Search results for: Krisztina Pálóczi

Items from 1 to 11 out of 11 results

article

Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells

Hargita Hegyesi, Nikolett Sándor, Géza Sáfrány, Virág Lovas, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-12

Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the incidence of breast cancer continues to rise, radiotherapy has emerged as a leading...

article

Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors

Zsuzsanna Szvicsek, Ádám Oszvald, Lili Szabó, Gyöngyvér Orsolya Sándor, more

Cellular and Molecular Life Sciences > 2019 > 76 > 12 > 2463-2476

Extracellular vesicles (EVs) are membrane-surrounded structures that transmit biologically important molecules from the releasing to target cells, thus providing a novel intercellular communication mechanism. Since EVs carry their cargo in a protected form and their secretion is generally increased in tumorigenesis, EVs hold a great potential for early cancer diagnosis. By 3D culturing, we provide...

article

Mesenteric lymph node stromal cell‐derived extracellular vesicles contribute to peripheral de novo induction of Foxp3⁺ regulatory T cells

Maria Pasztoi, Joern Pezoldt, Michael Beckstette, Christoph Lipps, more

European Journal of Immunology > 47 > 12 > 2142 - 2152

Intestinal regulatory T cells (Tregs) are fundamental in peripheral tolerance toward commensals and food‐borne antigens. Accordingly, gut‐draining mesenteric lymph nodes (mLNs) represent a site of efficient peripheral de novo Treg induction when compared to skin‐draining peripheral LNs (pLNs), and we had recently shown that LN stromal cells substantially contribute to this process. Here, we aimed...

article

Oxidative and other posttranslational modifications in extracellular vesicle biology

Katalin Szabó-Taylor, Brent Ryan, Xabier Osteikoetxea, Tamás G. Szabó, more

Seminars in Cell and Developmental Biology > 2015 > 40 > Complete > 8-16

Extracellular vesicles including exosomes, microvesicles and apoptotic vesicles, are phospholipid bilayer surrounded structures secreted by cells universally, in an evolutionarily conserved fashion. Posttranslational modifications such as oxidation, citrullination, phosphorylation and glycosylation play diverse roles in extracellular vesicle biology. Posttranslational modifications orchestrate the...

article

Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles

Zoltán Giricz, Zoltán V. Varga, Tamás Baranyai, Péter Sipos, more

Journal of Molecular and Cellular Cardiology > 2014 > 68 > Complete > 75-78

Remote ischemic preconditioning (RIPC) of the heart is exerted by brief ischemic insults affected on a remote organ or a remote area of the heart before a sustained cardiac ischemia. To date, little is known about the inter-organ transfer mechanisms of cardioprotection by RIPC. Exosomes and microvesicles/microparticles are vesicles of 30–100nm and 100–1000nm in diameter, respectively (collectively...

article

Improved circulating microparticle analysis in acid-citrate dextrose (ACD) anticoagulant tube

Bence György, Krisztina Pálóczi, Alexandra Kovács, Eszter Barabás, more

Thrombosis Research > 2014 > 133 > 2 > 285-292

Recently extracellular vesicles (exosomes, microparticles also referred to as microvesicles and apoptotic bodies) have attracted substantial interest as potential biomarkers and therapeutic vehicles. However, analysis of microparticles in biological fluids is confounded by many factors such as the activation of cells in the blood collection tube that leads to in vitro vesiculation. In this study we...

article

Critical role of extracellular vesicles in modulating the cellular effects of cytokines

Géza Tamás Szabó, Bettina Tarr, Krisztina Pálóczi, Katalin Éder, more

Cellular and Molecular Life Sciences > 2014 > 71 > 20 > 4055-4067

Under physiological and pathological conditions, extracellular vesicles (EVs) are present in the extracellular compartment simultaneously with soluble mediators. We hypothesized that cytokine effects may be modulated by EVs, the recently recognized conveyors of intercellular messages. In order to test this hypothesis, human monocyte cells were incubated with CCRF acute lymphoblastic leukemia cell...

article

The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis

Petra Misják, Szilvia Bősze, Kata Horváti, Mária Pásztói, more

Immunology Letters > 2013 > 152 > 1 > 25-31

The P70-84 peptide (also called 5/4E8 epitope) of the human cartilage proteoglycan (PG) aggrecan is the dominant/arthritogenic epitope in both humans and arthritis-prone BALB/c mice (PG-induced arthritis, PGIA). An elevated T cell reactivity was demonstrated to a citrullinated version of the P70-84 epitope in most of the patients with rheumatoid arthritis (RA). The goal of this study was to understand...

article

The recently identified hexosaminidase D enzyme substantially contributes to the elevated hexosaminidase activity in rheumatoid arthritis

Mária Pásztói, Barbara Sódar, Petra Misják, Krisztina Pálóczi, more

Immunology Letters > 2013 > 149 > 1-2 > 71-76

Since the 1970s, numerous reports have described elevated hexosaminidase activities in rheumatoid arthritis. However, due to the overlapping substrate specificities of different hexosaminidases, identification of the exact enzyme(s) responsible for the elevated activity remains incomplete.In this work we tested if the recently described enzyme, hexosaminidase D was expressed in human arthritic joints,...

article

Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice

Lilla Turiák, Petra Misják, Tamás G. Szabó, Borbála Aradi, more

Journal of Proteomics > 2011 > 74 > 10 > 2025-2033

Several studies have characterized exosomes derived from different cell sources. In this work we set the goal of proteomic characterization of two less studied populations of membrane vesicles, microvesicles (100–800nm) and apoptotic bodies (>800nm) released by thymus cells of BALB/c mice. The vesicles were isolated by the combination of differential centrifugation and gravity driven multistep...

article

A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis

Zsuzsanna Pál, Péter Antal, András Millinghoffer, Gábor Hullám, more

Journal of Neuroimmunology > 2010 > 229 > 1-2 > 107-111

Galectin-1 (LGALS1) and interleukin receptor 2β (IL2Rβ) are regulators of T-cell activation. Here we evaluated the association of regulatory region polymorphisms of the LGALS1 (rs4820293, rs4820294) and IL2Rβ (rs743777, rs228941) genes in 146 Caucasian myasthenia gravis patients compared to 291 ethnically matched controls. A significant difference was found in the distribution of the rs4820293/rs743777...

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Search results for: Krisztina Pálóczi

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