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Nest‐site selection exerts a fundamental maternal effect on offspring fitness in oviparous species. In many freshwater turtles, females do not care for their eggs after oviposition but rather rely on a nest's micro‐environment to incubate developing embryos although linkages between oviposition choices and overall fitness remain poorly evaluated. We tested predictions derived from multiple hypotheses...
Background and PurposeAMG 139 is a human anti‐IL‐23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to determine the pharmacology, preclinical characteristics and safety of this monoclonal antibody.
Experimental ApproachThe in vitro pharmacology, pharmacokinetics...
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