Search results for: Thilo Hackert

Items from 1 to 20 out of 142 results

article

Central pancreatectomy prevents postoperative diabetes

Rosa Klotz, Constanze Schilling, Charlotte Kuner, Ulf Hinz, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 30 > 7 > 951 - 961

Background Central pancreatectomy (CP) can be performed as an alternative surgical approach to distal pancreatectomy (DP) in the treatment of benign or low‐grade malignant lesions located in the neck and body of the pancreas, aiming to reduce loss of parenchyma and therefore organ failure. The objective of this study was to evaluate the short‐ and long‐term outcome of CP in comparison to DP. Methods...

article

Association between a polymorphic variant in the CDKN2B‐AS1/ANRIL gene and pancreatic cancer risk

Matteo Giaccherini, Riccardo Farinella, Manuel Gentiluomo, Beatrice Mohelnikova‐Duchonova, more

International Journal of Cancer > 153 > 2 > 373 - 379

Genes carrying high‐penetrance germline mutations may also be associated with cancer susceptibility through common low‐penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in our study. We conducted a multiphase study analysing 7745 single nucleotide polymorphisms (SNPs)...

article

Figures do matter: A literature review of 4587 robotic pancreatic resections and their implications on training

Giovanni B. Levi Sandri, Mohammed Abu Hilal, Safi Dokmak, Bjørn Edwin, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 30 > 1 > 21 - 35

Background The use of robotic assistance in minimally invasive pancreatic resection is quickly growing. Methods We present a systematic review of the literature regarding all types of robotic pancreatic resection (RPR). Our aim is to show for which procedures there is enough experience to permit safe training and provide an estimation of how many centers could serve as teaching institutions. ...

article

New criteria of resectability for pancreatic cancer: A position paper by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS)

Atsushi Oba, Marco Del Chiaro, Sohei Satoi, Sun‐Whe Kim, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 29 > 7 > 725 - 731

The symposium “New criteria of resectability for pancreatic cancer” was held during the 33nd meeting of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS) in 2021 to discuss the potential modifications that could be made in the current resectability classification. The meeting focused on setting the foundation for developing a new prognosis‐based resectability classification that is...

article

SmartPAN: In vitro and in vivo proof‐of‐safety assessments for an intra‐operative predictive indicator of postoperative pancreatic fistula

Thomas M. Pausch, Marc Bartel, Jiaqu Cui, Ophelia Aubert, more

Basic & Clinical Pharmacology & Toxicology > 130 > 4 > 542 - 552

Pancreatic surgery is complicated by untreated fluid leakage, but no tenable techniques exist to detect and close leakage sites during surgery. A novel hydrogel called SmartPAN has been developed to meet this need and is here assessed for safety before trials on human patients. First, resazurin assays were used to test the cytotoxic effects of SmartPAN's active bromothymol blue (BTB) indicator and...

article

Long‐term effect of everolimus in recurrent thymic neuroendocrine neoplasia

Matthias Lang, Thilo Hackert, Chrysanthi Anamaterou

Clinical Endocrinology > 95 > 5 > 744 - 751

Purpose Neuroendocrine neoplasia (NEN) of the thymus is a very rare entity with a poor prognosis. None of the treatments was proofed by studies. Usually, therapy protocols for bronchopulmonary carcinoids are used. So far no data exist on the effect of mammalian target of rapamycin (mTOR) inhibitors. We describe our long‐term experience with everolimus and give a thorough review of the therapeutic...

article

Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

Chiara Corradi, Manuel Gentiluomo, László Gajdán, Giulia Martina Cavestro, more

International Journal of Cancer > 148 > 11 > 2779 - 2788

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer‐related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability...

article

Genome‐wide association study identifies an early onset pancreatic cancer risk locus

Daniele Campa, Manuel Gentiluomo, Ofure Obazee, Alba Ballerini, more

International Journal of Cancer > 147 > 8 > 2065 - 2074

Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome‐wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset...

