Search results for: Thanh-Trang Vo

Items from 1 to 7 out of 7 results

chapter

BH3-Only Proteins and Their Effects on Cancer

Thanh-Trang Vo, Anthony Letai

Advances in Experimental Medicine and Biology > BCL-2 Protein Family > 49-63

Apoptosis, a form of cellular suicide is a key mechanism involved in the clearance of cells that are dysfunctional, superfluous or infected. For this reason, the cell needs mechanisms to sense death cues and relay death signals to the apoptotic machinery involved in cellular execution. In the intrinsic apoptotic pathway, a subclass of BCL-2 family proteins called the BH3-only proteins are responsible...

article

Targeting mTOR for the treatment of B cell malignancies

Jong‐Hoon Scott Lee, Thanh‐Trang Vo, David A. Fruman

British Journal of Clinical Pharmacology > 82 > 5 > 1213 - 1228

Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulator of cell growth, division and survival. Many haematologic malignancies exhibit elevated or aberrant mTOR activation, supporting the launch of numerous clinical trials aimed at evaluating the potential of single agent mTOR‐targeted therapies. While promising early clinical data using allosteric mTOR...

chapter

The Phosphatidylinositol 3‐Kinase Pathway in Human Malignancies

Samuel J. Klempner, Thanh‐Trang Vo, Andrea P. Myers, Lewis C. Cantley

Targeted Therapy in Translational Cancer Research > Targeted Therapy for Specific Molecular Aberrations > 315 - 324

Cancer accounts for one‐quarter of all deaths in the United States, and alterations in the phosphatidylinositol‐3‐kinase (PI3K) pathway components are some of the most frequent genomic alterations in human malignancies. The study of the PI3K pathway has translated into improved understanding of tumorigenesis and led to the identification of multiple therapeutic targets. Inhibition of the PI3K pathway...

article

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

Thanh-Trang Vo, Jeremy Ryan, Ruben Carrasco, Donna Neuberg, more

Cell > 2012 > 151 > 2 > 344-355

Despite decades of successful use of cytotoxic chemotherapy in acute myelogenous leukemia (AML), the biological basis for its differential success among individuals and for the existence of a therapeutic index has remained obscure. Rather than taking a genetic approach favored by many, we took a functional approach to ask how differential mitochondrial readiness for apoptosis (“priming”) might explain...

article

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

Ssang-Taek Lim, Xiao Lei Chen, Yangmi Lim, Dan A. Hanson, more

Molecular Cell > 2008 > 29 > 1 > 9-22

FAK is known as an integrin- and growth factor-associated tyrosine kinase promoting cell motility. Here we show that, during mouse development, FAK inactivation results in p53- and p21-dependent mesodermal cell growth arrest. Reconstitution of primary FAK ^−/− p21 ^−/− fibroblasts revealed that FAK, in a kinase-independent manner, facilitates p53 turnover via enhanced Mdm2-dependent...

article

Synthesis of the C1-phosphonate analog of UDP-GlcNAc

Robert Chang, Thanh-Trang Vo, Nathaniel S. Finney

Carbohydrate Research > 2006 > 341 > 12 > 1998-2004

We describe the first synthesis of the C1-phosphonate analog of UDP-GlcNAc, based on a new preparation of the corresponding glycosyl phosphonate. This C-glycosyl analog is shown to be a very weak inhibitor (K _i >10mM) of fungal chitin synthase, indicating that at least in this case the replacement of the anomeric oxygen with a methylene group is not an innocent substitution.

article

Hydrogen-bonding as a tool for building one-dimensional structures based on dimetal building blocks

Jitendra K. Bera, Thanh-Trang Vo, Richard A. Walton, Kim R. Dunbar

Polyhedron > 2003 > 22 > 22 > 3009-3014

The ligands isonicotinamide and nicotinamide are used to form assemblies of dimetal (M ₂ ) building units via a combination of coordinate bonds and intermolecular hydrogen-bond interactions. Polymeric networks of the linear, zig-zag and sinusoidal varieties are observed in the solid state depending on the ligands and metal precursors involved.

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Search results for: Thanh-Trang Vo

BH3-Only Proteins and Their Effects on Cancer

Targeting mTOR for the treatment of B cell malignancies

The Phosphatidylinositol 3‐Kinase Pathway in Human Malignancies

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

Synthesis of the C1-phosphonate analog of UDP-GlcNAc

Hydrogen-bonding as a tool for building one-dimensional structures based on dimetal building blocks

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