Search results for: Jadwiga Jodynis-Liebert

Items from 1 to 20 out of 22 results

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Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Agnieszka Klupczynska, Anna Maria Sulej-Suchomska, Hanna Piotrowska-Kempisty, Marcin Wierzchowski, more

Journal of Chromatography B > 2017 > 1060 > C > 30-35

The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determination...

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Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

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Evaluation of Safety of Iron-Fortified Soybean Sprouts, a Potential Component of Functional Food, in Rat

Małgorzata Kujawska, Małgorzata Ewertowska, Ewa Ignatowicz, Teresa Adamska, more

Plant Foods for Human Nutrition > 2016 > 71 > 1 > 13-18

Ferritin-iron is currently considered as one of the most promising iron forms to prevent iron deficiency anaemia. We found that the cultivation of soybean seeds in a solution of ferrous sulfate results in material with extremely high iron content - 560.6 mg Fe/100 g of dry matter, while ferritin iron content was 420.5 mg/100 g dry matter. To assess the potential adverse effects of a preparation containing...

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DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer

Hanna Piotrowska, Krzysztof Myszkowski, Joanna Abraszek, Eliza Kwiatkowska-Borowczyk, more

Biomedicine & Pharmacotherapy > 2014 > 68 > 4 > 397-400

DMU-212 has been shown to evoke a mitochondrial apoptotic pathway in transformed fibroblasts and breast cancer. However, recently published data indicated the ability of DMU-212 to evoke apoptosis in both mitochondria- and receptor-mediated manner in two ovarian cancer cell lines, namely A-2780 and SKOV-3, which showed varied sensitivity to the compound tested. The pronounced cytotoxic effects of...

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Antioxidant effect of lycopene-enriched tomato paste on N-nitrosodiethylamine-induced oxidative stress in rats

Malgorzata Kujawska, Malgorzata Ewertowska, Teresa Adamska, Czeslaw Sadowski, more

Journal of Physiology and Biochemistry > 2014 > 70 > 4 > 981-990

Lycopene is a carotenoid pigment produced by vegetables and fruits, with tomatoes and their processed products being the most abundant sources. A high number of conjugated dienes make lycopene a powerful radical scavenger. Its antioxidant properties are considered to be primarily involved in many beneficial health effects. The present study was designed to assess the protective effect of lycopene-enriched...

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3,4,5,4′-trans-tetramethoxystilbene (DMU-212) modulates the activation of NF-κB, AP-1, and STAT3 transcription factors in rat liver carcinogenesis induced by initiation-promotion regimen

Michał Cichocki, Wanda Baer-Dubowska, Marcin Wierzchowski, Marek Murias, more

Molecular and Cellular Biochemistry > 2014 > 391 > 1-2 > 27-35

It has been reported that methylated analog of resveratrol, 3,4,5,4′-trans-tetramethoxystilbene (DMU-212), demonstrates strong antiproliferative, and proapoptotic activity. The aim of this study was to evaluate the effect of DMU-212 on the activation of nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducer and activator of transcription 3 (STAT3) transcription factors, using...

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Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue

Hanna Piotrowska, Krzysztof Myszkowski, Ryszard Amarowicz, Marek Murias, more

Toxicology in Vitro > 2013 > 27 > 8 > 2127-2134

The cytotoxic activity of DMU-212 has been shown to vary in cell lines derived from the same type of cancer, i.e. ovarian, breast and colorectal ones. However, the molecular mechanism of DMU-212 cytotoxicity has not been clarified in colon cancer cells. This study aims to elucidate the mechanism of antitumor effects of DMU-212 in two human colon cancer cell lines, DLD-1 and LOVO. We showed the stronger...

article

Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

Marcin Ozarowski, Przemyslaw L. Mikolajczak, Anna Bogacz, Agnieszka Gryszczynska, more

Fitoterapia > 2013 > 91 > C > 261-271

Rosmarinus officinalis L. leaf as part of a diet and medication can be a valuable proposal for the prevention and treatment of dementia. The aim of the study was to assess the effects of subchronic (28-fold) administration of a plant extract (RE) (200mg/kg, p.o.) on behavioral and cognitive responses of rats linked with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity and their...

