of development. Through a pharmacological intervention in ovo we found that NO signalling plays a relevant role during...

article

Protective Role during Inflammation

Cristiana Perrotta, Marcella Buldorini, Emma Assi, Denise Cazzato, more

The American Journal of Pathology > 2014 > 184 > 1 > 230-247

The endocrine system participates in regulating macrophage maturation, although little is known about the modulating role of the thyroid hormones. In vitro results demonstrate a negative role of one such hormone, triiodothyronine (T ₃ ), in triggering the differentiation of bone marrow–derived monocytes into unpolarized macrophages. T ₃ -induced macrophages displayed a classically...

article

The protein pheromone Er-1 of the ciliate Euplotes raikovi stimulates human T-cell activity: Involvement of interleukin-2 system

Davide Cervia, Elisabetta Catalani, Maria Cristina Belardinelli, Cristiana Perrotta, more

Experimental Cell Research > 2013 > 319 > 3 > 56-67

Water-soluble protein signals (pheromones) of the ciliate Euplotes have been supposed to be functional precursors of growth factors and cytokines that regulate cell–cell interaction in multi-cellular eukaryotes. This work provides evidence that native preparations of the Euplotes raikovi pheromone Er-1 (a helical protein of 40 amino acids) specifically increases viability, DNA synthesis, proliferation,...

article

Vascular endothelial growth factor in the ischemic retina and its regulation by somatostatin

Davide Cervia, Elisabetta Catalani, Massimo Dal Monte, Giovanni Casini

Journal of Neurochemistry > 120 > 5 > 818 - 829

J. Neurochem. (2012) 120, 818–829. AbstractIn a retinal ischemic ex vivo model, we have reported protective effects of somatostatin (SRIF) receptor 2 (sst₂). As an ischemic condition not only causes cell death but also induces a vascular response, we asked whether vascular endothelial growth factor (VEGF) is altered in this model and whether its expression, release or localization are affected by...

article

Divergences in the Response to Ultraviolet Radiation Between Polar and Non-Polar Ciliated Protozoa

Graziano Di Giuseppe, Davide Cervia, Adriana Vallesi

Microbial Ecology > 2012 > 63 > 2 > 334-338

Ultraviolet (UV) radiation has detrimental effects on marine ecosystems, in particular in the polar regions where stratospheric ozone reduction causes higher levels of solar radiation. We analyzed two polar species of Euplotes, Euplotes focardii and Euplotes nobilii, for the sensitivity to UV radiation in comparison with two akin species from mid-latitude and tropical waters. Results showed that they...

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Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain

Silvia Alboni, Davide Cervia, Brendon Ross, Claudia Montanari, more

Journal of Neuroimmunology > 2009 > 214 > 1-2 > 43-54

The cytokine IL-18 acts on the CNS both in physiological and pathological conditions. Its action occurs through the heterodimeric receptor IL-18Rα\β. To better understand IL-18 central effects, we investigated in the mouse brain the distribution of two IL-18Rα transcripts, a full length and an isoform lacking the intracellular domain hypothesized to be a decoy receptor. Both isoforms were expressed...

article

Physiology and pathology of somatostatin in the mammalian retina: A current view

Davide Cervia, Giovanni Casini, Paola Bagnoli

Molecular and Cellular Endocrinology > 2008 > 286 > 1-2 > 112-122

In the retina, peptidergic signalling participates in multiple circuits of visual information processing. The neuropeptide somatostatin (SRIF) is localised to amacrine cells and, in some instances, in a subset of ganglion cells. The variegated expression patterns of SRIF receptors (sst ₁ –sst ₅ ) and the variety of signalling mechanisms activated by retinal SRIF suggest that this peptide...

article

The cyclooxygenase-2/prostaglandin E2 pathway is involved in the somatostatin-induced decrease of epileptiform bursting in the mouse hippocampus

Chiara Ristori, Maurizio Cammalleri, Davide Martini, Barbara Pavan, more

Neuropharmacology > 2008 > 54 > 5 > 874-884

The neuromodulatory peptide somatostatin-14 (SRIF) plays an important inhibitory role in epilepsy, but little is known on the signalling mechanisms coupled to this effect of SRIF. We have previously demonstrated that SRIF induces reduction of epileptiform bursting in a model of interictal-like activity in mouse hippocampal slices. In this same model, we investigated whether the cyclooxygenase 2 (COX-2)/prostaglandin...