article

Claudin7‐dependent exosome‐promoted reprogramming of nonmetastasizing tumor cells

Daisuke Kyuno, Kun Zhao, Martina Schnölzer, Jan Provaznik, more

International Journal of Cancer > 145 > 8 > 2182 - 2200

Claudin7 (cld7) is a cancer‐initiating cell (CIC) marker in gastrointestinal tumors, a cld7‐knockdown (kd) being accompanied by loss of tumor progression. Tumor exosomes (TEX) restoring CIC activities, we explored the contribution of cld7. This became particularly interesting, as tight junction (TJ)‐ and glycolipid‐enriched membrane domain (GEM)‐derived cld7 is recruited into distinct TEX. TEXs were...

article

Abdominal drainage versus no drainage after distal pancreatectomy: study protocol for a randomized controlled trial

Joerg Kaiser, Willem Niesen, Pascal Probst, Thomas Bruckner, more

Trials > 2019 > 20 > 1 > 1-7

Background The placement of prophylactic intra-abdominal drains has been common practice in abdominal operations including pancreatic surgery. The PANDRA trial showed that the omission of drains following pancreatic head resection was non-inferior to intra-abdominal drainage in terms of postoperative reinterventions and superior in terms of clinically relevant pancreatic fistula rate and fistula-associated...

article

Surgical and local therapeutic concepts of oligometastatic pancreatic cancer in the era of effective chemotherapy

Willem Niesen, Florian Primavesi, Silvia Gasteiger, John Neoptolemos, more

European Surgery > 2019 > 51 > 3 > 153-164

Summary Background Pancreatic cancer (PC) remains a disease characterized by an extremely poor prognosis, which is often limited by advanced tumor stage at diagnosis. As surgery remains the only option for long-term survival, indications for resection to achieve a complete tumor removal have been extended in recent years, including locally advanced as well as metastatic disease. Methods Here, we...

article

Evolution of oncosurgical management of pancreatic cancer

Ulla Klaiber, Susanne Roth, Thilo Hackert, John P. Neoptolemos

European Surgery > 2019 > 51 > 3 > 165-173

Summary Background Pancreatic cancer is the third leading cause of cancer-related death in the Western world and is projected to soon become the second commonest cause of cancer mortality. During the past two decades, there have been important clinical developments in the fight against this aggressive disease. Objective The aim of this review article is to summarize the evolution of the multidisciplinary...

article

Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery

Felix C. F. Schmitt, Thorsten Brenner, Florian Uhle, Svenja Loesch, more

BMC Microbiology > 2019 > 19 > 1 > 1-13

Background Postoperative complications are of great relevance in daily clinical practice, and the gut microbiome might play an important role by preventing pathogens from crossing the intestinal barrier. The two aims of this prospective clinical pilot study were: (1) to examine changes in the gut microbiome following pancreatic surgery, and (2) to correlate these changes with the postoperative course...

article

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Felix Carl Fabian Schmitt, Vasil Manolov, Jakob Morgenstern, Thomas Fleming, more

Annals of Intensive Care > 2019 > 9 > 1 > 1-15

Background Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. Acute fibrinolysis shutdown has recently been described to be a crucial component of initial hypercoagulability in critically ill patients, although the underlying pathomechanisms,...

article

Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study

Daniele Campa, Martina Matarazzi, William Greenhalf, Maarten Bijlsma, more

International Journal of Cancer > 144 > 6 > 1275 - 1283

Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. For pancreatic ductal adenocarcinoma (PDAC) consensus is lacking whether risk is associated with long or short telomeres. Mendelian randomization approaches have shown that a score built from SNPs associated with LTL could be used as a robust risk marker...