article

Attenuation of KBrO₃‐Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat

Małgorzata Kujawska, Ewa Ignatowicz, Małgorzata Ewertowska, Teresa Adamska, more

Phytotherapy Research > 27 > 8 > 1214 - 1219

The aim of the study was to evaluate a protective effect of apple juice on KBrO₃‐induced oxidative stress in rats. Male Wistar rats were administered apple juice per os, 10 ml/kg b.w. for 28 days. On 27 day of the experiment, some rats were given i.p. a single 125 mg/kg b.w. dose of KBrO₃. Markers of oxidative damage and clinical chemistry parameters were determined. Treatment with apple juice prior...

article

Resveratrol analogue 3,4,4′,5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV‐3 and A-2780 cancer cells

Hanna Piotrowska, Krzysztof Myszkowski, Alicja Ziółkowska, Katarzyna Kulcenty, more

Toxicology and Applied Pharmacology > 2012 > 263 > 1 > 53-60

In the screening studies, cytotoxicity of 12 methylated resveratrol analogues on 11 human cancer cell lines was examined. The most active compound 3,4,4′5-tetramethoxystilbene (DMU-212) and two ovarian cancer cell lines A-2780 (IC ₅₀ =0.71μM) and SKOV-3 (IC ₅₀ =11.51μM) were selected for further investigation.To determine the mechanism of DMU-212 cytotoxicity, its ability to induce...

article

Cloudy apple juice protects against chemical-induced oxidative stress in rat

Małgorzata Kujawska, Ewa Ignatowicz, Małgorzata Ewertowska, Jarosław Markowski, more

European Journal of Nutrition > 2011 > 50 > 1 > 53-60

Background Apples abundant in phenolic compounds show a variety of biological activities that may contribute to beneficial effects against some chronic diseases. Purpose The aim of our study was to assess the protective effect of cloudy apple juice against chemical-induced oxidative stress in rats. Methods Male Wistar rats were treated with apple juice per os, 10 mL/kg/day for 28 days and with...

article

Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats

Jadwiga Jodynis-Liebert, Michal Nowicki, Marek Murias, Teresa Adamska, more

Regulatory Toxicology and Pharmacology > 2010 > 57 > 2-3 > 266-273

The aim of this study was to investigate cytotoxicity, acute and subchronic oral toxicity of an ionic liquid didecyldimethylammonium saccharinate [DDA][Sac] in rat.IC ₅₀ values tested on six human cell lines varied from 1.44μM to 5.47μM. The compound tested was classified to the 4th toxicity class with a fixed LD ₅₀ cut-off value 500mg/kg. Organ pathology induced by [DDA][Sac] in an...

article

Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats

Jadwiga Jodynis-Liebert, Teresa Adamska, Małgorzata Ewertowska, Wiesława Bylka, more

Experimental and Toxicologic Pathology > 2009 > 61 > 5 > 443-451

Six groups of male Wistar rats were treated as follows: in groups II, III and V liver damage was induced by CCl ₄ (per os, 1590mg/kgb.w.day) given 2 days a week for 6 weeks; group III was treated simultaneously with ethanol extract of Aquilegia vulgaris (100mg/kgb.w.day) for 6 weeks; group V with silymarin, positive control, at a dose of 100mg/kgb.w.day for 6 weeks; and groups IV and VI received...

article

Protective Effect of Red Beetroot against Carbon Tetrachloride- and N -Nitrosodiethylamine-Induced Oxidative Stress in Rats

Małgorzata Kujawska, Ewa Ignatowicz, Marek Murias, Małgorzata Ewertowska, more

Journal of Agricultural and Food Chemistry > 2009 > 57 > 6 > 2570 - 2575

article

Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase

Marek Murias, Michal W. Luczak, Anna Niepsuj, Violetta Krajka-Kuzniak, more

Toxicology in Vitro > 2008 > 22 > 5 > 1361-1370

The phytochemical resveratrol, which is found in grapes and red wine, has been reported to have a variety of biological properties. It was shown in our previous research that introduction of additional hydroxyl groups into the stilbene structure increases the biological activity of resveratrol. In this study, the activity of 3,3′,4,4′,5,5′-hexahydroxystilbene (M8) was investigated in ZR-75-1, MDA-MB-231...