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An update on somatostatin receptor signaling in native systems and new insights on their pathophysiology

Davide Cervia, Paola Bagnoli

Pharmacology and Therapeutics > 2007 > 116 > 2 > 322-341

The peptide somatostatin (SRIF) has important physiological effects, mostly inhibitory, which have formed the basis for the clinical use of SRIF compounds. SRIF binding to its 5 guanine nucleotide-binding proteins-coupled receptors leads to the modulation of multiple transduction pathways. However, our current understanding of signaling exerted by receptors endogenously expressed in different cells/tissues...

article

Molecular mechanisms of euplotin C-induced apoptosis: involvement of mitochondrial dysfunction, oxidative stress and proteases

Davide Cervia, Mercedes Garcia-Gil, Elisa Simonetti, Graziano Giuseppe, more

Apoptosis > 2007 > 12 > 8 > 1349-1363

The metabolite euplotin C (EC), isolated from the marine ciliate Euplotes crassus, is a powerful cytotoxic and pro-apoptotic agent in tumour cell lines. For instance, EC induces the rapid depletion of ryanodine Ca²⁺ stores, the release of cytochrome c from the mitochondria, and the activation of caspase-3, leading to apoptosis. The purpose of this study was to gain further insight into the mechanisms...

article

Binding and functional properties of the novel somatostatin analogue KE 108 at native mouse somatostatin receptors

Davide Cervia, Daniel Langenegger, Edi Schuepbach, Maurizio Cammalleri, more

Neuropharmacology > 2005 > 48 > 6 > 881-893

Clinically used somatostatin (SRIF) analogs, octreotide and lanreotide, act primarily by binding to SRIF receptor subtype 2 (sst ₂ ). In contrast, the recently described multiligand SOM230 binds with high affinity to sst _1–3 and sst ₅ and KE 108 is characterised as a high affinity ligand for all five SRIF receptors. In tumoural mouse corticotrophs (AtT-20 cells) and in mouse...

article

Somatostatin coupling to adenylyl cyclase activity in the mouse retina

Barbara Pavan, Sara Fiorini, Massimo Dal Monte, Laura Lunghi, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2004 > 370 > 2 > 91-98

The peptide somatostatin-14 (SRIF) acts in the mammalian retina through its distinct receptors (sst15). Scarce information is available on SRIF function in the retina, including the elucidation of transduction pathways mediating SRIF action. We have investigated SRIF and SRIF receptor modulation of adenylyl cyclase (AC) activity in both wild-type (WT) retinas and sst1 or sst2 knock-out (KO) retinas,...

article

Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina

Massimo Dal Monte, Cristina Petrucci, Anna Vasilaki, Davide Cervia, more

Neuropharmacology > 2003 > 45 > 8 > 1080-1092

In the mammalian retina, sparse amacrine cells contain somatostatin-14 (SRIF) which acts at multiple levels of neuronal circuitry through distinct SRIF receptors (sst ₁ _- ₅ ). Among them, the sst ₁ receptor has been localised to SRIF-containing amacrine cells in the rat and rabbit retina. Little is known about sst ₁ receptor localisation and function in the mouse retina...

article

Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs

Davide Cervia, Dominique Fehlmann, Daniel Hoyer

Naunyn-Schmiedeberg's Archives of Pharmacology > 2003 > 367 > 6 > 578-587

Of the five cloned somatostatin (SRIF: somatotropin release inhibitory factor) receptors (sst15), only sst2 and sst5 receptors appear to be endogenously expressed and functionally active in AtT-20 mouse anterior pituitary tumour cells. In this study, the presence and the functional coupling of SRIF receptors to G-protein in AtT-20 cells was evaluated by receptor autoradiography and guanosine-5--(3-[35S]thio)-triphosphate...

article

Somatostatin (SRIF) modulates distinct signaling pathways in rat pituitary tumor cells; negative coupling of SRIF receptor subtypes 1 and 2 to arachidonic acid release

Davide Cervia, Sara Fiorini, Barbara Pavan, Carla Biondi, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2002 > 365 > 3 > 200-209

Abstract. The somatotropin release-inhibiting factor somatostatin-14 (SRIF) is known to activate distinct receptor subtypes (sst15). In rat pituitary tumor cells (GC cells), sst2 but not sst1 receptors mediate the SRIF-induced inhibition of intracellular concentration of Ca2+ ([Ca2+]i) and are negatively coupled to cAMP-dependent pathways. In the present study, transduction mechanisms coupling distinct...

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