Search results for: M. Ullmann

Items from 1 to 20 out of 35 results

article

Risk factors for venous thromboembolism (VTE) after adrenalectomy for adrenal cortical neoplasms

Maureen D. Moore, Christopher Agrusa, Timothy M. Ullmann, Toni Beninato, more

Journal of Surgical Oncology > 126 > 7 > 1176 - 1182

Background Incidence of venous thromboembolism (VTE) after adrenalectomy for adrenal cortical carcinoma (ACC) is unknown. Herein, we aim to identify the relative incidence and risk factors of VTE after adrenalectomy for ACC. Methods The American College of Surgeons National Surgical Quality Improvement Program database was queried to identify patients who underwent adrenalectomy for ACC, Cushing...

article

AURIEL‐PsO: a randomized, double‐blind phase III equivalence trial to demonstrate the clinical similarity of the proposed biosimilar MSB11022 to reference adalimumab in patients with moderate‐to‐severe chronic plaque‐type psoriasis

J. Hercogová, K.A. Papp, V. Chyrok, M. Ullmann, more

British Journal of Dermatology > 182 > 2 > 316 - 326

Background MSB11022 is a proposed adalimumab biosimilar. Objectives To compare the efficacy, safety and immunogenicity of MSB11022 with reference adalimumab. Methods AURIEL‐PsO was a double‐blind randomized controlled equivalence trial, in which patients with moderate‐to‐severe chronic plaque‐type psoriasis were randomized 1 : 1 to MSB11022 or reference adalimumab. The primary end point was ≥...

article

CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules

Wei Li, Shujun Xia, Anna Aronova, Irene M. Min, more

Journal of Surgical Oncology > 118 > 6 > 1042 - 1049

Background and Objectives Hürthle cell carcinoma (HCC) is an unusual and relatively rare type of differentiated thyroid cancer. Currently, cytologic analysis of fine‐needle aspiration biopsy is limited in distinguishing benign Hürthle cell neoplasms from malignant ones. The aim of this study was to determine whether differences in the expression of specific genes could differentiate HCC from benign...

article

Robotic Reoperative Anti-reflux Surgery: Low Perioperative Morbidity and High Symptom Resolution

Adham Elmously, Katherine D. Gray, Timothy M. Ullmann, Thomas J. Fahey, more

World Journal of Surgery > 2018 > 42 > 12 > 4014-4021

Background Laparoscopic reoperative anti-reflux surgery (ARS) has a significantly higher morbidity than laparoscopic primary ARS; however, it is not known whether the same pattern exists within the robotic approach. We aimed to evaluate the safety and efficacy of robotic reoperative ARS in comparison with primary robotic ARS. Methods A retrospective review of patients undergoing primary or reoperative...

article

Correction to: Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment

D. Gouty, C. C. Cai, X. Y. Cai, A. Kasinath, more

The AAPS Journal > 2018 > 20 > 2 > 1-1

In the published article, the author B. Babbitt was cited as affiliation 9, but should have been cited as affiliation 2. In addition, there are 2 errors in the affiliations. The correct affiliations are shown in this erratum.

article

An empirical examination of the thickness profile formation of twin-roll-cast magnesium strips

C. Kawalla, M. Höck, M. Ullmann, C. M. Ringle

Archives of Civil and Mechanical Engineering > 2018 > Vol. 18, no. 1 > 227--234

The recently developed technology of twin-roll-cast (TRC) magnesium strips permits an efficient production of magnesium sheets, primarily for the automotive industry. The focus of the paper is to develop a structural equation model explaining the variance of the thickness profile formation. Hence, the complex and partially unknown relationships between twin-roll casting process parameters and the...

article

Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment

D. Gouty, C. C. Cai, X. Y. Cai, A. Kasinath, more

The AAPS Journal > 2018 > 20 > 1 > 1-9

The American Association of Pharmaceutical Scientists (AAPS) biosimilar focus group on nonclinical and clinical assays has developed this manuscript to guide the industry on best practices and testing strategies when developing neutralizing antibody (NAb) assays for biosimilar programs. The immunogenicity assessment to biosimilar and originator drug products is one of the key aspects of clinical programs...

article

Less is More: The Impact of Multidisciplinary Thyroid Conference on the Treatment of Well-Differentiated Thyroid Carcinoma

Maureen D. Moore, Emily Postma, Katherine D. Gray, Timothy M. Ullmann, more

World Journal of Surgery > 2018 > 42 > 2 > 343-349

Background In 2006, a multidisciplinary thyroid conference (MDTC) was implemented to better plan management of thyroid cancer patients at our institution. This study assessed the clinical impact of a MDTC on radioactive iodine (RAI) treatment patterns. Methods A prospective database (2003–2014) collected patient and tumor characteristics, RAI doses, and tumor recurrences. Patients treated with total...