article

Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming

Zhe Wang, Hanxue Sun, Jan Provaznik, Thilo Hackert, more

Journal of Experimental & Clinical Cancer Research > 2019 > 38 > 1 > 1-20

Background Cancer-initiating cell (CIC) exosomes (CIC-TEX) are suggested reprogramming Non-CIC. Mode of message transfer and engagement of CIC-markers being disputed, we elaborated the impact of CD44v6 and Tspan8 on the response of Non-CIC. Methods Non-metastasizing CD44v6- and Tspan8-knockdown (kd) pancreatic cancer cells served as Non-CIC. CIC-TEX coculture-induced changes were evaluated by deep-sequencing...

article

Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression

Kun Zhao, Zhe Wang, Thilo Hackert, Claudia Pitzer, more

Journal of Experimental & Clinical Cancer Research > 2018 > 37 > 1 > 1-23

Background The tetraspanins Tspan8 and CD151 promote metastasis, exosomes (Exo) being suggested to be important in the crosstalk between tumor and host. The contribution of Tspan8 and CD151 to host versus tumor-derived exosome (TEX) activities being not defined, we approached the questions using 3-methylcholanthrene-induced (MCA) tumors from wt, Tspan8ko, CD151ko and Tspan8/CD151 (db)ko mice, implanted...

article

Promising Long-Term Outcomes After Pelvic Exenteration

Yakup Kulu, Arianeb Mehrabi, Elias Khajeh, Johannes Klose, more

Annals of Surgical Oncology > 2019 > 26 > 5 > 1340-1349

Background Pelvic exenteration (PE) is a complex and challenging surgical procedure. The reported results of this procedure for primary and recurrent disease are limited and conflicting. Methods This study analyzed patient outcomes after all PEs performed in the authors’ department between October 2001 and December 2016. Relevant patient data were obtained from a prospective database. Morbidity...

article

Pancreatic surgery: we need clear definitions

André Mihaljevic, Mohammed Al-Saeedi, Thilo Hackert

Langenbeck's Archives of Surgery > 2019 > 404 > 2 > 159-165

Background Pancreatic surgery has undergone substantial changes during the last decades. Improved surgical techniques and perioperative care have contributed to improved outcomes and allow safe surgery with mortality rates below 5% in specialized centers today. In parallel, surgical indications and procedures have been continuously extended especially with regard to pancreatic cancer surgery including...

article

Neoadjuvant and adjuvant chemotherapy in pancreatic cancer

Ulla Klaiber, Carl-Stephan Leonhardt, Oliver Strobel, Christine Tjaden, more

Langenbeck's Archives of Surgery > 2018 > 403 > 8 > 917-932

Background Only 15–20% of patients with pancreatic ductal adenocarcinoma (PDAC) have a resectable tumor at the time of diagnosis. Effective multimodal treatment concepts including neoadjuvant chemotherapy are therefore needed. Following upfront resection, adjuvant chemotherapy has become mandatory to prevent early tumor recurrence. Purpose The aim of this article was to summarize existing evidence...

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INFONA - science communication portal

Search results for: Thilo Hackert

Central pancreatectomy prevents postoperative diabetes

Association between a polymorphic variant in the CDKN2B‐AS1/ANRIL gene and pancreatic cancer risk

Figures do matter: A literature review of 4587 robotic pancreatic resections and their implications on training

New criteria of resectability for pancreatic cancer: A position paper by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS)

SmartPAN: In vitro and in vivo proof‐of‐safety assessments for an intra‐operative predictive indicator of postoperative pancreatic fistula

Long‐term effect of everolimus in recurrent thymic neuroendocrine neoplasia

Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

Genome‐wide association study identifies an early onset pancreatic cancer risk locus

Claudin7‐dependent exosome‐promoted reprogramming of nonmetastasizing tumor cells

Abdominal drainage versus no drainage after distal pancreatectomy: study protocol for a randomized controlled trial

Surgical and local therapeutic concepts of oligometastatic pancreatic cancer in the era of effective chemotherapy

Evolution of oncosurgical management of pancreatic cancer

Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study

Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming

Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression

Promising Long-Term Outcomes After Pelvic Exenteration

Pancreatic surgery: we need clear definitions

Neoadjuvant and adjuvant chemotherapy in pancreatic cancer

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