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In vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes

Lukasz Kedzierski, Joan M. Curtis, Milena Kaminska, Jadwiga Jodynis-Liebert, more

Parasitology Research > 2007 > 102 > 1 > 91-97

Resveratrol, a natural phytoalexin found mainly in grapes, possesses a variety of beneficial activities including anticancer, antimicrobial and antiviral. However, there is no information about its effects on kinetoplastid parasites such as Leishmania. Leishmania is a human pathogen responsible for a spectrum of diseases known as leishmaniases and a significant health problem in many parts of the...

article

Protective effect of Aquilegia vulgaris L. on aflatoxin B1-induced hepatic damage in rats

Jadwiga Jodynis-Liebert, Irena Matławska, Wiesława Bylka, Marek Murias

Environmental Toxicology and Pharmacology > 2006 > 22 > 1 > 58-63

The aim of the study was to investigate the effect of ethanol and ethyl acetate extract obtained from Aquilegia vulgaris L. on microsomal lipid peroxidation, reduced glutathione level and antioxidant enzymes activity in the liver of rats intoxicated with aflatoxin B ₁ (AFB ₁ ). Animals were pretreated with 12 daily p.o. doses of the extracts tested (100mg/kg body weight). Then AFB...

article

Effect of multiple freeze–thaw cycles of cytoplasm samples on the activity of antioxidant enzymes

Marek Murias, Magdalena Rachtan, Jadwiga Jodynis-Liebert

Journal of Pharmacological and Toxicological Methods > 2005 > 52 > 2 > 302-305

In this paper the activity of cytoplasmatic antioxidant enzymes after multiple freeze–thaw cycles of samples of cytoplasm was assayed in order to characterise the limits that would be necessary to impose on experimental design.The activities of antioxidant enzymes in samples of rat liver cytoplasm were evaluated after 1, 2, 3, 4, 5, 10 and 15 freeze–thaw cycles. The activity of antioxidant enzymes...

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Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris

Marek Murias, Jadwiga Jodynis-Liebert, Irena Matławska, Wiesława Bylka

Fitoterapia > 2005 > 76 > 5 > 476-480

Two extracts (ethyl acetate and ethanol) and isocytisoside obtained from Aquilegia vulgaris were tested for their antioxidant and free radical scavenging activity in vitro. Inhibition both non-enzymatic (IC ₅₀ : 150–219 μg/ml) and enzymatic (IC ₅₀ : 23–60 μg/ml) microsomal lipid peroxidation was observed, the extracts being more active than isocytisoside. The substances tested appeared...

article

Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats

Jadwiga Jodynis-Liebert, Irena Matławska, Wiesława Bylka, Marek Murias

Journal of Ethnopharmacology > 2005 > 97 > 2 > 351-358

Rats pretreated with acetaminophen (N-acetyl-p-aminophenol, APAP) (600mg/kg b.w., p.o.) were administered with ethanol and ethyl acetate extracts as well as with isocytisoside (100mg/kg b.w., p.o.) obtained from Aquilegia vulgaris (L.) (Ranunculaceae) herb. The substances tested decreased enzymatic, non-enzymatic and uninduced microsomal lipid peroxidation (LPO) in the liver of rats treated with APAP...

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Search results for: Jadwiga Jodynis-Liebert

Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Evaluation of Safety of Iron-Fortified Soybean Sprouts, a Potential Component of Functional Food, in Rat

DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer

Antioxidant effect of lycopene-enriched tomato paste on N-nitrosodiethylamine-induced oxidative stress in rats

3,4,5,4′-trans-tetramethoxystilbene (DMU-212) modulates the activation of NF-κB, AP-1, and STAT3 transcription factors in rat liver carcinogenesis induced by initiation-promotion regimen

Different susceptibility of colon cancer DLD-1 and LOVO cell lines to apoptosis induced by DMU-212, a synthetic resveratrol analogue

Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

Attenuation of KBrO₃‐Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat

Resveratrol analogue 3,4,4′,5-tetramethoxystilbene inhibits growth, arrests cell cycle and induces apoptosis in ovarian SKOV‐3 and A-2780 cancer cells

Cloudy apple juice protects against chemical-induced oxidative stress in rat

Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats

Aquilegia vulgaris extract attenuates carbon tetrachloride-induced liver fibrosis in rats

Protective Effect of Red Beetroot against Carbon Tetrachloride- and N -Nitrosodiethylamine-Induced Oxidative Stress in Rats

Cytotoxic activity of 3,3′,4,4′,5,5′-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase

In vitro antileishmanial activity of resveratrol and its hydroxylated analogues against Leishmania major promastigotes and amastigotes

Protective effect of Aquilegia vulgaris L. on aflatoxin B1-induced hepatic damage in rats

Effect of multiple freeze–thaw cycles of cytoplasm samples on the activity of antioxidant enzymes

Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris

Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats

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