The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
A radicicol analogue (analogue A) was found to inhibit interleukin 1 beta (IL-1β) and tumour necrosis factor alpha (tnf-α) secretion from THP-1 cells. If added to cells activated by interferon gamma and lipopolysaccharide, radicicol analogue A not only inhibited the secretion of IL-1β but also induced an extremely rapid degradation of IL-1β, IL-6 and TNF-α mRNA to undetectable levels within 5-8 h...
Due to its conformation, the hydrophilic compound [(D)MeSer-3, (4-OH)MeLeu-4] cyclosporin, 3, shows high affinity for cyclophilin A. This property, together with its lack of immunosuppression, confers 3 with very interesting anti HIV-1 activity.
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.