article

Numerical Investigation of the Oxide Scale Deformation Behaviour with Consideration of Carbon Content during Hot Forging

B.-A. Behrens, R. Kawalla, B. Awiszus, A. Bouguecha, more

Procedia Engineering > 2017 > 207 > C > 526-531

Due to increasing product requirements the numerical simulation has become a powerful tool for the effective and efficient design of individual process steps as well as entire process chains. In order to model hot forging processes with finite element based numerical methods realistic models are required which consider the detailed mathematical description of the material behaviour during the forging...

chapter

Scalable Application-Dependent Network on Chip Adaptivity for Dynamical Reconfigurable Real-Time Systems

M. Huebner, M. Ullmann, L. Braun, A. Klausmann, more

Lecture Notes in Computer Science > Field Programmable Logic and Application > Network on Chip and Adaptive Architectures > 1037-1041

Current trends show that in future it will be essential that various kinds of applications are running on one chip. These require an efficient and flexible network on chip which is able to adapt to the demands of supported modules. This makes it necessary to think about what kind of network on chip will meet these requirements. This paper describes an approach for a reconfigurable network on chip...

chapter

Formal Methods Diffusion: Past Lessons and Future Prospects

R. Bloomfield, D. Craigen, F. Koob, M. Ullmann, more

Lecture Notes in Computer Science > Computer Safety, Reliability and Security > Formal Methods > 211-226

Based on a study by Adelard (UK) commissioned by the German Bundesamt fuer Sicherheit in der Informationstechnik this paper identifies crucial factors leading to the success or failure of the application of formal methods and provides ideas of improved technology adoption perspectives by analysing the formal methods market.

article

Property-oriented Production of Forged Magnesium Components

M. Graf, M. Ullmann, R. Kawalla

Materials Today: Proceedings > 2015 > 2 > Supplement 1 > S76-S84

The significance of light-weight construction in the automotive industry continues to increase. The reasons for this lie, for example, in the reduction of CO ₂ emissions achieved by fuel savings due to reductions in automobile weight. Low vehicle weights can be achieved through material substitution or improved topologies. Steel, however, remains the most commonly used material for the manufacture...

article

Effect of Grain refining Additives on Microstructure and Mechanical Properties of the Commercial Available Magnesium alloys AZ31 and AM50

K. Neh, M. Ullmann, R. Kawalla

Materials Today: Proceedings > 2015 > 2 > Supplement 1 > S219-S224

In order to fulfill the requirements of lightweight design, the establishment of magnesium wrought alloys is an important issue. To achieve this aim the development of new alloy compositions is essential. Therefore, the influence of different additives to commercial available magnesium alloys (AZ31, AM50) on microstructure and mechanical properties is investigated in this work. After casting of the...

article

Anisotropy of the Mechanical Properties of Twin-roll Cast, Rolled and Heat-treated AZ31 as a Function of Temperature and Strain rate

F. Berge, L. Krüger, M. Ullmann, C. Krbetschek, more

Materials Today: Proceedings > 2015 > 2 > Supplement 1 > S233-S241

The influence of temperature on the mechanical properties of twin-roll cast, rolled and heat-treated AZ31 was investigated under tensile loading from different directions (0°, 90). Therefore, quasi-static tensile tests with a strain rate of 0.76×10 ⁻³ s ⁻¹ , 0.73×10 ⁻² s ⁻¹ , and 0.72×10 ⁻¹ s ⁻¹ were performed with an electromechanical universal testing...

article

Twin Roll Casting and Strip Rolling of Several Magnesium Alloys

K. Neh, M. Ullmann, M. Oswald, F. Berge, more

Materials Today: Proceedings > 2015 > 2 > Supplement 1 > S45-S52

The twin roll casting (TRC) process enables the production of magnesium strips in an economic way. In combination with strip rolling, magnesium flat products with a great potential for industrial applications are produced. Current achievable mechanical properties of strips made of several magnesium alloys, produced by twin roll casting and subsequent strip rolling, are shown in this work. Therefore,...

article

Static Recrystallization Kinetics of a Twin-roll Cast AZ31 alloy

M. Ullmann, M. Graf, R. Kawalla

Materials Today: Proceedings > 2015 > 2 > Supplement 1 > S212-S218

The static recrystallization (SRX) behaviour of twin-roll cast and annealed magnesium AZ31 strip during hot deformation was determined under deformation conditions corresponding to the hot strip rolling process used in the production of twin-roll cast magnesium coils. Plane strain compression tests were performed using double-hit schedules at temperatures of 250°°C°–°400°°C, strain rates of 1°s ...

article

Low‐Dose Thyroxine Attenuates Autism‐Associated Adverse Effects of Fetal Alcohol in Male Offspring's Social Behavior and Hippocampal Gene Expression

Elif Tunc‐Ozcan, Timothy M. Ullmann, Pradeep K. Shukla, Eva E. Redei

Alcoholism: Clinical and Experimental Research > 37 > 11 > 1986 - 1995

BackgroundFetal alcohol spectrum disorder (FASD) is characterized by neurodevelopmental anomalies manifesting in cognitive and behavioral deficits in the offspring with diverse severities. Social behavior is affected in FASD, and these deficits overlap with those of autism spectrum disorder (ASD). Identifying some of the molecular characteristics related to ASD in an animal model of FASD could ultimately...

article

Improvement of ductility for Twin Roll Cast and rolled AZ31 strips by use of Taguchi method

M. Ullmann, H. Saleh, M. Schmitdchen, R. Kawalla, more

Archives of Civil and Mechanical Engineering > 2013 > 13 > 1 > 1-6

Magnesium alloys have great potential in the area of lightweight production especially in the automotive industry due to their favorable combination of mechanical properties and low density. The effects of various rolling parameters on ductility were investigated using the Taguchi method. The optimum combination of process parameters has been found through analysis of main effects of ductility and...

article

Improvement of ductility for Twin Roll Cast and rolled AZ31 strips by use of Taguchi method

M. Ullmann, H. Saleh, M. Schmitdchen, R. Kawalla, more

Archives of Civil and Mechanical Engineering > 2013 > Vol. 13, no. 1 > 1--6

article

Candidate Placental Biomarkers for Intrauterine Alcohol Exposure

Pradeep K. Shukla, Laura J. Sittig, Timothy M. Ullmann, Eva E. Redei

Alcoholism: Clinical and Experimental Research > 35 > 3 > 559 - 565

Background: Fetal alcohol spectrum disorder (FASD) is a leading cause of nongenetic mental retardation and other neurodevelopmental deficits. Earlier diagnosis of FASD would greatly improve prognosis for individuals and families affected by this disorder. Here, we identify candidate placental biomarkers in an animal model of FASD that recapitulates many aspects of human FASD. Methods: Pregnant Sprague‐Dawley...

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INFONA - science communication portal

Search results for: M. Ullmann

Risk factors for venous thromboembolism (VTE) after adrenalectomy for adrenal cortical neoplasms

AURIEL‐PsO: a randomized, double‐blind phase III equivalence trial to demonstrate the clinical similarity of the proposed biosimilar MSB11022 to reference adalimumab in patients with moderate‐to‐severe chronic plaque‐type psoriasis

CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules

Robotic Reoperative Anti-reflux Surgery: Low Perioperative Morbidity and High Symptom Resolution

Correction to: Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment

An empirical examination of the thickness profile formation of twin-roll-cast magnesium strips

Recommendations for the Development and Validation of Neutralizing Antibody Assays in Support of Biosimilar Assessment

Less is More: The Impact of Multidisciplinary Thyroid Conference on the Treatment of Well-Differentiated Thyroid Carcinoma

Numerical Investigation of the Oxide Scale Deformation Behaviour with Consideration of Carbon Content during Hot Forging

Scalable Application-Dependent Network on Chip Adaptivity for Dynamical Reconfigurable Real-Time Systems

Formal Methods Diffusion: Past Lessons and Future Prospects

Property-oriented Production of Forged Magnesium Components

Effect of Grain refining Additives on Microstructure and Mechanical Properties of the Commercial Available Magnesium alloys AZ31 and AM50

Anisotropy of the Mechanical Properties of Twin-roll Cast, Rolled and Heat-treated AZ31 as a Function of Temperature and Strain rate

Twin Roll Casting and Strip Rolling of Several Magnesium Alloys

Static Recrystallization Kinetics of a Twin-roll Cast AZ31 alloy

Low‐Dose Thyroxine Attenuates Autism‐Associated Adverse Effects of Fetal Alcohol in Male Offspring's Social Behavior and Hippocampal Gene Expression

Improvement of ductility for Twin Roll Cast and rolled AZ31 strips by use of Taguchi method

Improvement of ductility for Twin Roll Cast and rolled AZ31 strips by use of Taguchi method

Candidate Placental Biomarkers for Intrauterine Alcohol Exposure

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